Archives of Biochemistry and Biophysics, Journal Year: 2024, Volume and Issue: 757, P. 110027 - 110027
Published: May 8, 2024
Language: Английский
Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(1), P. 104 - 104
Published: Jan. 15, 2025
Cytokine-mediated inflammation is increasingly recognized for playing a vital role in the pathophysiology of wide range brain disorders, including neurodegenerative, psychiatric, and neurodevelopmental problems. Pro-inflammatory cytokines such as interleukin-1 (IL-1), tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) cause neuroinflammation, alter function, accelerate disease development. Despite progress understanding these pathways, effective medicines targeting are still limited. Traditional anti-inflammatory immunomodulatory drugs peripheral inflammatory illnesses. Still, they face substantial hurdles when applied to central nervous system (CNS), blood-brain barrier (BBB) unwanted systemic effects. This review highlights developing treatment techniques modifying cytokine-driven focusing on advances that selectively target critical involved pathology. Novel approaches, cytokine-specific inhibitors, antibody-based therapeutics, gene- RNA-based interventions, sophisticated drug delivery systems like nanoparticles, show promise with respect lowering neuroinflammation greater specificity safety. Furthermore, developments biomarker discoveries neuroimaging improving our ability monitor responses, allowing more accurate personalized regimens. Preclinical clinical trial data demonstrate therapeutic potential tailored techniques. However, significant challenges remain, across BBB reducing off-target As research advances, creation personalized, cytokine-centered therapeutics has therapy landscape illnesses, giving patients hope better results higher quality life.
Language: Английский
Citations
1
Materials Today Bio, Journal Year: 2024, Volume and Issue: 26, P. 101101 - 101101
Published: May 29, 2024
Messenger ribonucleic acid (mRNA) has emerged as a promising molecular preventive and therapeutic approach that opens new avenues for healthcare. Although the use of delivery systems, especially lipid nanoparticles (LNPs), greatly improves efficiency stability mRNA, mRNA tends to accumulate in liver hardly penetrates physiological barriers reach target site after intravenous injection. Hence, rational design targeting strategies aimed at directing specific tissues cells remains an enormous challenge therapy. High-throughput screening (HTS) is cutting-edge targeted technique capable synthesizing chemical compound libraries large-scale experiments validate system. In this review, we firstly provide overview conventional low-throughput strategies. Then latest advancements HTS techniques delivery, encompassing optimizing structures vehicles developing surface ligands, well applications extrahepatic systemic diseases are comprehensively summarized. Moreover, illustrate selection administration routes delivery. Finally, challenges field potential solutions tackle them proposed, offering insights future development toward
Language: Английский
Citations
4
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142829 - 142829
Published: April 1, 2025
Exosomes are tiny extracellular membrane vesicles produced by various biological sources that have gained significant attention due to their theranostic potential. They carry macromolecules such as proteins, DNA, and RNA (including miRNAs) involved in intercellular communication within the central nervous system (CNS). This review summarizes role of exosomes miRNAs aspects depression, emphasizing therapeutic potential depression applications drug delivery systems. modulating critical pathways neurogenesis, synaptic plasticity, blood-brain barrier integrity, neuroinflammation, neural development. reduce neuroinflammation suppressing cytokine production immune activation. Furthermore, facilitate neuronal repair which is important for restoring circuitry, cognitive abilities, emotional mental stability affected depression. Moreover, exosomal emerging targets both diagnostic treatment perspectives treatment. The regulate gene expressions associated with functions health serve biomarkers novel approaches. In conclusion, may play a crucial will enhance probability successful
Language: Английский
Citations
0
Precision medicine and engineering., Journal Year: 2024, Volume and Issue: 1(2), P. 100010 - 100010
Published: Oct. 19, 2024
Language: Английский
Citations
3
Archives of Biochemistry and Biophysics, Journal Year: 2024, Volume and Issue: 757, P. 110027 - 110027
Published: May 8, 2024
Language: Английский
Citations
0