The Hallmarks of Ageing in Human Immunodeficiency Virus Infection and the Impact of Antiretroviral Therapy on Telomeres: A Molecular Perspective DOI Creative Commons

Miruna-Maria Apetroaei,

Stella Baliou, Πέτρος Ιωάννου

et al.

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(4), P. 273 - 273

Published: April 12, 2025

Ageing is a complex and unavoidable physiological process which, in simple terms, consists of progressive deterioration the functionality cells, tissues organs, culminating an increased risk developing chronic pathologies. Telomeres, repetitive nucleotide structures at end chromosomes, ensure genomic integrity modulate cellular senescence. The shortening telomere length with each cell division directly correlates susceptibility to However, this shortening, normally inevitable, can be markedly accelerated presence infections, such as HIV-1 infection, by sustained continuous activation immune system, inflammation, generation oxidative stress, or direct alterations produced viral proteins. Thus, narrative review, we discuss 12 hallmarks ageing context understanding molecular changes induced through these well-established pillars could provide holistic approach management HIV-positive patients. At same time, considering that telomeres are centre all changes, assessment impact antiretroviral therapy on necessary guide clinical decisions. ultimate goal research develop personalised therapies increase quality life health outcomes HIV

Language: Английский

The Hallmarks of Ageing in Human Immunodeficiency Virus Infection and the Impact of Antiretroviral Therapy on Telomeres: A Molecular Perspective DOI Creative Commons

Miruna-Maria Apetroaei,

Stella Baliou, Πέτρος Ιωάννου

et al.

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(4), P. 273 - 273

Published: April 12, 2025

Ageing is a complex and unavoidable physiological process which, in simple terms, consists of progressive deterioration the functionality cells, tissues organs, culminating an increased risk developing chronic pathologies. Telomeres, repetitive nucleotide structures at end chromosomes, ensure genomic integrity modulate cellular senescence. The shortening telomere length with each cell division directly correlates susceptibility to However, this shortening, normally inevitable, can be markedly accelerated presence infections, such as HIV-1 infection, by sustained continuous activation immune system, inflammation, generation oxidative stress, or direct alterations produced viral proteins. Thus, narrative review, we discuss 12 hallmarks ageing context understanding molecular changes induced through these well-established pillars could provide holistic approach management HIV-positive patients. At same time, considering that telomeres are centre all changes, assessment impact antiretroviral therapy on necessary guide clinical decisions. ultimate goal research develop personalised therapies increase quality life health outcomes HIV

Language: Английский

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