Solar energy-based electromembrane extraction using agarose gel for the determination of nonsteroidal anti-inflammatory drugs from biological samples: An environmentally friendly strategy

Journal of Chromatography A, Journal Year: 2023, Volume and Issue: 1706, P. 464233 - 464233

Published: July 20, 2023

Language: Английский

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Determination of Five Phosphodiesterase-5 Inhibitors in Multiple Honey-Based Consumer Products by Chromatographic Technique in Rat Plasma

Processes, Journal Year: 2023, Volume and Issue: 11(10), P. 3019 - 3019

Published: Oct. 20, 2023

This study aimed to develop and verify a simple HPLC-based quantitative approach simultaneously determine the phosphodiesterase-5 inhibitors (PDE5Is) sildenafil, vardenafil, udenafil, avanafil, tadalafil in tablet dosage form mixed with honey obtained Jordanian market rat plasma. PDE5Is block (PDE-5). blockage, turn, triggers vasodilation by phosphorylating downstream effector molecules. Chromatographic separation was performed on HypersilTM C18 column (150 mm × 4.6 mm, 5 µm, Thermo Fisher Inc., Waltham, MA, USA). An acetonitrile:10% Triethylamine solution (57:43) at pH 5.5 (adjusted orthophosphoric acid), 20 µL injection volume, 1 mL/min flow rate, 25 °C temperature, eluent monitoring 250 nm used execute current approach. Linearity observed 9.6–14.4 µg/mL concentration ranges for tadalafil, 2.4–3.6 vardenafil. Each recovered within acceptable limits three distinct concentrations, assay selectivity indicated no interference from inactive substances formulation. Sildenafil, had retention times of 3.5, 4.3, 6.2, 9.7, 12.8 min, respectively, min. The present analytical method is comprehensive universal measuring five drugs. Such an can be routinely detect combination these

Language: Английский

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Methamphetamine detection using portable capillary electrophoresis coupled with a swab-based extraction device

Talanta, Journal Year: 2024, Volume and Issue: 278, P. 126357 - 126357

Published: June 15, 2024

Methamphetamine (MA) is one of the most virulent illicit drugs that can be synthesized from household materials leading to its prevalent trafficking and local manufacturing in clandestine drug laboratories (clan labs). The significant problems tracing MA clan labs monitoring abusers lie lag time between sample collection analysis number tests done. Capillary electrophoresis (CE) a rapid separation technique amenable miniaturization field testing. Herein, we developed simple transient isotachophoretic (tITP)-CE method detect precursor pseudoephedrine (PSE) non-invasive biological fluids. was implemented on ETD-100, commercial fully automated portable CE instrument with an integrated swab-based extraction system. Within 2 min insertion swab, PSE were automatically extracted electrolyte (LE) then separated covalently modified capillaries. ETD-100 showed limit detection (LOD) quantification (LOQ) 0.02 0.05 μg/swab 0.06 PSE, enhancement factor 118 328, respectively, when compared normal non-tITP injection. intra inter-day relative standard deviation terms migration range 0.75-1.93 % for both 2.0-2.4 peak height. demonstrated spiked different as well fluids recovery above 60 %.

Language: Английский

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Capillary Electrophoresis in Food Analysis

Encyclopedia of Analytical Chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 27

Published: June 24, 2024

Abstract The development and application of faster more powerful analytical methodologies in Food Science is essential to face the demands from regulatory agencies, official laboratories, consumers. In this field, capillary electrophoresis (CE) nowadays a well‐established separation technique for food analysis that possesses exceptional properties related high speed efficiencies combined with small samples reagent requirements. Moreover, it very versatile since different CE modes can be employed broad range applications challenges. fact, should considered as first option when dealing highly polar, charged, or chiral analytes. past two decades, amount research work has been published, demonstrating potential analyze components variety matrices. aim article provide an overview use including summary characteristics main detectors mostly field. Besides, wide view latest (2021–2023) also provided, possibilities technique.

Language: Английский

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On-line sample pre-concentration in capillary electrophoresis: Fundamentals and computational simulation

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

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