Mental health law in Philippines: health policy issues governing mental health promotion among Filipino older adults with serious mental illnesses
Muamar O. Aldalaeen,
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Rabia H. Haddad,
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Talal Bani Ahmad
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et al.
Mental Health and Social Inclusion,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 22, 2025
Purpose
This
study
aims
to
discuss
the
mental
health
in
Philippines
and
existing
laws
policies
governing
care
among
Filipino
older
adults
with
serious
illnesses.
Design/methodology/approach
The
used
policy
research
understand
issues
gaps
Philippine
health-care
system
adults.
deductive
methods
(based
on
testing
specific
hypotheses)
inductive
of
inquiry
formation
general
inferences),
which
are
necessary
but
insufficient
for
theory
development
without
retroductive
reasoning.
researcher
believes
that
critical
realism
provides
a
philosophically
grounded
theoretical
framework
can
be
underpin
into
causal
mechanisms
such
as
analysis.
Findings
Mental
is
integral
holistic
health.
commitment
improve
services
highlighted
recent
legislative
actions
policymakers.
professionals
experts
suggest
failure
address
psycho-social
problems
population
will
hinder
attempts
increase
social
capital,
promote
human
reduce
poverty.
Originality/value
A
disregard
still
apparent.
norm
continues
include
chronic
shortage
professionals,
an
inadequate
number
facilities
hospitals,
lack
accessible
equitable
treatment,
especially
marginalized
sectors,
stigma,
discrimination
exclusion
against
people
conditions
very
widespread.
Some
refuse
even
get
help
treatment
their
disorders
not
because
high
cost
stigma
attached
disorders.
Language: Английский
Impact of GSK-3β and CK-1δ on Wnt signaling pathway in alzheimer disease: A dual target approach
Bioorganic Chemistry,
Journal Year:
2024,
Volume and Issue:
147, P. 107378 - 107378
Published: April 17, 2024
Language: Английский
Computational Analysis of Stilbenes as Potential Multi-Targeted Therapeutics for Alzheimer’s Disease
Osmaniye Korkut Ata Üniversitesi Fen Bilimleri Enstitüsü Dergisi,
Journal Year:
2025,
Volume and Issue:
8(1), P. 145 - 166
Published: Jan. 15, 2025
Purpose:
The
aim
of
this
study
is
to
compare
13
stilbenes
and
5
FDA-approved
drugs
used
in
the
treatment
Alzheimer’s
disease
(AD)
by
ADME
prediction
molecular
docking
method.
Cholinergic,
amyloid,
tau,
oxidative
stress
inflammation
hypotheses
involved
AD
pathology
were
targeted
docking.
Materials
Methods:
SwissADME
has
been
determine
physicochemical,
lipophilicity,
water
solubility,
pharmacokinetics,
drug-likeness
medicinal
chemistry
properties
(resveratrol,
pterostilbene,
oxyresveratrol,
piceatannol,
pinosylvin,
isorhapontigenin,
isorhapontin,
astringin,
piceid
(polydatin),
mulberroside
A)
(tacrine,
donepezil,
rivastigmine,
galantamine,
memantine).
CBDOCK2
binding
affinity
target
proteins
(AChE,
BuChE,
APP,
BACE,
GSK-3β,
CDK5,
SOD,
CAT,
GPx,
Cox-2,
iNOS,
IL-1β,
TNF-α).
Results:
SWISS
results
showed
that
could
be
as
natural
products
AD.
indicated
A
best
vina
score
(kcal/mol)
followed
galanthamine,
resveratrol,
tacrine,
memantine.
Conclusion:
Our
evaluated
for
using
computational
approaches.
highlight
its
potential
therapeutic
effects
on
various
pathology.
More
research
needed
validate
these
findings
clinical
practice.
Language: Английский
Gene Co-Expression Analysis Reveals Functional Differences Between Early- and Late-Onset Alzheimer’s Disease
Current Issues in Molecular Biology,
Journal Year:
2025,
Volume and Issue:
47(3), P. 200 - 200
Published: March 18, 2025
The
rising
prevalence
of
Alzheimer’s
disease
(AD),
particularly
among
older
adults,
has
driven
increased
research
into
its
underlying
mechanisms
and
risk
factors.
Aging,
genetic
susceptibility,
cardiovascular
health
are
recognized
contributors
to
AD,
but
how
the
age
onset
affects
progression
remains
underexplored.
