Traditional Chinese Medicine: An Important Coping Strategy with Challenges of Radiation Injury DOI Creative Commons
Shuai Shao, Yue Gao

Acupuncture and Herbal Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 13, 2024

People turn nervous when mention is made of radiation injuries, which cause multiple organ morbidities and are difficult to manage. However, the discovery antiradiation drugs remains challenging. Traditional Chinese medicine (TCM) may be an effective treatment strategy because its overall regulation. Herein, we systematically review TCM formulae, herbs, natural products as potential candidates. At same time, categorize them by their characteristics target organs. In addition, ingredients used block absorption accelerate excretion radionuclides considered in this review. To better manage scientific basis for radioprotection requires further in-depth research.

Language: Английский

Mechanisms of radiation‐induced tissue damage and response DOI Creative Commons

Zhou Lin,

Jiaojiao Zhu, Yuhao Liu

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(10)

Published: Sept. 20, 2024

Radiation-induced tissue injury (RITI) is the most common complication in clinical tumor radiotherapy. Due to heterogeneity response of different tissues radiation (IR), radiotherapy will cause types and degrees RITI, which greatly limits application Efforts are continuously ongoing elucidate molecular mechanism RITI develop corresponding prevention treatment drugs for RITI. Single-cell sequencing (Sc-seq) has emerged as a powerful tool uncovering mechanisms identifying potential targets by enhancing our understanding complex intercellular relationships, facilitating identification novel cell phenotypes, allowing assessment spatiotemporal developmental trajectories. Based on comprehensive review we analyzed regulatory networks combination with Sc-seq summarized targeted intervention pathways therapeutic Deciphering diverse underlying can shed light its pathogenesis unveil new avenues potentially facilitate repair or regeneration currently irreversible Furthermore, discuss how personalized strategies based offer promise mitigating

Language: Английский

Citations

5
Morin hydrate rebalances the miR-34a/Sirt1/HMGB1 pathway and abrogates radiation- induced nephritis via targeting Nrf2- miR-125b axis DOI
Rania A. Gawish, Esraa M. Samy,

Maha M. Aziz

et al.

Archives of Biochemistry and Biophysics, Journal Year: 2025, Volume and Issue: 766, P. 110345 - 110345

Published: Feb. 18, 2025

Language: Английский

Citations

0
Role of ferroptosis in radiation-induced soft tissue injury DOI Creative Commons

Charlotte E. Berry,

Carter B. Kendig,

Nicholas An

et al.

Cell Death Discovery, Journal Year: 2024, Volume and Issue: 10(1)

Published: July 5, 2024

Ionizing radiation has been pivotal in cancer therapy since its discovery. Despite therapeutic benefits, IR causes significant acute and chronic complications due to DNA damage the generation of reactive oxygen species, which harm nucleic acids, lipids, proteins. While cells are more vulnerable ionizing their inefficiency repairing damage, healthy irradiated area also suffer. Various types cell death occur, including apoptosis, necrosis, pyroptosis, autophagy-dependent death, immunogenic ferroptosis. Ferroptosis, driven by iron-dependent lipid peroxide accumulation, recognized as crucial therapy's effects complications, with extensive research across various tissues. This review aims summarize pathways involved radiation-related ferroptosis, findings different organs, drugs targeting ferroptosis mitigate harmful effects.

Language: Английский

Citations

3
Bee Pollen Potential to Modulate Ferroptosis: Phytochemical Insights for Age-Related Diseases DOI Creative Commons

Rachid Kacemi,

María G. Campos

Antioxidants, Journal Year: 2025, Volume and Issue: 14(3), P. 265 - 265

Published: Feb. 25, 2025

Bee pollen (BP) is one of the richest known natural resources micronutrients and bioactive phytochemicals. Some captivating bioactivities BP compounds, although being largely investigated for latter as individual molecules, remain very scarcely or completely uninvestigated in bee a whole product. Among most intriguing these bioactivities, we identified ferroptosis major one. Ferroptosis, recently discovered form cell death (connecting oxidative stress inflammation), complex pathophysiological process crucial perplexing events current challenging human diseases such cancer, neurodegeneration, general aging diseases. Many compounds were found to intricately modulate depending on cellular context by inducing this mechanism malignant cells preventing it non-malignant cells. Since research both fields, i.e., ferroptosis, still recent, deemed necessary undertake review figure out extent potential modulating mechanisms. Our proved that wide range (polyphenols, phenolamides, carotenoids, vitamins, minerals, others) substantially diverse Accordingly, phytochemicals nutrients showed interesting preclinical studies lead ferroptosis-mediated outcomes important processes, including many aging-related disorders. One paramount challenges be resolved determine how different act biological contexts, either through synergistic antagonistic behaviors. We hope our work constitutes valuable incentive future investigations promising relevant avenue.

