The Circadian Clock and Human Health

Current Biology, Journal Year: 2016, Volume and Issue: 26(10), P. R432 - R443

Published: May 1, 2016

Language: Английский

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Sleep, circadian rhythms, and the pathogenesis of Alzheimer Disease

Experimental & Molecular Medicine, Journal Year: 2015, Volume and Issue: 47(3), P. e148 - e148

Published: March 13, 2015

Disturbances in the sleep–wake cycle and circadian rhythms are common symptoms of Alzheimer Disease (AD), they have generally been considered as late consequences neurodegenerative processes. Recent evidence demonstrates that disruption often occur early course disease may even precede development cognitive symptoms. Furthermore, appears to regulate levels pathogenic amyloid-beta peptide brain, manipulating sleep can influence AD-related pathology mouse models via multiple mechanisms. Finally, clock system, which controls other diurnal oscillations mice humans, also a role process. In this review, we examine current literature related mechanisms by might impact AD pathogenesis, discuss potential therapeutic strategies targeting these systems for prevention AD. The onset progression Alzheimer's be associated with disturbance before appear. is condition primarily affects older people, leading dementia. Disturbed patterns problems rhythms, physiological processes follow natural 24-hour cycle, disease. David Holtzman co-workers at Washington University School Medicine, USA, reviewed research suggesting actually stages exacerbate team highlighted linking cycles regulation certain Alzheimer-related peptides brains, together studies connecting rhythms. Therapies could therefore help fight against future.

Language: Английский

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Animal models of major depression and their clinical implications

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2015, Volume and Issue: 64, P. 293 - 310

Published: April 18, 2015

Language: Английский

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Circadian disruption: What do we actually mean?

European Journal of Neuroscience, Journal Year: 2018, Volume and Issue: 51(1), P. 531 - 550

Published: Nov. 7, 2018

The circadian system regulates physiology and behavior. Acute challenges to the system, such as those experienced when traveling across time zones, will eventually result in re-synchronization local environmental cues, but this is oftentimes accompanied by adverse short-term consequences. When are chronically, adaptation may not be achieved, for example case of rotating night shift workers. transient chronic disturbance most frequently referred "circadian disruption", many other terms have been proposed used refer similar situations. It now beyond doubt that contributes health disease, emphasizing need clear terminology describing their goal review provide an overview describe disruption discuss quantifications experimental observational settings with a focus on human research, highlight limitations currently available tools. For research advance translational science, clear, operationalizable, scalable key, they enable improved assessment reproducibility results, ideally ranging from mechanistic settings, including animal large-scale randomized clinical trials.

Language: Английский

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The impact of sleep disorders on glucose metabolism: endocrine and molecular mechanisms

Diabetology & Metabolic Syndrome, Journal Year: 2015, Volume and Issue: 7(1)

Published: March 23, 2015

Modern lifestyle has profoundly modified human sleep habits. Sleep duration shortened over recent decades from 8 to 6.5 hours resulting in chronic deprivation. Additionally, irregular sleep, shift work and travelling across time zones lead disruption of circadian rhythms asynchrony between the master hypothalamic clock pacemakers peripheral tissues. Furthermore, obstructive apnea syndrome (OSA), which affects 4 - 15% population, is not only characterized by impaired architecture but also repetitive hemoglobin desaturations during sleep. Epidemiological studies have identified as an independent risk factor for all cause of-, well cardiovascular, mortality/morbidity. More recently, abnormalities were causally linked impairments glucose homeostasis, metabolic Type 2 Diabetes Mellitus (T2DM). This review summarized current knowledge on alterations associated with most prevalent disturbances, i.e. short duration, OSA. We focused various endocrine molecular mechanisms underlying associations inadequate quality, quantity timing tolerance, insulin resistance pancreatic β-cell dysfunction. Of these mechanisms, role hypothalamic-pituitary-adrenal axis, tissues, adipose tissue metabolism, sympathetic nervous system activation, oxidative stress whole-body inflammation are discussed. impact intermittent hypoxia fragmentation (key components OSA) intracellular signaling metabolism muscle, liver, fat pancreas examined. In summary, this provides explanations common disturbances pathogenesis T2DM.

Language: Английский

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Dosing-Time Makes the Poison: Circadian Regulation and Pharmacotherapy

Trends in Molecular Medicine, Journal Year: 2016, Volume and Issue: 22(5), P. 430 - 445

Published: April 5, 2016

Language: Английский

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Microglia inflammatory responses are controlled by an intrinsic circadian clock

Brain Behavior and Immunity, Journal Year: 2014, Volume and Issue: 45, P. 171 - 179

Published: Nov. 26, 2014

Language: Английский

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Circadian Dysfunction Induces Leptin Resistance in Mice

Cell Metabolism, Journal Year: 2015, Volume and Issue: 22(3), P. 448 - 459

Published: July 10, 2015

Language: Английский

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Light as a circadian stimulus for architectural lighting

Lighting Research & Technology, Journal Year: 2016, Volume and Issue: 50(4), P. 497 - 510

Published: Dec. 6, 2016

Consideration is being given to the adoption of a new metric characterizing light as it affects human circadian system. Much has been learned over past couple decades about stimulus for system regulation, so appropriate that these discussions take place. The present paper develops an argument adopting quantifying in architectural spaces. (a) was developed from several lines biophysical research, including those basic retinal neurophysiology; (b) validated controlled experiments; and (c) used successfully number real-world applications. Any metrics should each foundational points into consideration.

Language: Английский

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A Review of Human Physiological Responses to Light: Implications for the Development of Integrative Lighting Solutions

LEUKOS The Journal of the Illuminating Engineering Society of North America, Journal Year: 2021, Volume and Issue: 18(3), P. 387 - 414

Published: March 26, 2021

Architectural lighting has potent biological effects but applied practices that capitalize on this potential have been limited. In review, we endeavor to consolidate and synthesize key references will be useful for professionals, with the goal of supporting knowledge translation into pragmatic strategies. Specifically, explain relevant terminology, outline basic concepts, identify references, provide a balanced overview current state knowledge, highlight important remaining questions. We summarize physiological light human health well-being, including description processes underlying photic regulation circadian, neuroendocrine, neurobehavioral functions. review seminal work elucidating elements mediating potency these responses, specific attention factors critical interpreting those findings. parallel, endorse melanopic Equivalent Daylight Illuminance (Ev,melD65) as preferred measure quantify light. Ultimately, while future studies are necessary further facilitate laboratory domestic workplace settings, immediate better support is clear. Aiming integrative solutions biologically high during day low night perhaps most improvement made in order applications humans.

Language: Английский

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