Proteins Associated with Neurodegenerative Diseases: Link to DNA Repair DOI Creative Commons
С. Н. Ходырева, Nadezhda S. Dyrkheeva, Olga I. Lavrik

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(12), P. 2808 - 2808

Published: Dec. 11, 2024

The nervous system is susceptible to DNA damage and repair defects, if not repaired, neuronal cells can die, causing neurodegenerative diseases in humans. overall picture of what known about mechanisms the still unclear. current challenge use accumulated knowledge basic science on improve treatment disorders. In this review, we summarize understanding function repair, particular, base excision double-strand break pathways as being most important cells. We recent data proteins involved associated with diseases, particular emphasis PARP1 ND-associated proteins, which are have ability undergo liquid–liquid phase separation.

Language: Английский

Proteins Associated with Neurodegenerative Diseases: Link to DNA Repair DOI Creative Commons
С. Н. Ходырева, Nadezhda S. Dyrkheeva, Olga I. Lavrik

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(12), P. 2808 - 2808

Published: Dec. 11, 2024

The nervous system is susceptible to DNA damage and repair defects, if not repaired, neuronal cells can die, causing neurodegenerative diseases in humans. overall picture of what known about mechanisms the still unclear. current challenge use accumulated knowledge basic science on improve treatment disorders. In this review, we summarize understanding function repair, particular, base excision double-strand break pathways as being most important cells. We recent data proteins involved associated with diseases, particular emphasis PARP1 ND-associated proteins, which are have ability undergo liquid–liquid phase separation.

Language: Английский

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