Food & Function, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 23, 2024
Astaxanthin extends the lifespan and health span of C. elegans . elevates skn-1 expression oxidative stress resistance in The extension by astaxanthin depends on PHA-4-mediated autophagy.
Language: Английский
Advances in Redox Research, Journal Year: 2024, Volume and Issue: 13, P. 100113 - 100113
Published: Aug. 31, 2024
Language: Английский
Citations
10
Endocrinology, Journal Year: 2024, Volume and Issue: 165(4)
Published: Feb. 17, 2024
Abstract Polycystic ovary syndrome (PCOS) is a common endocrine disorder associated with infertility and poor reproductive outcomes. The follicular fluid (FF) microenvironment plays crucial role in oocyte development. This review summarizes evidence elucidating the alterations FF composition PCOS. Various studies demonstrated pronounced proinflammatory milieu PCOS FF, characterized by increased levels of cytokines, including but not limited to interleukin-6 (IL-6), tumor necrosis factor α, C-reactive protein, IL-1β, concomitant reduction anti-inflammatory IL-10. T lymphocytes antigen-presenting cells are dysregulated FF. exhibit heightened reactive oxygen species production accumulation lipid peroxidation byproducts, impaired antioxidant defenses. Multiple microRNAs disrupting signaling critical granulosa cell function. Proteomic analysis reveals changes pathways related immune responses, metabolic perturbations, angiogenesis, hormone regulation. Metabolomics identify disturbances glucose metabolism, amino acids, profiles, steroid Collectively, these pathological may adversely affect quality, embryo development, fertility Further research on larger cohorts needed validate findings forge development prognostic biomarkers developmental competence within Characterizing environment key mechanisms underlying subfertility this challenging disorder.
Language: Английский
Citations
8
Antioxidants, Journal Year: 2024, Volume and Issue: 13(5), P. 522 - 522
Published: April 26, 2024
This study aimed to assess the influence of varying dietary levels astaxanthin (AST) on growth, antioxidant capacity and lipid metabolism juvenile swimming crabs. Six diets were formulated contain different AST levels, analyzed concentration in experimental 0, 24.2, 45.8, 72.4, 94.2 195.0 mg kg−1, respectively. Juvenile crabs (initial weight 8.20 ± 0.01 g) fed these for 56 days. The findings indicated that color live crab shells cooked gradually became red with increase levels. Dietary 24.2 kg−1 significantly improved growth performance crab. lowest activities glutathione (GSH), total (T-AOC), superoxide dismutase (SOD) peroxidase (POD) found without supplementation diet. Crabs diet showed lower content activity fatty acid synthetase (FAS) hepatopancreas than those supplementation, however, muscle carnitine palmitoyl transferase (CPT) not affected by And it can be oil O staining 45.8 promoted accumulation hepatopancreas. exhibited expression ampk, foxo, pi3k, akt nadph other diets, genes related such as cMn-sod, gsh-px, cat, trx gst down-regulated In conclusion, im-proved immune hemolymph.
Language: Английский
Citations
8
Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 28, 2024
Language: Английский
Citations
7
Aquatic Toxicology, Journal Year: 2024, Volume and Issue: 272, P. 106957 - 106957
Published: May 17, 2024
Language: Английский
Citations
6
Journal of Contaminant Hydrology, Journal Year: 2024, Volume and Issue: 261, P. 104299 - 104299
Published: Jan. 13, 2024
The skeletal muscle is a highly plastic tissue. Its ability to respond external stimuli and challenges allows it face the functional needs of organism. In goldfish Carassius auratus, model hypoxia resistance, exposure reduced oxygen accompanied by an improvement swimming performance, relying on sustained contractile behavior muscle. At moment, limited information available mechanisms underlying these responses. We here evaluated effects short- (4 days) long- (20 term moderate water white muscle, focusing oxidative status mitochondrial dynamics. No differences in lipid peroxidation, measured as 2-thiobarbituric acid-reacting substances (TBARS), oxidatively modified proteins (OMP) were detected animals exposed with respect their normoxic counterparts. Exposure short-term was characterized enhanced SOD activity expression, paralleled increased levels Nrf2, regulator antioxidant cell response, HSP70, chaperone also acting redox sensor. expression markers biogenesis (TFAM) abundance (VDAC) mtDNA/nDNA ratio similar under normoxia both long-term hypoxia, thus excluding rearrangement apparatus. Only increase PGC1α (a transcription factor involved dynamics) after 20 days hypoxia. Our results revealed novel aspects molecular that may sustain response contributing adequate tissue function organism requirements.
