Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Language: Английский
International Journal of Polymeric Materials, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 17
Published: March 20, 2025
Language: Английский
Citations
0
Cancer Control, Journal Year: 2024, Volume and Issue: 31
Published: Jan. 1, 2024
Abnormalities in mitochondrial structure or function are closely related to the development of malignant tumors. Mitochondrial metabolic reprogramming provides precursor substances and energy for vital activities tumor cells, so that cancer cells can rapidly adapt unfavorable environment hypoxia nutrient deficiency. Mitochondria enable gain ability proliferate, escape immune responses, develop drug resistance by altering constitutive junctions, oxidative phosphorylation, stress, subcellular relocalization. This greatly reduces rate effective clinical control
Language: Английский
Citations
2
Cancer & Metabolism, Journal Year: 2024, Volume and Issue: 12(1)
Published: Oct. 28, 2024
Abstract Chemoresistance remains a major challenge in the effective treatment of colorectal cancer (CRC), contributing to poor patient outcomes. While molecular mechanisms underlying chemoresistance are complex and multifaceted, emerging evidence suggests that altered mitochondrial function hormone signaling play crucial roles. In this study, we investigated role CYP19A1, key enzyme estrogen biosynthesis, regulating CRC. Using combination vitro functional assays, transcriptomic analysis, clinical data mining, demonstrate CYP19A1 expression is significantly upregulated CRC cells patient-derived samples compared normal controls. Mechanistically, found regulates through modulation I activity, which mediated by CYP19A1-dependent biosynthesis. Notably, targeted inhibition using specific inhibitors effectively reversed chemotherapeutic drugs. Moreover, analysis TCGA dataset revealed high correlates with overall survival chemotherapy-treated patients. Taken together, our findings uncover novel for signaling, highlight potential targeting CYP19A1/estrogen/complex axis as therapeutic strategy overcome improve
Language: Английский
Citations
0
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: Dec. 23, 2024
Mitochondria are essential double-membrane organelles with intricate structures and diverse functions within cells. Under normal physiological conditions, mitochondria regulate cellular metabolism maintain energy homeostasis via the electron transport chain, mediate stem cell fate, modulate reactive oxygen species production, playing a pivotal role in supply lifespan extension. However, mitochondrial dysfunction can lead to various pathological changes, including aging, necrosis, dysregulated tumor immunity, initiation progression of cancer. Moreover, abnormal is closely associated numerous diseases, such as neurodegenerative disorders, metabolic syndromes, cancers. In recent years, targeting has emerged promising anticancer strategy, aiming for therapeutic benefits. Nonetheless, approaches face limitations, low delivery efficiency insufficient specificity. This review systematically explores structure function, their roles, potential challenges mitochondria-targeted strategies cancer therapy, providing insights future research directions.
Language: Английский
Citations
0
Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Language: Английский
Citations
0