The role of cut-off values for creatinine, blood urea nitrogen, and uric acid in prognostic assessment of chronic heart failure: a retrospective cohort study

BMC Cardiovascular Disorders, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 22, 2025

Abstract Background Chronic heart failure (CHF) significantly harms patients and society, causing high mortality reduced quality of life, straining healthcare systems; early identification intervention are crucial for improving long-term prognosis. Methods This retrospective cohort study involved 297 CHF patients. After collecting data on demographics, lab results, echocardiography, comorbidities, ROC analysis was used to determine optimal cut-off values, followed by survival multivariate Cox regression identify poor prognosis risk factors. Results set cut-offs Scr, BUN, UA at 101.5 µmol/L, 8.61 mmol/L, 462 with AUCs 0.602 (Scr, UA) 0.674 (BUN). Kaplan-Meier showed significant curve separation, while identified factors prognosis: Scr ≥ µmol/L (HR = 2.209, 95% CI 1.372–3.557, P 0.001), BUN mmol/L 3.709, 2.270–6.061, < 2.625, 1.631–4.228, male sex(HR 1.764, 1.067–2.915, 0.027), hyperlipidemia 0.567, 0.351–0.916, 0.02), re-hospitalization(HR 0.480, 0.280–0.826, 0.008). Subgroup indicates that gender is a factor females (OR:2.424, 0.001); age also posed (OR:1.026, 0.036). NYHA class IV had an OR 0.42 compared III ( 0.307 II 0.016). Patients without CHD 1.905-fold increased 0.033). Conclusion highlights key characteristics, assessment parameters, patients, emphasizing the importance levels in management guiding future research.

Language: Английский

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Protective activity of adipose-derived stem cell extracellular vesicles in ischemia and/or reperfusion

World Journal of Stem Cells, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 17, 2025

Increasing evidence of the significant clinical value protection against ischemia/reperfusion injury has contributed to realization independent importance this approach in improving prognosis and reducing cardiovascular mortality. Extracellular vesicles (EVs) derived by adipose mesenchymal stem cells may mediate paracrine effects provide regenerative anti-inflammatory properties, which are enhanced γ-aminobutyric acid. The protective on cardiac myocytes result from EV embarked miR-21-5p, is a target for thioredoxin-interacting protein, regulating formation protein-thioredoxin complexes subsequently enhancing antioxidant activity thioredoxin. It been found that acid governs myocardial bioenergetics through suppressing inflammation supporting mitochondrial structure. Finally, cell-based cell-free therapy based adipose-derived cell EVs considered promising individualized management ischemia-induced cardiomyopathy.

Language: Английский

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Diseased Tendon Models Demonstrate Influence of Extracellular Matrix Alterations on Extracellular Vesicle Profile

Bioengineering, Journal Year: 2024, Volume and Issue: 11(10), P. 1019 - 1019

Published: Oct. 12, 2024

Tendons enable movement through their highly aligned extracellular matrix (ECM), predominantly composed of collagen I. Tendinopathies disrupt the structural integrity tendons by causing fragmentation fibers, disorganization fiber bundles, and an increase in glycosaminoglycans microvasculature, thereby driving apparent biomechanical regenerative capacity patients. Moreover, complex cellular communication within tendon microenvironment ultimately dictates fate between healthy diseased tendon, wherein vesicles (EVs) may facilitate tendon's transporting biomolecules tissue. In this study, we aimed to elucidate how EV functionality is altered context microenvironments using polycaprolactone (PCL) electrospun scaffolds mimicking pathological matrices. Scaffolds were characterized for alignment, mechanical properties, activity. EVs isolated analyzed concentration, heterogeneity, protein content. Our results show that our mimicked led secretion baseline metabolic activity over where reduced a significant 5 days observed. These findings suggest scaffold mechanics influence functionality, offering insights into homeostasis. Future research should further investigate cargo affects microenvironment.

Language: Английский

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Promising nanotherapeutics of stem cell extracellular vesicles in liver regeneration

Regenerative Therapy, Journal Year: 2024, Volume and Issue: 26, P. 1037 - 1047

Published: June 1, 2024

Language: Английский

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