Bisphenol A Analogues in Food and Their Hormonal and Obesogenic Effects: A Review

Nutrients, Journal Year: 2019, Volume and Issue: 11(9), P. 2136 - 2136

Published: Sept. 6, 2019

Bisphenol A (BPA) is the most well-known compound from bisphenol family. As BPA has recently come under pressure, it being replaced by compounds very similar in structure, but data on occurrence of these analogues food and human matrices are limited. The main objective this work was to investigate exposure associated health effects. We performed a literature review available research made humans, vivo vitro tests. findings support idea that may have an impact health, especially terms obesity other adverse effects children.

Language: Английский

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Concentrations of bisphenol A and its alternatives in paired maternal–fetal urine, serum and amniotic fluid from an e-waste dismantling area in China

Environment International, Journal Year: 2020, Volume and Issue: 136, P. 105407 - 105407

Published: Jan. 16, 2020

Bisphenol A (BPA) and its alternatives are suspected endocrine disruptors. However, prenatal exposure transplacental transfer of bisphenols (BPs is still limited. Therefore, BPA six in maternal serum (MS), urine (MU), cord (CS), amniotic fluid (AF) samples collected from 106 maternal-fetal pairs an e-waste dismantling site Southern China were determined. AF (BPAF) bisphenol S (BPS) the dominant observed MS CS, geometric mean (GM) concentration BPAF (0.013 ng/mL MS, 0.097 CS) BPS (0.01 0.03 CS was lower than that (0.5 1.2 CS). The ratios concentrations between MU (MU:MS ratio) over three times higher those (AF:CS ratio), thereby suggesting low biotransformation/metabolism fetuses. placental rates BPs (i.e., CS:MS compound-specific (BPAF 3.26, 1.94, 1.11). Results suggest can pass through barrier. positively related to molecular weight or log Kow values. This finding indicates active transport responsible for BPs.

Language: Английский

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A miniaturized stir bar sorptive dispersive microextraction method for the determination of bisphenols in follicular fluid using a magnetic covalent organic framework

Analytica Chimica Acta, Journal Year: 2024, Volume and Issue: 1289, P. 342215 - 342215

Published: Jan. 4, 2024

Bisphenols, particularly bisphenol A (BPA), are the primary monomers used as additives in manufacturing of many consumer products. The exposure to these compounds is related endocrine-disrupting and reproductive effects, among others. For this reason, development analytical methods for their determination biological matrixes needed monitor population compounds. Their quantification at ovarian level (i.e., follicular fluid) interesting assessment content draw conclusions about infertility problems. However, background does not meet all requirements by focusing mainly on BPA.

Language: Английский

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Bisphenol AF and Bisphenol B Exert Higher Estrogenic Effects than Bisphenol A via G Protein-Coupled Estrogen Receptor Pathway

Environmental Science & Technology, Journal Year: 2017, Volume and Issue: 51(19), P. 11423 - 11430

Published: Aug. 31, 2017

Numerous studies have indicated estrogenic disruption effects of bisphenol A (BPA) analogues. Previous mechanistic were mainly focused on their genomic activities nuclear estrogen receptor pathway. However, nongenomic through G protein-coupled (GPER) pathway remain poorly understood. Here, using a SKBR3 cell-based fluorescence competitive binding assay, we found six BPA analogues bound to GPER directly, with AF (BPAF) and B (BPB) displaying much higher (∼9-fold) affinity than BPA. Molecular docking also demonstrated the these GPER. By measuring calcium mobilization cAMP production in cells, lead activation subsequent signaling pathways. Consistent results, BPAF BPB presented agonistic activity lowest effective concentration (LOEC) 10 nM. Moreover, based results Boyden chamber wound-healing assays, displayed promoting mediated cell migration LOEC 100 Overall, two could exert via at nanomolar concentrations.

Language: Английский

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The occurrence and source identification of bisphenol compounds in wastewaters

The Science of The Total Environment, Journal Year: 2017, Volume and Issue: 616-617, P. 744 - 752

Published: Dec. 24, 2017

This study reports the occurrence of eight bisphenols (BPs): bisphenol AF (BPAF), AP (BPAP), B (BPB), C (BPC), E (BPE), F (BPF), S (BPS) and Z (BPZ) in wastewaters (WWs). Sample preparation involved pre-concentration with SPE cartridges (Oasis HLB), followed by derivatization using N-(tert-butyldimethylsilyl)-N-methyltrifluoroacetamide 1% tert-butyldimethylchlorosilane. Chemical analysis was based on gas chromatography–mass spectrometry. A validated method limits detection (LODs) at ng L− 1 range applied to WWs collected five Slovene wastewater treatment plants (WWTPs) WW inflows from industrial, commercial residential sources entering sewerage systems two catchments (Domžale-Kamnik (DK) Ljubljana (LJ)). The presence all BPs confirmed three DK LJ catchments. High cumulative concentrations were determined food processing facilities (LJ: 3030 DK: 599 1). high frequency observed textile cleaning companies (6 for 8 DK). WWTPs revealed that only BPF (36.7 1) BPS (40.6 > LODs influents, whereas other detected also effluents. BPZ found highest concentration (403 WWTP-DK). this WWTP contained amount BPE (238 Although removal could not be directly compared between WWTPs, exception BPAP BPB case smaller (6.39%–43.2%) general highly removed (≥ 96.2%). Finally, levels BPC LOD are reported first time (WWTP catchment: 1.01 1–11.8 1; inflow plant up 2560

Language: Английский

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Exposure to bisphenols and parabens during pregnancy and relations to steroid changes

Environmental Research, Journal Year: 2018, Volume and Issue: 163, P. 115 - 122

Published: Feb. 22, 2018

Language: Английский

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Determination of bisphenols with estrogenic activity in plastic packaged baby food samples using solid-liquid extraction and clean-up with dispersive sorbents followed by gas chromatography tandem mass spectrometry analysis

Talanta, Journal Year: 2017, Volume and Issue: 178, P. 441 - 448

Published: Sept. 23, 2017

Language: Английский

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Dummy molecularly imprinted magnetic nanoparticles for dispersive solid-phase extraction and determination of bisphenol A in water samples and orange juice

Talanta, Journal Year: 2016, Volume and Issue: 162, P. 57 - 64

Published: Oct. 7, 2016

Language: Английский

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Impact of low-dose chronic exposure to bisphenol A and its analogue bisphenol B, bisphenol F and bisphenol S on hypothalamo-pituitary-testicular activities in adult rats: A focus on the possible hormonal mode of action

Food and Chemical Toxicology, Journal Year: 2018, Volume and Issue: 121, P. 24 - 36

Published: Aug. 16, 2018

Language: Английский

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Determination of selected bisphenols, parabens and estrogens in human plasma using LC-MS/MS

Talanta, Journal Year: 2017, Volume and Issue: 174, P. 21 - 28

Published: May 29, 2017

Language: Английский

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