Molecular Medicine Reports, Journal Year: 2025, Volume and Issue: 31(4), P. 1 - 34
Published: Feb. 24, 2025
Flavonoids are a group of polyphenolic compounds distributed in vegetables, fruits and other plants, which have considerable antioxidant, anti‑tumor anti‑inflammatory activities. Several types gastrointestinal (GI) cancer the most common malignant tumors world. A large number studies shown that flavonoids inhibitory effects on cancer, they recognized as class potential drugs. Therefore, present review investigated molecular mechanisms treatment different GI summarized drug delivery systems commonly used to improve their bioavailability. First, classification therapeutic various human diseases were briefly introduced. Then, clarify mechanism action body, metabolic process body associated signaling pathways causing five discussed, well corresponding targets flavonoids. Finally, clinical settings, poor water solubility, low permeability inferior stability, lead absorption efficiency vivo. three widely summarized. Suggestions for improving bioavailability focus next stage research also put forward.
Language: Английский