The Impact of Melatonin on Oral Health: Current Insights and Future Research Directions DOI Creative Commons

Tasneem Alomari,

Omar Alomarı, Russel J. Reıter

et al.

Journal of Medicine Surgery and Public Health, Journal Year: 2024, Volume and Issue: unknown, P. 100151 - 100151

Published: Oct. 1, 2024

Language: Английский

Competitive enzyme linked aptamer based assay for salivary melatonin detection DOI Creative Commons

Meenakshi Pundir,

Liubov Lobanova,

Pétros Papagerakis

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 24, 2025

Melatonin is a key hormone that regulates the sleep-wake cycle and plays an important role in maintaining circadian rhythm sleep onset. The daily rise melatonin secretion associated with increased tendency to sleep, occurring approximately 2 h before bedtime. This correlation between levels onset makes it reliable biomarker for disorders. An accurate assessment of dim light (DLMO) vital understanding timing diagnosing disruptions. However, traditional methods detecting saliva are either complex or lack sensitivity required DLMO, especially at low concentrations. Here, we present novel competitive enzyme-linked aptamer-based assay developed detect saliva. Unlike conventional assays, this technique utilizes chemically synthesized single-stranded DNA RNA aptamers, which bind high specificity sensitivity. measures melatonin, attaining linear dynamic range from 8.62 × 10‒6 M 3.9 10‒11 M, detection limit 2.5 10‒12 (~ 0.57 pg/mL). Additionally, aptamer showed small binding its counter targets acceptable recovery when spiked four times diluted buffer. Overall, portrayed potential aptamers could be beneficial accurately determining particularly individuals very levels, such as elderly those neurodegenerative conditions. Determining precise measurement DLMO will facilitate diagnosis disruption, enabling healthcare providers optimize selection therapeutic behavioural interventions tailored individual's unique rhythm.

Language: Английский

Citations

0
Melatonin Interventions in Autism Spectrum Disorder: Sleep Regulation, Behavioral Outcomes, and Challenges Across the Lifespan DOI
Geir Bjørklund, Oleksandra Oleshchuk, Yana Ivankiv

et al.

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Language: Английский

Citations

0
Fluorimetric monitoring of vancomycin using an allosteric probe-initiated sensing platform DOI

Jinshan Yuan,

Guoming Xie, Junjie Li

et al.

Analytica Chimica Acta, Journal Year: 2023, Volume and Issue: 1269, P. 341431 - 341431

Published: May 25, 2023

Language: Английский

Citations

7
Colorimetric sensing assay based on aptamer-gold nanoparticles for rapid detection of salivary melatonin to monitor circadian rhythm sleep disorders DOI

Meenakshi Pundir,

Liubov Lobanova,

Silvana Papagerakis

et al.

Analytica Chimica Acta, Journal Year: 2023, Volume and Issue: 1279, P. 341777 - 341777

Published: Sept. 2, 2023

Language: Английский

Citations

4
Development of an Automated Capture-SELEX Device for Efficient Screening of β-Conglycinin Aptamer DOI

Yingming Zhang,

Shikun Zhang, Zhiyuan Ning

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 4, 2024

β-Conglycinin is the main allergen present in soybeans, and it causing wide concern due to its notable allergenicity, heat, digestive enzyme resistance. Screening for aptamers that both recognize β-conglycinin inhibit allergic reactions triggers necessary. Conventional aptamer screening labor-intensive, requires skilled personnel, has limited reproducibility. To address these limitations, an automated device was developed enhance efficiency of selection Capture-SELEX. The achieves highly integrated, reproducible, accurate contamination control. Using this device, a high-affinity specific aptamer, β-5, selected with

Language: Английский

Citations

1
Decoupling photonic and thermal contributions for photoelectrochemical sensing of melatonin via graphene oxide nanoribbons DOI Creative Commons
Chia‐Liang Sun, Hung‐Yu Chen, Mrinal Poddar

et al.

Electrochemistry Communications, Journal Year: 2023, Volume and Issue: 159, P. 107649 - 107649

Published: Dec. 15, 2023

Language: Английский

Citations

3
Emerging Biohybrids of Aptamer-Based Nano-Biosensing Technologies for Effective Early Cancer Detection DOI

Thimmaiah Bargavi Ram,

Saravanan Krishnan, Jaison Jeevanandam

et al.

Molecular Diagnosis & Therapy, Journal Year: 2024, Volume and Issue: 28(4), P. 425 - 453

Published: May 22, 2024

Language: Английский

Citations

0
Thermophoretic Assay for Biosensing DOI

Haixiang Ling,

Yunhe Yuan,

Fuli Chen

et al.

Advanced Materials Technologies, Journal Year: 2024, Volume and Issue: 9(13)

Published: March 30, 2024

Abstract Thermophoresis refers to the directional movement of particles driven by temperature gradients, which is ubiquitous in nature. This phenomenon can be conveniently used manipulate molecules and objects such as biomolecules, colloids, metal nanoparticles, cells. Because these advantages, thermophoresis widely biosensing. In vitro diagnosis, an important field biosensing, highly compatible with thermophoresis. Compared traditional diagnostic techniques, thermophoretic diagnosis a homogeneous system that boasts high efficiency rapid detection well wide range; thus, has myriad applications. The emergence microscale multifield coupling technologies yield widespread applications diagnostics. study presents history reviews various cases biosensors utilizing Those are diagnostics, biomarker discovery, other fields. Furthermore, it assesses advantages thermophoresis, finally discusses its current challenges future development.

Language: Английский

Citations

0
The Impact of Melatonin on Oral Health: Current Insights and Future Research Directions DOI Creative Commons

Tasneem Alomari,

Omar Alomarı, Russel J. Reıter

et al.

Journal of Medicine Surgery and Public Health, Journal Year: 2024, Volume and Issue: unknown, P. 100151 - 100151

Published: Oct. 1, 2024

Language: Английский

Citations

0