Laboratory Animal Research, Journal Year: 2025, Volume and Issue: 41(1)

Published: Feb. 3, 2025

Abstract Zebrafish ( Danio rerio ) have emerged as an influential model for studying human epithelial pathology, particularly because of their genetic similarity to humans and unique physiological traits. This review explores the structural functional homology between zebrafish tissues in organs, such gastrointestinal system, liver, kidneys. possess significant cellular with mammals, which facilitates investigation various diseases, including inflammatory bowel disease, nonalcoholic fatty liver polycystic kidney disease. The advantages using a organism include rapid external development, ease manipulation, advanced imaging capabilities, allowing real-time observation disease processes. However, limitations exist, concerning lack organs potential incomplete phenocopy conditions. Despite these challenges, ongoing research adult promises enhance our understanding mechanisms regenerative By revealing similarities differences cell function pathways, this highlights value translational advancing knowledge health developing targeted therapies.

Language: Английский