Molecular Mechanisms of Dietary Bioactive Peptides in Treating Alzheimer’s Disease and Mild Cognitive Impairment by Network Pharmacology and Molecular Docking Analysis DOI
Ruirui Li, Jing Zi, Y. Hu

et al.

Rejuvenation Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 13, 2025

Emerging evidence suggests that bioactive peptides from various foods have therapeutic potentials in improving cognitive function Alzheimer's disease (AD) and mild impairment (MCI). We aimed to explore the characteristics of these their mechanisms on AD/MCI using a network pharmacology approach. compiled dataset cognition-enhancing literatures identified shared targets between Swiss Target Predication, PharmMapper, OMIM, GeneCards, TTD, Drugbank databases. then performed functional enrichment analysis constructed gene–gene interaction identify key hub targets. Additionally, we investigated transcription factors (TFs) microRNAs (miRNAs) regulating genes. Molecular docking dynamic simulations were AutoDock Vina GROMACS. 59 oligopeptides, typically short rich arginine. These predicted interact with 222 potential relevant AD/MCI, pathways mainly involving neuroactive ligand-receptor interactions inflammation. 15 targets, regulated by 144 TFs 95 miRNAs. Notably, containing "Trp-Tyr" sequence demonstrated strong binding affinities many especially matrix metalloproteinase-9. The findings provided valuable insights into molecular through which may act against highlight for future exploration natural foods.

Language: Английский

A breakthrough computational strategy for efficient enzymatic digestion of walnut protein to prepare antioxidant peptides DOI
Like Lin, Dan Xiao, Wei Song

et al.

Food Chemistry, Journal Year: 2025, Volume and Issue: 476, P. 143311 - 143311

Published: Feb. 14, 2025

Language: Английский

Citations

0
Molecular Mechanisms of Dietary Bioactive Peptides in Treating Alzheimer’s Disease and Mild Cognitive Impairment by Network Pharmacology and Molecular Docking Analysis DOI
Ruirui Li, Jing Zi, Y. Hu

et al.

Rejuvenation Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 13, 2025

Emerging evidence suggests that bioactive peptides from various foods have therapeutic potentials in improving cognitive function Alzheimer's disease (AD) and mild impairment (MCI). We aimed to explore the characteristics of these their mechanisms on AD/MCI using a network pharmacology approach. compiled dataset cognition-enhancing literatures identified shared targets between Swiss Target Predication, PharmMapper, OMIM, GeneCards, TTD, Drugbank databases. then performed functional enrichment analysis constructed gene–gene interaction identify key hub targets. Additionally, we investigated transcription factors (TFs) microRNAs (miRNAs) regulating genes. Molecular docking dynamic simulations were AutoDock Vina GROMACS. 59 oligopeptides, typically short rich arginine. These predicted interact with 222 potential relevant AD/MCI, pathways mainly involving neuroactive ligand-receptor interactions inflammation. 15 targets, regulated by 144 TFs 95 miRNAs. Notably, containing "Trp-Tyr" sequence demonstrated strong binding affinities many especially matrix metalloproteinase-9. The findings provided valuable insights into molecular through which may act against highlight for future exploration natural foods.

Language: Английский

Citations

0