Research on the application of CRISPR technology in the treatment of type 1 diabetes (T1D) DOI Creative Commons
Mingyi Chen, Juntong Liu,

L Zhang

et al.

Theoretical and Natural Science, Journal Year: 2025, Volume and Issue: 82(1), P. 19 - 26

Published: Jan. 15, 2025

Diabetes is a chronic disease with rapid increase in incidence, which general problem around the world. Two main types of diabetes are included. Polygenic includes type 1 (T1D) and 2 (T2D), their monogenic forms juvenile mature (MODY) neonatal (NDM). CRISPR technology gene therapy low cost but very high feasibility. At present, researchers have envisioned use treatment T1D, this has off-target rate, immune rejection no abundant clinical trials human body to verify technology, resulting fact that not really used treatment. In middle. This article mainly analyzes summarizes problems solutions encountered by CRISPR-cas9 from basic theory idealized models. provides new for T1D also references technology. addition, such as been solved. Future research can focus on solution suppression cellular after impact re-mutation.

Language: Английский

Research on the application of CRISPR technology in the treatment of type 1 diabetes (T1D) DOI Creative Commons
Mingyi Chen, Juntong Liu,

L Zhang

et al.

Theoretical and Natural Science, Journal Year: 2025, Volume and Issue: 82(1), P. 19 - 26

Published: Jan. 15, 2025

Diabetes is a chronic disease with rapid increase in incidence, which general problem around the world. Two main types of diabetes are included. Polygenic includes type 1 (T1D) and 2 (T2D), their monogenic forms juvenile mature (MODY) neonatal (NDM). CRISPR technology gene therapy low cost but very high feasibility. At present, researchers have envisioned use treatment T1D, this has off-target rate, immune rejection no abundant clinical trials human body to verify technology, resulting fact that not really used treatment. In middle. This article mainly analyzes summarizes problems solutions encountered by CRISPR-cas9 from basic theory idealized models. provides new for T1D also references technology. addition, such as been solved. Future research can focus on solution suppression cellular after impact re-mutation.

Language: Английский

Citations

0