Precision Imaging of Biothiols in Live Cells and Treatment Evaluation during the Development of Liver Injury via a Near-Infrared Fluorescent Probe
Yinshuang Yang,
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Xiaolan Liu,
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Deyang Xi
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et al.
Chemical & Biomedical Imaging,
Journal Year:
2024,
Volume and Issue:
3(3), P. 169 - 179
Published: Aug. 28, 2024
In
this
study,
a
biothiol-sensitive
near-infrared
(NIR)
fluorescent
sensor,
BDP-CYS,
based
on
coumarin-hemicyanine
skeleton,
was
designed
and
developed
thiol–halogen
SNAr
nucleophilic
substitution.
BDP-CYS
successfully
implemented
to
ratiometrically
monitor
endogenous
exogenous
Cys,
Hcy,
GSH
in
living
cells
as
well
distinguish
between
normal
cancer
cells.
Furthermore,
the
probe
utilized
detect
changes
of
biothiols
drug-induced
hepatotoxicity
evaluate
treatment
effectiveness
diabetes-associated
liver
injury
vivo.
The
advantages
BDP-CYS's
include
practical
sensitivity,
high
selectivity,
rapidity
reaction,
stability
across
range
pH
temperature
conditions,
thus
introducing
new
tool
better
understand
roles
oxidative
stress.
Language: Английский
Near-infrared xanthene fluorescence probe for frequency upconversion fluorescence detection of HSO3− in evaluation of drug-induced hepatotoxicity
Yongquan Wu,
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Shufen Pan,
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Yuting Han
No information about this author
et al.
Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy,
Journal Year:
2024,
Volume and Issue:
329, P. 125519 - 125519
Published: Nov. 30, 2024
Language: Английский