Synthesis and characterization of innovative GA@Ag-CuO nanocomposite with potent antimicrobial and anticancer properties DOI Creative Commons
Amr H. Hashem, Mostafa A. Abdel-Maksoud, Sabiha Fatima

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 3, 2025

Cancer and microbial infections place a significant burden on the world's health systems can increase rate of disease mortality. In current study, novel nanocomposite based Gum Arabic, silver copper oxide nanoparticles (GA@Ag-CuO nanocomposite) was synthesized to overcome problem infection in cancer treatment. Characterization using UV-Vis. spectrophotometer reveals that, observed peak spectrum formed by O.D. at 0.755, confirmed that produced GA@Ag-CuO small discernible 360 nm. The particles' diameters varied from 9.5 nm 49.5 nm, with mean diameter 25.53 ± 1.4 created Arabic filtrate rich active functional groups, provided polydisperse NPs were intended reduce, stabilize, act as capping agents. Based XRD data, crystallized had face-centered (fcc) crystal structure. Biosafety assessed toward Wi 38 normal cell line, where it showed safety tested line IC50 154.2 µg/mL. Antimicrobial results has antibacterial activity MICs 15.6, 125, 31.25 125 µg/mL against S. epidermis, aureus, L. plantrum, typhimurium, respectively. Likewise, antifungal C. albicans neoformans 62.5 15.62 µg/ml, Moreover, displayed promising anticancer 26.11 59.5 µg/ml MCF-7 Hep-G2, conclusion, demonstrated antibacterial, antifungal, activities.

Language: Английский

Synthesis and characterization of innovative GA@Ag-CuO nanocomposite with potent antimicrobial and anticancer properties DOI Creative Commons
Amr H. Hashem, Mostafa A. Abdel-Maksoud, Sabiha Fatima

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 3, 2025

Cancer and microbial infections place a significant burden on the world's health systems can increase rate of disease mortality. In current study, novel nanocomposite based Gum Arabic, silver copper oxide nanoparticles (GA@Ag-CuO nanocomposite) was synthesized to overcome problem infection in cancer treatment. Characterization using UV-Vis. spectrophotometer reveals that, observed peak spectrum formed by O.D. at 0.755, confirmed that produced GA@Ag-CuO small discernible 360 nm. The particles' diameters varied from 9.5 nm 49.5 nm, with mean diameter 25.53 ± 1.4 created Arabic filtrate rich active functional groups, provided polydisperse NPs were intended reduce, stabilize, act as capping agents. Based XRD data, crystallized had face-centered (fcc) crystal structure. Biosafety assessed toward Wi 38 normal cell line, where it showed safety tested line IC50 154.2 µg/mL. Antimicrobial results has antibacterial activity MICs 15.6, 125, 31.25 125 µg/mL against S. epidermis, aureus, L. plantrum, typhimurium, respectively. Likewise, antifungal C. albicans neoformans 62.5 15.62 µg/ml, Moreover, displayed promising anticancer 26.11 59.5 µg/ml MCF-7 Hep-G2, conclusion, demonstrated antibacterial, antifungal, activities.

Language: Английский

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