Language: Английский

Citations

0
Solid-State Fermented Cereals: Increased Phenolics and Their Role in Attenuating Liver Diseases DOI Open Access
Ganesha Yanuar Arief Wijaya, Andrea Vornoli,

Lucia Giambastiani

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(5), P. 900 - 900

Published: March 4, 2025

Liver diseases, a leading cause of global mortality, necessitate effective dietary strategies. Fermented cereals, traditionally recognized for benefits in glucose regulation, lipid profiles, and antioxidant activity, hold potential managing conditions such as type 2 diabetes, hypertension, obesity. However, their specific impact on liver health requires further investigation. Fermentation, particularly solid-state fermentation (SSF), enhances the bioavailability beneficial compounds, including phenolics. This review summarizes recent studies phenolic content fermented highlighting variations based microbial strains cereal types. It examines hepatoprotective effects these phenolics, drawing vivo vitro research. Furthermore, explores findings cereals related diseases. work provides foundation future research exploring intervention disease prevention management.

Language: Английский

Citations

0
JAK/STAT signaling as a key regulator of ferroptosis: mechanisms and therapeutic potentials in cancer and diseases DOI Creative Commons

Yimeng Dai,

Chunguo Cui,

Dan Jiao

et al.

Cancer Cell International, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 7, 2025

Ferroptosis is a distinct form of regulated cell death characterized by iron-dependent lipid peroxidation, playing critical role in various diseases, including cancer, neurodegeneration, and tissue damage. This study reviews the intricate relationship between ferroptosis Janus kinase/signal transducer activator transcription (JAK/STAT) signaling pathway, highlighting its regulatory functions across multiple biological processes. Dysregulation JAK/STAT pathway implicated promoting or inhibiting ferroptosis, depending on context. JAK2 promotes activating STAT proteins, modulating expression key regulators like SLC7A11 GPX4, influencing iron homeostasis through pathways such as ferritinophagy hepcidin regulation. STAT1 activation primarily enhances suppression cystine-glutamate antiporter (System Xc-), leading to glutathione depletion contributing conditions Sjogren's syndrome age-related macular degeneration. In contrast, STAT3 plays protective upregulating which inhibits survival, particularly cancers hepatocellular carcinoma, prostate renal carcinoma. also discusses STAT6's involvement diseases asthma lung injury regulating antioxidant defenses. Furthermore, review explores potential therapeutic strategies targeting manipulate for disease treatment. cancer therapy, this can enhance effectiveness inducers, offering promising avenues overcome drug resistance. Additionally, interplay immune responses, oxidative stress, metabolism underscores significance progression intervention. By exploring these mechanisms, provides insights into development novel treatments modulation, with implications inflammatory neurodegenerative conditions.

Language: Английский

Citations

0
Loss of Nrf2 aggravates ionizing radiation-induced intestinal injury by inhibiting the cGAS/STING pathway via Pirin DOI
Yiqing Xu, Lei Wang,

Hong Liao

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: 604, P. 217218 - 217218

Published: Sept. 3, 2024

Language: Английский

Citations

3
pH-dependent conformational transitions in ferulic acid and Nrf2-ferulic acid complex analyzed through spectroscopy and molecular dynamics simulations DOI

B.L. Amshumala,

Giovanni M. Pavan,

S J

et al.

Journal of Molecular Liquids, Journal Year: 2024, Volume and Issue: unknown, P. 126703 - 126703

Published: Dec. 1, 2024

Language: Английский

Citations

2
Integrated serum pharmacochemistry with network pharmacology and pharmacological validation to elucidate the mechanism of yiqitongmai decoction (YQTMD) against myocardial infarction DOI
Hao Yu, Ning Wang,

Xuerong Zhao

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 331, P. 118329 - 118329

Published: May 13, 2024

Language: Английский

Citations

1
Traditional Chinese Medicine: An Important Coping Strategy with Challenges of Radiation Injury DOI Creative Commons
Shuai Shao, Yue Gao

Acupuncture and Herbal Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 13, 2024

People turn nervous when mention is made of radiation injuries, which cause multiple organ morbidities and are difficult to manage. However, the discovery antiradiation drugs remains challenging. Traditional Chinese medicine (TCM) may be an effective treatment strategy because its overall regulation. Herein, we systematically review TCM formulae, herbs, natural products as potential candidates. At same time, categorize them by their characteristics target organs. In addition, ingredients used block absorption accelerate excretion radionuclides considered in this review. To better manage scientific basis for radioprotection requires further in-depth research.

Language: Английский

Citations

1