Molecular Selectivity of a pH-Tunable Lecithin-Modified Zirconia Stationary Phase DOI Creative Commons

Yuki Ikuta,

Yuhi Tsubouchi,

Shinji Iwamoto

et al.

ACS Omega, Journal Year: 2024, Volume and Issue: 9(47), P. 46968 - 46973

Published: Nov. 12, 2024

We synthesized lecithin-modified zirconia (LMZ) as an adsorbent, solid-phase extractant, and stationary phase for organic compounds such acids or amino acids. The molecular selectivity of LMZ was evaluated through high-performance liquid chromatography (HPLC). exhibits electrostatic hydrophobic interactions with that depend on the pH mobile phase. Zirconia chosen because its strong affinity phosphate-containing compounds. Soybean lecithin, a model phospholipid, directly stably grafted onto particles Lewis acid–base reaction to form LMZ. presence lecithin surface confirmed solid-state analytical techniques confocal laser scanning microscopy thermogravimetric analysis. assessed by measuring retention behavior aromatic column using HPLC. recognized analyte both effects depended Interestingly, could clearly discriminate between hydrophilic aromatics. specific achieved attributed not only substrate but also ionic alkyl functional groups lecithin.

Language: Английский

Dispersive solid-phase extraction as sample pretreatment for determination of chemotherapeutic agents revumenib and venetoclax by HPLC-DAD DOI
Sergio Fernández-Trujillo, Gregorio Castañeda, Juana Rodrı́guez

et al.

Analytical and Bioanalytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: May 5, 2025

Language: Английский

Citations

0
Molecular Selectivity of a pH-Tunable Lecithin-Modified Zirconia Stationary Phase DOI Creative Commons

Yuki Ikuta,

Yuhi Tsubouchi,

Shinji Iwamoto

et al.

ACS Omega, Journal Year: 2024, Volume and Issue: 9(47), P. 46968 - 46973

Published: Nov. 12, 2024

We synthesized lecithin-modified zirconia (LMZ) as an adsorbent, solid-phase extractant, and stationary phase for organic compounds such acids or amino acids. The molecular selectivity of LMZ was evaluated through high-performance liquid chromatography (HPLC). exhibits electrostatic hydrophobic interactions with that depend on the pH mobile phase. Zirconia chosen because its strong affinity phosphate-containing compounds. Soybean lecithin, a model phospholipid, directly stably grafted onto particles Lewis acid–base reaction to form LMZ. presence lecithin surface confirmed solid-state analytical techniques confocal laser scanning microscopy thermogravimetric analysis. assessed by measuring retention behavior aromatic column using HPLC. recognized analyte both effects depended Interestingly, could clearly discriminate between hydrophilic aromatics. specific achieved attributed not only substrate but also ionic alkyl functional groups lecithin.

Language: Английский

Citations

0