Analytical Methods,
Journal Year:
2024,
Volume and Issue:
16(40), P. 6907 - 6915
Published: Jan. 1, 2024
Sugammadex
(SUG)
is
a
novel
antagonist
of
neuromuscular
blocking
agents
(NMBAs).
The
NMBA
rocuronium
usually
employed
to
obtain
better
surgical
conditions
in
kidney
transplant.
Nevertheless,
has
several
disadvantages,
such
as
an
increased
risk
pulmonary
complications.
Thus,
SUG
vital
kidney-transplant
surgery.
However,
because
excreted
by
the
kidneys
prototypes,
pharmacokinetics
(PK)
may
be
affected
patients
with
renal
impairment.
We
developed
liquid
chromatography-tandem
mass
spectrometry
(LC-MS/MS)
method
monitor
plasma
samples
investigate
PK
patients.
Due
complexity
and
limitation
other
methods
sample
preparation,
magnetic
solid-phase
extraction
(MSPE)
was
adopted
purify
samples.
Chromatographic
separation
obtained
using
reversed-phase
Polaris®
C18
column
gradient
elution
0.1%
formic
acid
(FA)
water
phase
A
methanol
(MeOH)
B
mobile
phases.
transitions
999.7
→
963.9
(m/z)
1055.7
1012.2
were
used
quantify
ORG26265,
respectively,
under
negative
electrospray
ionization.
linear
calibration
curve
achieved
concentrations
varying
from
100
10
000
ng
mL-1.
acceptable
accuracy
varied
95.7%
106.4%,
intra-
inter-precision
did
not
exceed
15%
(20%
at
lower
limit
quantitation
(LLOQ)).
matrix
effect,
stability,
dilution
integrity,
carry-over
validated.
This
applied
successfully
for
study
13
recipients
12
donors
transplant
after
intravenous
injection
(2
mL
per
kg
bodyweight).
Journal of Separation Science,
Journal Year:
2025,
Volume and Issue:
48(1)
Published: Jan. 1, 2025
The
most
important
aspect
of
sorbent-based
approaches
is
the
use
a
sustainable,
readily
available,
and
cost-effective
sorbent
material
for
sample
analysis.
Biochar
an
emerging
prominent
various
applications
in
techniques
due
to
its
availability,
affordability,
eco-friendly
nature,
porosity,
pore
structure,
abundance
aliphatic
aromatic
carbon
structures,
abundant
oxygen-containing
functional
groups.
On
basis
numerous
benefits
biochar,
this
review
discusses
why
biochar
preferred
sorptive-based
techniques.
In
addition,
provides
brief
evaluation
biochar-based
sorptive
approaches,
including
solid-phase
extraction
(SPE)/microextraction
(SPME),
magnetic
SPE/SPME,
in-tube
SPME,
pipette-tip
micro
SPE,
thin-film
microextraction.
Furthermore,
each
section
briefly
overviews
studies
analyses
applications,
pharmaceuticals,
environmental,
food.
Most
importantly,
on
literature
review,
that
require
further
investigation
applications.
Foods,
Journal Year:
2024,
Volume and Issue:
13(16), P. 2511 - 2511
Published: Aug. 12, 2024
In
this
study,
a
magnetic
porous
polymer
composite
with
both
hydrophilic
and
hydrophobic
groups
was
synthesized
for
solid
phase
extraction
(MSPE)
of
milk
substrates.
Optimization
conducted
on
various
parameters,
including
adsorption
dose,
solution
pH,
time,
some
elution
conditions.
Coupled
high-performance
liquid
chromatography
fluorescence
detector,
novel
MSPE
method
determination
norfloxacin
(NFX),
ciprofloxacin
(CIP),
enrofloxacin
(ENR)
in
developed
based
metal
organic
framework
polystyrene
(Fe3O4@MOF@PLS)
as
adsorbent.
The
Fe3O4@MOF@PLS
exhibited
significantly
improved
performance
compared
to
MOF
PLS.
Under
optimized
experimental
conditions,
the
good
linearity
three
fluoroquinolones
(FQs)
range
0.5-1000
μg/kg,
limit
detections
(LODs)
ranging
from
0.21
1.33
quantitations
(LOQs)
0.71
4.42
μg/kg.
relative
standard
deviation
(RSD)
FQs
were
3.4-8.8%.
recoveries
samples
ranged
84.2%
106.2%.
This
successfully
applied
detection
20
types
milk,
demonstrating
its
simplicity,
speed,
effectiveness
analyte
enrichment
separation.
presented
advantages
adsorbent
dosage,
LODs,
LOQs,
making
it
valuable
analysis
milk.