Language: Английский
Citations
5
Antioxidants, Journal Year: 2024, Volume and Issue: 13(3), P. 276 - 276
Published: Feb. 24, 2024
UVA radiation leads to oxidative stress and inflammation in skin cells. Therefore, the aim of this study was compare effect lipid extracts from microalgae Nannochloropsis oceanica (N.o.) (marine) Chlorococcum amblystomatis (C.a.) (freshwater) on redox balance PUFA metabolism human fibroblasts modified by UVA. Lipid both types introduced into fibroblast medium after irradiation significantly reduced level ROS enhanced expression Nrf2, which increased activity/level antioxidants (SOD1/2, CAT, GSH, Trx). The reduction accompanied a decrease 4-HNE, its protein adducts carbonyl groups. Microalgae also activity COX1/2, FAAH MAGL UVA, as consequence, mediators (especially N.o.) decreased, group endocannabinoids (AEA, 2-AG, PEA) eicosanoids (PGE2, 15d-PGJ2, TXB2, 15-HETE), acting mainly through receptors related G protein, increases This further contributed pro-inflammatory signaling at NF-κB TNFα levels. it is suggested that N.o. C.a. can be used regenerate disturbed radiation.
Language: Английский
Citations
5
Brain and Behavior, Journal Year: 2025, Volume and Issue: 15(3)
Published: Feb. 28, 2025
ABSTRACT Background This study investigates the role of KEAP1‐NRF2/HO‐1 signaling pathway in inducing ferroptosis and contributing to neuronal damage schizophrenia. Methods We retrieved schizophrenia‐related data ferroptosis‐related genes from RNA microarray dataset GSE27383 FerrDB database, respectively. Bioinformatics identified KEAP1 as a downregulated gene, which was validated using qRT‐PCR Western blot. assessed intracellular Fe 2 ⁺ content, MDA levels, GSH, GPX4 prefrontal cortex peripheral blood mononuclear cells (PBMCs) patients with Cortical interneurons (cINs) were generated human‐induced pluripotent stem (hiPSCs) schizophrenia used explore alterations during neurodevelopment. In addition, overexpression induced cINs via transfection pcDNA KEAP1. The Fe⁺ oxidative stress indicators, lipid peroxidation, inflammatory cytokines measured after transfection. To investigate molecular mechanisms, KI696—a high‐affinity probe that disrupts KEAP1–NRF2 interaction—was applied, changes stress, peroxidation (C11‐BODIPY staining), iron metabolism, pathways evaluated. Results Patients exhibited underexpression KEAP1, key regulator ferroptosis, along elevated levels increased concentrations, indicating enhanced stress. Reduced activity GSH also observed, suggesting an susceptibility ferroptosis. further this, derived hiPSCs studied. These showed decreased expression. Overexpression led reduction concentrations damage, highlighting KEAP1's regulatory treatment KI696 significant related antioxidant defenses, inflammation. Conclusion Our findings indicate contributes injury
Language: Английский
Citations
0
ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown
Published: March 16, 2025
Astaxanthin is an antioxidant with extremely high activity. However, the stability and solubility of free astaxanthin are poor. Therefore, we prepared astaxanthin-betaine (ASTA-Bet) ionic liquid liposomes through a combination theoretical calculations experimental research studied their physicochemical properties biological effects. This liposome has good skin permeability. The cumulative permeability ASTA-Bet 22.95 times that 2.41 liquid. particle size was 117.2 nm, did not change significantly after 28 days storage, indicating stability. Compared astaxanthin, activity can exert anti-inflammatory effects by regulating TGF-β1/smad2/smad3 pathway damaged ultraviolet radiation, which may contribute to resistance radiation damage. it be used as raw material develop cosmetics antiaging functions.
Language: Английский
Citations
0
Journal of Food Science, Journal Year: 2025, Volume and Issue: 90(4)
Published: April 1, 2025
Effective anti-aging strategies involving dietary restriction and antioxidant supplementation are gaining increasing research attention, while the health effects of their combined intervention rarely reported. In this study, for first time, we investigated underlying mechanisms intermittent fasting (IF), astaxanthin (AX), combination in D-galactose-induced aging rats. Our results demonstrated that these three treatments effectively inhibited malondialdehyde levels improved activity endogenous enzymes brain, liver, serum Simultaneously, IF AX had a synergistic effect on recovery brain mitochondrial injury as evidenced by permeability transition pore openness, membrane potential, respiratory chain complex enzyme activity, cortical hippocampal lesions. Notably, significantly increased Immunoglobulin M (55.66 ± 3.23%), immunoglobulin G (34.41 2.65%), IL-2 (23.49 1.78%) compared with model group. Moreover, reduced accumulation pro-inflammatory factor IL-6 (23.06 2.02%), induced more remarkable reduction IL-1β (35.92 3.06%) serum. Considering metabolomics analysis, hypothesized played positive role regulation nervous system, which was associated differential metabolites lysope 16:0, N-Acety-L-tyrosine, L-Alanyl-L-Lysine. This reveals therapy provided efficacy enhancing resistance to oxidative stress, ameliorating dysfunction, restoring immune system. These findings might have significant implications further studies exploration effective therapy.
Language: Английский
Citations
0