This
study
investigates
role
early-
versus
late-onset
(EOAD
LOAD,
respectively)
in
shaping
trajectory
cognitive
decline.
Leveraging
data
from
Religious
Orders
Study
Memory
Aging
Project
(ROSMAP),
two
cohorts
were
established:
individuals
with
early-onset
AD
those
AD.
Comprehensive
analyses,
including
differential
gene
expression
profiling,
pathway
enrichment,
co-expression
network
construction,
conducted
identify
distinct
molecular
signatures
associated
each
cohort.
Network
modularity
learning
algorithms
used
discern
inner
structure
networks
their
related
functional
features.
Computed
descriptors
provided
deeper
insights
influence
at
on
biological
Language: Английский
Introduction to Alzheimer's Disease, Biomarkers, and the AI Revolution
Advances in medical technologies and clinical practice book series,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 23
Published: June 28, 2024
Alzheimer's
disease
(AD)
is
a
progressive
neurodegenerative
that
results
in
steady
decline
cognitive
ability
and
memory
function.
As
society
ages,
the
need
for
an
optimum
AD
management
strategy
becomes
more
important.
This
chapter
analyzes
stage-construction
etiology
escalating
symptoms
of
discovered
throughout
this
review,
as
well
identification
barrier
to
precise
diagnosis.
The
artificial
intelligence
achieve
quicker
detection
through
machine
learning,
data
analytics,
predictive
modeling
also
being
considered.
Therefore,
employing
AI
AD-related
studies
novel
approach
enhancing
patient
outcomes.
Proper
diagnosis
parallel
increased
probability
many
parameters
one
most
difficult
moments
identify.
However,
use
evaluation
sensor
network
technologies
big
analysis
has
advanced,
preventive
instruments
can
be
used.
Thus,
technology
gives
humanity
hope
stop
or,
at
very
least,
slow
down
tragedy.
Language: Английский
Emerging Role of Medicinal Herbs on Alzheimer’s Disease and Memory Deficits
IntechOpen eBooks,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 30, 2024
Alzheimer’s
disease
(AD)
is
an
age-related
neurodegenerative
disorder
characterized
by
memory
deficits.
It
associated
with
the
presence
of
intracellular
neurofibrillary
tangles
(NFTs)
and
extracellular
amyloid
beta
plaques,
loss
neuronal
subpopulations,
cholinergic
fibers,
microglial
inactivation.
According
to
studies,
from
year
2000–2020,
death
toll
attributed
AD
increased
146.2%,
its
major
causes
are
neurodegeneration
oxidative
stress
(OS).
Currently,
available
treatment
options
limited,
there
no
cure
for
disease.
In
Asia,
such
as
in
China
India,
herbal
medicines
have
been
used
diseases
thousands
years,
which
has
recently
attracted
considerable
attention
due
development
curative
drugs
AD.
this
chapter,
we
first
summarized
pathogenic
factors
secondly,
that
extensively
investigated
both
models
clinical
trials.
Also,
specified
potential
targets
herbs
view
signaling
pathways
implicated
inflammatory
pathogenesis.
We
consider
knowledge
can
be
favorable
disease-modifying
Language: Английский
New Insights into the Development of Donepezil-Based Hybrid and Natural Molecules as Multi-Target Drug Agents for Alzheimer’s Disease Treatment
Molecules,
Journal Year:
2024,
Volume and Issue:
29(22), P. 5314 - 5314
Published: Nov. 11, 2024
Alzheimer's
disease
(AD)
involves
a
complex
pathophysiology
with
multiple
interconnected
subpathologies,
including
protein
aggregation,
impaired
neurotransmission,
oxidative
stress,
and
microglia-mediated
neuroinflammation.
Current
treatments,
which
generally
target
single
subpathology,
have
failed
to
modify
the
disease's
progression,
providing
only
temporary
symptom
relief.
Multi-target
drugs
(MTDs)
address
several
aggregation
of
pathological
proteins.
In
this
review,
we
cover
hybrid
molecules
published
between
2014
2024.
We
offer
an
overview
strategies
employed
in
drug
design
approaches
that
led
notable
improvements
reduced
hepatotoxicity.
Our
aim
is
insights
into
potential
development
new
drugs.
This
highlights
multi-target
featuring
heterocycles
Language: Английский