Research article for 1st revision to the Chemico-Biological InteractionModulatory roles of capsaicin on thermogenesis in C2C12 myoblasts and the skeletal muscle of mice

Chemico-Biological Interactions, Journal Year: 2025, Volume and Issue: unknown, P. 111380 - 111380

Published: Jan. 1, 2025

Language: Английский

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Computer-aided ligand identification of capsaicinoids and their potential functions in metabolic diseases

Molecular Diversity, Journal Year: 2025, Volume and Issue: unknown

Published: April 19, 2025

Language: Английский

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Lipid-based nano-carriers for the delivery of anti-obesity natural compounds: advances in targeted delivery and precision therapeutics

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: May 7, 2025

Obesity is a major global health challenge, contributing to metabolic disorders such as type 2 diabetes, cardiovascular diseases, and hypertension. The increasing prevalence of obesity, driven by sedentary lifestyles, poor dietary habits, genetic predisposition, underscores the urgent need for effective therapeutic strategies. Conventional pharmacological treatments, including appetite suppressants modulators, often fail provide sustainable weight loss due side effects, adherence, limited long-term efficacy. As result, natural bioactive compounds have gained attention their anti-obesity potential. However, clinical application hindered bioavailability, rapid metabolism, inefficient delivery. Lipid-based nano-carriers, liposomes, solid lipid nanoparticles, nanostructured carriers, offer promising solution enhancing solubility, stability, targeted delivery these compounds. These advanced systems improve retention, enable controlled release, enhance action on adipose tissue pathways. Additionally, functionalized stimulus-responsive nanocarriers present innovative approaches precision obesity treatment. Despite advancements, challenges remain in large-scale production, regulatory approval, safety. Overcoming barriers critical ensuring successful translation nano-formulated therapies. This review explores potential lipid-based nano-carriers optimizing efficacy highlights role advancing next-generation management

Language: Английский

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Complex networks interactions between bioactive compounds and adipose tissue vis-à-vis insulin resistance

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: May 13, 2025

Fatty acids disorders may lead to insulin resistance, resulting in long-term oxidative stress and inflammatory processes, both mediated by adipose tissue. Either normal condition or obesogenic status, cells components play an important role several physiological metabolic conditions. It has been shown that bioactive compounds can influence the development of obesity its pathological complications such as resistance. In this study, we performed a network between tissue vis-a-vis We constructed regulatory 62 adipocyte cell incorporates current evidence cellular molecular interactions involved healthy states. The incorporated information about inflammation pathways inhibition signaling; signaling GLUT 4 translocation; triglycerides production; ATP M2 macrophages recruitment; adipogenesis lipolysis well mitochondrial biogenesis. Our mathematical model showed discernment impact various substances on transitions from health vice versa. found anthocyanins, punicalagin, oleanolic acid, NRG4 proved be critical nodes transition state, due their switch-on potential up-regulate complex beneficial transition.

Language: Английский

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Molecular mechanisms of UCP1-independent thermogenesis: the role of futile cycles in energy dissipation

Journal of Physiology and Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: May 17, 2025

Language: Английский

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Capsaicin: a spicy way in liver disease

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 30, 2024

The incidence of liver disease continues to rise, encompassing a spectrum from simple steatosis or non-alcoholic fatty (NAFLD) steatohepatitis (NASH), cirrhosis and cancer. Dietary habits in individuals with may significantly impact the treatment prevention these conditions. This article examines role chili peppers, common dietary component, this context, focusing on capsaicin, active ingredient peppers. Capsaicin is an agonist transient receptor potential vanilloid subfamily 1 (TRPV1) has been shown exert protective effects diseases, including injury, NAFLD, fibrosis These are attributed capsaicin's anti-oxidant, anti-inflammatory, anti-steatosis anti-fibrosis effects. reviewed different molecular mechanisms effect capsaicin diseases.

Language: Английский

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Fatty acid composition, lipid profile and oxidative stability of meat of broiler chickens fed diet containing bird eye pepper of varying inclusion level and sieve size

Tropical Animal Health and Production, Journal Year: 2024, Volume and Issue: 56(8)

Published: Oct. 14, 2024

Language: Английский

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