PPAR-γ in Melanoma and Immune Cells: Insights into Disease Pathogenesis and Therapeutic Implications DOI Creative Commons
В. В. Соболев,

Ekaterina Tchepourina,

А. Г. Соболева

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(7), P. 534 - 534

Published: April 2, 2025

Changes in skin pigmentation, like hyperpigmentation or moles, can affect appearance and social life. Unlike locally containable malignant melanomas are aggressive spread rapidly, disproportionately affecting younger individuals with a high potential for metastasis. Research has shown that the peroxisome proliferator-activated receptor gamma (PPAR-γ) its ligands exhibit protective effects against melanoma. As transcription factor, PPAR-γ is crucial functions fatty acid storage glucose metabolism. Activation of promotes lipid uptake enhances sensitivity to insulin. In many cases, it also inhibits growth cancer cell lines, breast, gastric, lung, prostate cancer. melanoma, regulates proliferation, differentiation, apoptosis, survival. During tumorigenesis, controls metabolic changes immunogenicity stromal cells. agonists target hypoxia-induced angiogenesis tumor therapy, but their on tumors be suppressive promotional, depending environment. Published data show PPAR-γ-targeting agents effective specific groups patients, further studies needed understand lesser-known biological address existing safety concerns. This review provides summary current understanding involvement

Language: Английский

PPAR-γ in Melanoma and Immune Cells: Insights into Disease Pathogenesis and Therapeutic Implications DOI Creative Commons
В. В. Соболев,

Ekaterina Tchepourina,

А. Г. Соболева

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(7), P. 534 - 534

Published: April 2, 2025

Changes in skin pigmentation, like hyperpigmentation or moles, can affect appearance and social life. Unlike locally containable malignant melanomas are aggressive spread rapidly, disproportionately affecting younger individuals with a high potential for metastasis. Research has shown that the peroxisome proliferator-activated receptor gamma (PPAR-γ) its ligands exhibit protective effects against melanoma. As transcription factor, PPAR-γ is crucial functions fatty acid storage glucose metabolism. Activation of promotes lipid uptake enhances sensitivity to insulin. In many cases, it also inhibits growth cancer cell lines, breast, gastric, lung, prostate cancer. melanoma, regulates proliferation, differentiation, apoptosis, survival. During tumorigenesis, controls metabolic changes immunogenicity stromal cells. agonists target hypoxia-induced angiogenesis tumor therapy, but their on tumors be suppressive promotional, depending environment. Published data show PPAR-γ-targeting agents effective specific groups patients, further studies needed understand lesser-known biological address existing safety concerns. This review provides summary current understanding involvement

Language: Английский

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