Reduction of Alcohol-Dependent Lung Pathological Features in Rats Treated with Fenofibrate DOI Open Access
Diego Rojas,

Krishna Coronado,

Diliana Pérez-Reytor

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 12814 - 12814

Published: Nov. 28, 2024

Alcohol use disorder (AUD) is a public health problem characterized by marked increment in systemic inflammation. In the last few years, it has been described as role of alcohol neuroinflammation affecting some aspects neuronal function. Interestingly, inflammation reduced with fenofibrate treatment, PPARα agonist used to treat dyslipidemia. On other hand, associated chronic and fibrosis lungs, their normal function increasing respiratory infections. However, deep characterization worsening diseases not completely. this work, we present novel study using rats treated evaluate relevant features disease: inflammation, mucus hypersecretion, fibrosis. The analysis extracted lungs showed an inflammatory infiltrates pro-inflammatory cytokine levels alcohol. treatment decreased expression these markers observed lungs. mucin Muc5ac animals was markedly if were subsequently fenofibrate. Finally, documented collagen deposition around airways compared control animals. level similar These results pathological Moreover, attenuated due fibrate which allows us glimpse drug’s promising lung anti-inflammatory therapy.

Language: Английский

Artificial Intelligence-driven and technological innovations in the diagnosis and management of substance use disorders DOI

Daniela Lé Tassinari,

Maria Olívia Pozzolo Pedro, Manoela Pozzolo Pedro

et al.

International Review of Psychiatry, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 7

Published: Dec. 2, 2024

Substance Use Disorders (SUD) lead to a collection of health challenges such as overdoses and clinical diseases. Populations that are vulnerable lack straightforward treatment access significant economic social effects linked SUD. The ongoing advances in technology, especially Artificial Intelligence (AI), promise new ways reduce the SUD, refine standards, minimize risk relapse through tailored plans. Recent innovations functional neuroimaging techniques, fMRI, have led ability detect brain patterns associated with drug use, biomarkers blood testing provide crucial diagnostic support. In addition, digital platforms applied for behavioral assessment supported by AI natural language processing improve early recognition substance consumption trends, allowing targeted interventions reliant on real-time data. Using pharmacogenetics resources like mobile apps wearable devices makes development care programs continuously track mental health, physical changes possible. At core ethical issues related application SUD rights patients their privacy protected ensure all people justly these technologies. advancement models provides possibilities support judgment enhance patient outcomes

Language: Английский

Citations

2

Reduction of Alcohol-Dependent Lung Pathological Features in Rats Treated with Fenofibrate DOI Open Access
Diego Rojas,

Krishna Coronado,

Diliana Pérez-Reytor

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 12814 - 12814

Published: Nov. 28, 2024

Alcohol use disorder (AUD) is a public health problem characterized by marked increment in systemic inflammation. In the last few years, it has been described as role of alcohol neuroinflammation affecting some aspects neuronal function. Interestingly, inflammation reduced with fenofibrate treatment, PPARα agonist used to treat dyslipidemia. On other hand, associated chronic and fibrosis lungs, their normal function increasing respiratory infections. However, deep characterization worsening diseases not completely. this work, we present novel study using rats treated evaluate relevant features disease: inflammation, mucus hypersecretion, fibrosis. The analysis extracted lungs showed an inflammatory infiltrates pro-inflammatory cytokine levels alcohol. treatment decreased expression these markers observed lungs. mucin Muc5ac animals was markedly if were subsequently fenofibrate. Finally, documented collagen deposition around airways compared control animals. level similar These results pathological Moreover, attenuated due fibrate which allows us glimpse drug’s promising lung anti-inflammatory therapy.

Language: Английский

Citations

0