Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: May 14, 2025
Electro-osmotic
micromixers
constitute
a
specialized
class
of
active
that
apply
alternating
current
(AC)
to
electrodes.
This
methodology
promotes
the
formation
vortical
structures
within
fluid
medium,
resulting
in
substantial
increase
mixing
homogeneity.
In
this
study,
geometrical
parameters
electro-osmotic
micromixer,
for
which
two
rigid
baffles
were
implanted
at
entrance,
optimized
using
Taguchi
method
and
response
surface
(RSM).
Data
obtained
through
transient
2D
model,
simulated
COMSOL
software
based
on
finite
element
method.
After
acquiring
geometric
parameters,
index
was
assessed
under
various
conditions,
including
inlet
velocity,
frequency,
voltage,
phase
lag
current.
The
values
first
baffle
angle
([Formula:
see
text]),
second
length
(L),
distance
between
x
direction
(x),
y
direction(y),
chamber
(α)
[Formula:
text]
resulted
10.58%
improvement
process
index.
implementation
improved
by
8%.
Furthermore,
increasing
applied
voltage
from
1
3
V
27%
average
enhancement
A
maximum
99.37%
achieved
lag,
representing
an
20.1%
compared
absence
lag.
reflects
approximate
65%
initial
stage
scenario
without
any
Lab on a Chip,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
The
proposed
Bayesian
optimization-based
approach
enhances
micromixer
performance
by
optimizing
geometric
parameters,
significantly
reducing
required
number
of
simulations,
and
accelerating
the
design
process
compared
to
conventional
methods.
Industrial & Engineering Chemistry Research,
Journal Year:
2024,
Volume and Issue:
63(6), P. 2861 - 2874
Published: Feb. 1, 2024
In
this
work,
passive
micromixers
that
consist
of
square
mixing
chambers
symmetrically
placed
along
the
length
mixer
are
investigated
for
miscible
fluids.
The
governing
equation
Navier–Stokes
and
convection–diffusion
were
resolved
using
finite
element
approach,
which
is
implemented
in
COMSOL
6.1
software
to
simulate
evaluate
effectiveness
mixers.
Different
design
configurations
evaluated
three
key
performance
parameters,
including
index,
pressure
drop,
energy
cost,
analyze
distinct
channel
types
curved,
square-wave,
zigzag
across
a
wide
range
Reynolds
numbers,
between
0.1
45.
study
also
behavior
diffusion
chaotic
advection,
results
showed
as
numbers
increase,
index
exhibits
an
initial
decrease
followed
by
increase.
Remarkably,
all
reach
great
99%
at
low
number
This
complete
accompanied
variations
drop
values,
where
SCC
has
smaller
compared
SCS-W
SCZ
mixers,
with
decreases
74.26
30.70%,
respectively.
Comparing
suggested
previously
published
micromixers,
it
more
compact
easier
manufacturing
procedure.
Microsystems & Nanoengineering,
Journal Year:
2024,
Volume and Issue:
10(1)
Published: July 17, 2024
Abstract
This
work
presents
the
development
and
design
of
aptasensor
employing
porous
silicon
(PSi)
Fabry‒Pérot
thin
films
that
are
suitable
for
use
as
optical
transducers
detection
lactoferrin
(LF),
which
is
a
protein
biomarker
secreted
at
elevated
levels
during
gastrointestinal
(GI)
inflammatory
disorders
such
bowel
disease
chronic
pancreatitis.
To
overcome
primary
limitation
associated
with
PSi
biosensors—namely,
their
relatively
poor
sensitivity
due
to
issues
related
complex
mass
transfer
phenomena
reaction
kinetics—we
employed
two
strategic
approaches:
First,
we
sought
optimize
nanostructure
respect
factors
including
layer
thickness,
pore
diameter,
capture
probe
density.
Second,
leveraged
convection
properties
by
integrating
resulting
biosensor
into
3D-printed
microfluidic
system
also
had
one
different
micromixer
architectures
(i.e.,
staggered
herringbone
micromixers
or
microimpellers)
embedded.
We
demonstrated
tailoring
significantly
improved
its
performance,
achieving
limit
(LOD)
50
nM—which
>1
order
magnitude
lower
than
achieved
using
previously-developed
biosensors
this
type.
Moreover,
integration
systems
incorporated
passive
active
further
enhanced
aptasensor’s
sensitivity,
an
additional
reduction
in
LOD
yet
another
magnitude.
These
advancements
demonstrate
potential
combining
PSi-based
technology
create
sensitive
label-free
biosensing
platforms
GI
biomarkers.
Biomicrofluidics,
Journal Year:
2023,
Volume and Issue:
17(6)
Published: Dec. 1, 2023
As
one
of
the
hot
spots
in
field
microfluidic
chip
research,
micromixers
have
been
widely
used
chemistry,
biology,
and
medicine
due
to
their
small
size,
fast
response
time,
low
reagent
consumption.
However,
at
Reynolds
numbers,
fluid
motion
relies
mainly
on
diffusive
molecules
under
laminar
flow
conditions.
The
detrimental
effect
leads
difficulties
achieving
rapid
efficient
mixing
fluids
microchannels.
Therefore,
it
is
necessary
enhance
by
employing
some
external
means.
In
this
paper,
classification
principles
passive
(T-type,
Y-type,
obstructed,
serpentine,
three-dimensional)
active
(acoustic,
electric,
pressure,
thermal,
magnetic
field)
are
reviewed
based
presence
or
absence
forces
micromixers,
experiments
applications
each
type
micromixer
briefly
discussed.
Finally,
future
development
trends
summarized.
