National trends in Azithromycin consumption during 2017–2023 in Kazakhstan: impact of the COVID-19 pandemic and the imperative for enhanced clinical guidelines
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: Feb. 21, 2025
Antibiotic
resistance
(AMR)
has
reached
critical
levels
globally,
especially
in
developing
economies
like
Kazakhstan,
largely
due
to
improper
antibiotic
use.
The
aim
of
this
study
was
examine
seven
years
azithromycin
sales
data
Kazakhstan
uncover
consumption
patterns
during
the
COVID-19
pandemic
and
develop
effective
strategies
combat
AMR.
This
analyzes
two
sets:
one
from
a
comprehensive
review
documents
regulating
use
Kazakhstan.
second
set
consists
pharmaco-epidemiological
analysis
procurement
provided
by
Vi-ORTIS.
Azithromycin
(ATC
group
J01FA10)
2017
2023
measured
DDD/1000
inhabitants/day
(DID)
using
ATC/DDD
methodology.
is
extensively
used
adult
pediatric
care
Its
consumption,
DDD
per
1,000
inhabitants,
surged
2020
with
outbreak.
steady
annual
increase
"Watch"
antibiotics,
including
azithromycin,
should
alarm
Kazakhstan's
healthcare
system.
trend
highlights
need
for
stronger
stewardship
programs,
targeted
interventions,
monitoring
prevent
overuse
misuse.
Addressing
crucial
maintaining
effectiveness
safeguarding
public
health.
Language: Английский
Cause-specific excess mortality in Denmark, Finland, Norway, and Sweden during the COVID-19 pandemic 2020–2022: a study using nationwide population data
European Journal of Epidemiology,
Journal Year:
2024,
Volume and Issue:
39(9), P. 1037 - 1050
Published: Sept. 1, 2024
Abstract
While
there
is
substantial
evidence
on
excess
mortality
in
the
first
two
years
of
COVID-19
pandemic,
no
study
has
conducted
a
cause-specific
analysis
for
whole
period
2020–2022
across
multiple
countries.
We
examined
during
Denmark,
Finland,
Norway,
and
Sweden—four
countries
with
similar
demographics
welfare
provisions,
which
implemented
different
pandemic
response
policies.
To
this
end,
we
utilized
nationwide
register-based
information
annual
deaths
stratified
by
age
sex,
applied
linear
regression
models
to
predict
based
reference
2010–2019.
Excess
were
obtained
contrasting
actual
expected
deaths.
Additional
analyses
employed
standardization
common
population,
as
well
population
adjustments
account
previous
Our
results
showed
that,
besides
due
(a
total
32,491
2020–2022),
all
experienced
cardiovascular
diseases
(in
11,610
deaths),
under-mortality
respiratory
other
than
9878)
dementia
8721).
The
was
particularly
pronounced
Finland
Norway
2022,
Sweden
2021–2022.
In
conclusion,
while
emerge
most
apparent
consequence
our
findings
suggest
that
also
been
influenced
substitutions
between
causes
death
over
time,
indirect
consequences
infection
responses—albeit
extents
Language: Английский
Relationship between COVID-19 cases and monthly mortality from all causes, cancer, cardiovascular diseases and diabetes in 16 countries, 2020–21
Margherita Pizzato,
No information about this author
Claudia Santucci,
No information about this author
Nazrul Islam
No information about this author
et al.
International Journal of Epidemiology,
Journal Year:
2024,
Volume and Issue:
54(1)
Published: Dec. 16, 2024
Abstract
Background
During
the
COVID-19
pandemic,
mortality
from
some
chronic
diseases
increased.
In
this
study,
we
evaluated
monthly
excess
all
causes,
cancer,
cardiovascular
(CVD)
and
diabetes
during
months
of
2020
2021,
examining
its
relationship
with
cases.
Methods
Monthly
cause-specific
data
were
downloaded
public
repositories
national
statistics
offices
or
directly
requested
them,
population
obtained
United
Nations
archives.
Excess
deaths
estimated
as
difference
between
observed
expected
deaths.
for
2021
calculated
using
a
quasi-Poisson
regression
model
trained
on
2010–19
(or
shorter
timespan
if
full
decade
was
not
available).
To
quantify
correlation
cases
mortality,
used
Spearman’s
coefficient
(rs).
Results
The
study
included
16
countries
that
provided
causes
death
(Argentina,
Austria,
Brazil,
Switzerland,
Chile,
Czech
Republic,
Germany,
Georgia,
Hungary,
Italy,
Lithuania,
Latvia,
Mexico,
Serbia,
Slovakia
USA).
A
positive
found
in
(rs
ranging
0.61
to
0.91),
CVD
11
0.45
0.85)
13
0.42
0.79).
above
5%
14
both
seven
nine
12
2021.
No
cancer
any
considered.
Conclusions
persisted
several
throughout
These
increases
coincide
peaks,
supporting
short-term
impact
pandemic
these
causes.
Language: Английский