The Keap1/Nrf2/ARE/HO-1 axis in epilepsy: Crosstalk between oxidative stress and neuroinflammation

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 153, P. 114304 - 114304

Published: March 20, 2025

Language: Английский

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Dihydromyricetin: an emerging compound with comprehensive effects on multiple systems

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 3, 2025

Dihydromyricetin (DHM or DMY) is a flavonoid derived from natural sources with range of confirmed biological benefits. It exhibits anti-inflammatory, antioxidant, anti-tumor, and anti-viral activities. DHM recognized for its high biosafety, making it promising subject further research. This article offers comprehensive overview DHM's pharmacological properties, mechanisms, recent research developments in the cardiovascular, urinary, digestive, nervous, respiratory systems. The review summarizes effects associated signaling pathways, providing novel insights clinical application.

Language: Английский

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Targeting the p38MAPK/STAT3/NF-κB65 pathway modulates the hepatoprotective effect of pentoxifylline against sodium valproate-induced liver injury in rats; A study based on integrating network pharmacology and experiment validation

Tissue and Cell, Journal Year: 2025, Volume and Issue: 96, P. 102942 - 102942

Published: May 9, 2025

Language: Английский

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Saroglitazar ameliorates 5- Fluorouracil-induced hepatorenal damage in rats

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 143, P. 113407 - 113407

Published: Oct. 17, 2024

Language: Английский

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