Childhood adversity predicts striatal functional connectivity gradient changes after acute stress DOI Creative Commons

Xiang-Shen Liu,

Koen V. Haak,

Karolina Figa

et al.

Imaging Neuroscience, Journal Year: 2024, Volume and Issue: 2, P. 1 - 13

Published: Jan. 1, 2024

Abstract As a primary risk factor for psychiatric vulnerability, childhood adversity (CA) leads to several maladaptive behavioral and brain functional changes, including domains of emotion, motivation, stress regulation. Previous studies on acute identified the potential role striatum-centered network in revealing psychopathology outcomes related CA. To elucidate interplay between CA, stress, striatal functions disorders, more evidence from large-scale connectivity diverse populations is necessary. In sample combining 150 patients 26 controls, we utilized “connectopic gradients” capture topographic organizations during resting-state scans conducted before after induction. Connectivity gradients rest under were linked different CA types their frequency by Spearman correlation. Linear mixed models moderation built clarify symptom strengths these correlations. We found one type CA—emotional neglect negatively predicted post-stress-induction gradient shape, reactive changes anterior-posterior orientation first-order gradient. Moderation revealed observed correlations selectively present individuals with elevated comorbidity. Our results may provide new psychopathology-related biomarkers tracking stress-induced general motivation systems. This demonstrates perspectives characterizing understanding its alterations response adverse experiences.

Language: Английский

Nucleus Accumbens Core Dopamine D2 Receptor-Expressing Neurons Control Reversal Learning but Not Set-Shifting in Behavioral Flexibility in Male Mice DOI Creative Commons
Tom Macpherson, Ji Yoon Kim, Takatoshi Hikida

et al.

Frontiers in Neuroscience, Journal Year: 2022, Volume and Issue: 16

Published: June 28, 2022

The ability to use environmental cues flexibly guide responses is crucial for adaptive behavior and thought be controlled within a series of cortico-basal ganglia-thalamo-cortical loops. Previous evidence has indicated that different prefrontal cortical regions control dissociable aspects behavioral flexibility, with the medial cortex (mPFC) necessary shift attention novel strategy (set-shifting) orbitofrontal (OFC) shifting between learned stimulus-outcome associations (reversal learning). nucleus accumbens (NAc) major downstream target both mPFC OFC; however, its role in controlling reversal learning set-shifting abilities still unclear. Here we investigated contribution two NAc neuronal populations, medium spiny neurons expressing either dopamine D1 or D2 receptors (D1-/D2-MSNs), guiding an attentional task (ASST). Persistent inhibition neurotransmitter release from D2-MSNs, but not D1-MSNs, resulted impaired learning, male mice. These findings suggest D2-MSNs play critical suppressing responding toward specific are now associated unfavorable outcomes (i.e., stages), suppression more general strategies set-shifting). This study provides further anatomical separation

Language: Английский

Citations

5
Evidence for absence of links between striatal dopamine synthesis capacity and working memory capacity, spontaneous eye-blink rate, and trait impulsivity DOI Creative Commons
Ruben van den Bosch, Frank H. Hezemans, Jessica I. Määttä

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2022, Volume and Issue: unknown

Published: July 11, 2022

Abstract Individual differences in striatal dopamine synthesis capacity have been associated with working memory capacity, trait impulsivity and spontaneous eye-blink rate (sEBR), as measured readily available easily administered, ‘off-the-shelf’ tests. Such findings raised the suggestion that individual variation estimated expensive invasive brain positron emission tomography (PET) scans, can be approximated simple, more pragmatic However, direct evidence for relationship between these simple measures has limited inconclusive. We using [ 18 F]-FDOPA PET a large sample of healthy volunteers (N=94) assessed correlation short tests impulsivity, sEBR. additionally explored an index subjective reward sensitivity. None correlated significantly nor did they out-of-sample predictive power. Bayes Factor analyses indicated was favour absence correlations all but These results warrant caution off-the-shelf proxies capacity.

Language: Английский

Citations

4
Frequency of DÉJÀ VU Experience and Its Relationship with Stress in Students of The Medical University of Islamabad DOI Creative Commons
Mehwish Riaz,

Hafiz Muhammad Hamza,

Khawaja Uzair Nayab

et al.

Journal of Rawalpindi Medical College, Journal Year: 2024, Volume and Issue: 28(1)

Published: March 30, 2024

Objective: This research aims to evaluate the frequency of déjà vu experience in medical students and its relationship with stress along different prognostic factors that lead experience. Methods: A descriptive cross-sectional study was conducted at Foundation University Islamabad over 4 months from May 2023 August 2023. The sample size (239) calculated using open Epi software a previous prevalence 67%. Stratified random sampling used select students. Data collected through questionnaire containing demographic variables validated inventory tool. Analysis done on perceived scale 10. SPSS 26 assess between chi-square test, statistical significance p<0.05. Results: 89.2% participants reported they had experienced this sensation least once their life. most popular ways feeling happened were certain place or situation. association Déjà experiences found be significant(p-value 0.012) Conclusion: once. There significant among university Keywords: vu, Stress, Familiarity, Sensation, Epilepsy, Dopamine.

Language: Английский

Citations

0
D-Ribose-L-Cysteine and L-Dopa Co-Supplementation Attenuates Paraquat-Induced Oxidative Damage and Locomotion Deficit in Drosophila melanogaster DOI
Adeola Oluwatosin Adedara, Grace Temitope Akingbade

Neurochemical Journal, Journal Year: 2024, Volume and Issue: 18(1), P. 233 - 242

Published: March 1, 2024

Language: Английский

Citations

0
Childhood adversity predicts striatal functional connectivity gradient changes after acute stress DOI Creative Commons

Xiang-Shen Liu,

Koen V. Haak,

Karolina Figa

et al.

Imaging Neuroscience, Journal Year: 2024, Volume and Issue: 2, P. 1 - 13

Published: Jan. 1, 2024

Abstract As a primary risk factor for psychiatric vulnerability, childhood adversity (CA) leads to several maladaptive behavioral and brain functional changes, including domains of emotion, motivation, stress regulation. Previous studies on acute identified the potential role striatum-centered network in revealing psychopathology outcomes related CA. To elucidate interplay between CA, stress, striatal functions disorders, more evidence from large-scale connectivity diverse populations is necessary. In sample combining 150 patients 26 controls, we utilized “connectopic gradients” capture topographic organizations during resting-state scans conducted before after induction. Connectivity gradients rest under were linked different CA types their frequency by Spearman correlation. Linear mixed models moderation built clarify symptom strengths these correlations. We found one type CA—emotional neglect negatively predicted post-stress-induction gradient shape, reactive changes anterior-posterior orientation first-order gradient. Moderation revealed observed correlations selectively present individuals with elevated comorbidity. Our results may provide new psychopathology-related biomarkers tracking stress-induced general motivation systems. This demonstrates perspectives characterizing understanding its alterations response adverse experiences.

Language: Английский

Citations

0