The Contentious Origins of SARS-CoV-2: A Comprehensive Review of Current Knowledge DOI Creative Commons
José L. Domingo

Published: Feb. 19, 2025

The emergence of SARS-CoV-2 in late 2019 triggered a global pandemic (COVID-19) that has claimed millions lives and continues to impact public health systems worldwide. This review examines current scientific evidence regarding the virus's origins, focusing on two primary hypotheses: zoonotic spillover laboratory-related emergence. A comprehensive analysis peer-reviewed literature primarily published between December 2023 January 2025 was conducted, identifying relevant studies through searches PubMed Scopus databases. Key earlier publications are also included provide essential background context. revealed strong phylogenetic supporting natural origin, with several indicating close genetic relationships bat coronaviruses. Environmental sampling data from Huanan Seafood Market detected RNA high number environmental samples animal stalls. While preponderance supports spillover, absence definitively identified intermediate host maintains some uncertainty. concludes evidence-based recommendations for enhanced viral surveillance, implementation One Health approaches, strengthened international collaboration frameworks prevent future coronavirus pandemics.

Language: Английский

Elegant and Innovative Recoding Strategies for Advancing Vaccine Development DOI Creative Commons
François Meurens, Fanny Renois, Uladzimir Karniychuk

et al.

Vaccines, Journal Year: 2025, Volume and Issue: 13(1), P. 78 - 78

Published: Jan. 16, 2025

Recoding strategies have emerged as a promising approach for developing safer and more effective vaccines by altering the genetic structure of microorganisms, such viruses, without changing their proteins. This method enhances vaccine safety efficacy while minimizing risk reversion to virulence. frequency CpG dinucleotides, which in turn activates immune responses ensures strong attenuation pathogens. Recent advancements highlight synonymous recoding's potential, offering improved stability immunogenicity compared traditional methods. Live attenuated using classical methods pose virulence can be time-consuming produce. Synonymous recoding, involving numerous codon alterations, boosts stability. One challenge is balancing with yield; however, innovations like Zinc-finger antiviral protein (ZAP) knockout cell lines enhance production. Beyond viral vaccines, recoding apply bacterial exemplified modified Escherichia coli Streptococcus pneumoniae strains, show reduced Despite results, challenges ensuring stability, high yield, regulatory approval remain. Briefly, ongoing research aims harness these comprehensive improvements design deployment. In this commentary, we sought further engage community's interest elegant briefly highlighting its main advantages, disadvantages, future prospects.

Language: Английский

Citations

0
Differences between Influenza H5N1, A/H1N1 2009, and SARS-CoV-2 in a pandemic risk scenario DOI Creative Commons
Pablo I. Plaza, Sergio A. Lambertucci

Travel Medicine and Infectious Disease, Journal Year: 2025, Volume and Issue: 64, P. 102811 - 102811

Published: Feb. 1, 2025

Language: Английский

Citations

0
The Contentious Origins of SARS-CoV-2: A Comprehensive Review of Current Knowledge DOI Creative Commons
José L. Domingo

Published: Feb. 11, 2025

The emergence of SARS-CoV-2 in late 2019 triggered a global pandemic (COVID-19) that has claimed millions lives and continues to impact public health systems worldwide. This review examines current scientific evidence regarding the virus's origins, focusing on two primary hypotheses: zoonotic spillover laboratory-related emergence. A comprehensive analysis peer-reviewed literature published between December 2023 January 2025 was conducted, identifying relevant studies through searches PubMed Scopus databases. revealed strong phylogenetic supporting natural origin, with several indicating close genetic relationships bat coronaviruses. Environmental sampling data from Huanan Seafood Market detected RNA high number environmental samples animal stalls. While preponderance supports spillover, absence definitively identified intermediate host maintains some uncertainty. concludes evidence-based recommendations for enhanced viral surveillance, implementation One Health approaches, strengthened international collaboration frameworks prevent future coronavirus pandemics.

Language: Английский

Citations

0
The Contentious Origins of SARS-CoV-2: A Comprehensive Review of Current Knowledge DOI Creative Commons
José L. Domingo

Published: Feb. 17, 2025

The emergence of SARS-CoV-2 in late 2019 triggered a global pandemic (COVID-19) that has claimed millions lives and continues to impact public health systems worldwide. This review examines current scientific evidence regarding the virus's origins, focusing on two primary hypotheses: zoonotic spillover laboratory-related emergence. A comprehensive analysis peer-reviewed literature primarily published between December 2023 January 2025 was conducted, identifying relevant studies through searches PubMed Scopus databases. Key earlier publications are also included provide essential background context. revealed strong phylogenetic supporting natural origin, with several indicating close genetic relationships bat coronaviruses. Environmental sampling data from Huanan Seafood Market detected RNA high number environmental samples animal stalls. While preponderance supports spillover, absence definitively identified intermediate host maintains some uncertainty. concludes evidence-based recommendations for enhanced viral surveillance, implementation One Health approaches, strengthened international collaboration frameworks prevent future coronavirus pandemics.

Language: Английский

Citations

0
The Contentious Origins of SARS-CoV-2: A Comprehensive Review of Current Knowledge DOI Creative Commons
José L. Domingo

Published: Feb. 19, 2025

The emergence of SARS-CoV-2 in late 2019 triggered a global pandemic (COVID-19) that has claimed millions lives and continues to impact public health systems worldwide. This review examines current scientific evidence regarding the virus's origins, focusing on two primary hypotheses: zoonotic spillover laboratory-related emergence. A comprehensive analysis peer-reviewed literature primarily published between December 2023 January 2025 was conducted, identifying relevant studies through searches PubMed Scopus databases. Key earlier publications are also included provide essential background context. revealed strong phylogenetic supporting natural origin, with several indicating close genetic relationships bat coronaviruses. Environmental sampling data from Huanan Seafood Market detected RNA high number environmental samples animal stalls. While preponderance supports spillover, absence definitively identified intermediate host maintains some uncertainty. concludes evidence-based recommendations for enhanced viral surveillance, implementation One Health approaches, strengthened international collaboration frameworks prevent future coronavirus pandemics.

Language: Английский

Citations

0