Bioinspired β-Cyclodextrin-Derived Carbon Dots with Emissive and Photothermal Properties as Nanocarriers for Bioactive Agents DOI

Grazia M. L. Consoli,

Ludovica Maugeri, Giuseppe Forte

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 19, 2024

Carbon-based nanostructures are attracting significant interest due to their excellent optical properties, low toxicity, and intriguing applications. Currently, the development of multifunctional carbon-based that integrate supramolecular systems is a challenging topic in advancement biomedical Here, we report an unprecedented example carbon nanodots (Cdots) prepared via one-pot thermal method by heating 2-hydroxypropyl-β-cyclodextrin (HP-βCD) at mild temperature 190 °C. The nanostructured Cdots-HPβCD exhibited green luminescence (ϕPL= 0.02), good photothermal conversion efficiency (η = 33%), strong bioactive agent loading capability. were characterized using spectroscopic techniques atomic force microscopy. formation Cdots-HPβCD/Iodine adducts, iodine release, antimicrobial effect against Staphylococcus aureus Klebsiella pneumoniae strains demonstrated. geometries energy interactions inclusion complex investigated through molecular modeling simulations. versatility as drug nanocontainer was tested entrapping other molecules such curcumin, ciprofloxacin, carvacrol. Finally, cytotoxicity nanocarrier confirmed MTT analysis on Caco2 cell line, interaction with cancer HeLa surface demonstrated evaluation cellular Z potential. binding nanoconstruct albumin steady-state fluorescence. biofriendly combining properties dot core capability cyclodextrin shell appears be promising candidate for multimodal therapy.

Language: Английский

Environmental applications of carbon dots: Addressing microplastics, air and water pollution DOI
Rich Jhon Paul Latiza, Jerry G. Olay, Carlou Eguico

et al.

Journal of Hazardous Materials Advances, Journal Year: 2025, Volume and Issue: 17, P. 100591 - 100591

Published: Jan. 5, 2025

Language: Английский

Citations

3
Enhancing drought tolerance in blackgram (Vigna mungo L. Hepper) through physiological and biochemical modulation by peanut shell carbon dots DOI Creative Commons
K. Abinaya,

Karuppannan Raja,

K. Raja

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 14, 2025

Among the abiotic factors that causes threat to crop production, drought is one of foremost constraints in changing climatic era. Hence, a study was conducted mitigate effect stress blackgram with peanut shell carbon dots (PNS-CDs) as seed priming and foliar spray agent. Blackgram seeds were primed PNS-CDs at 200 ppm for 3 h plants sprayed 50 on 30th 45th DAS under conditions (30%, 50% 75% WHC). The imposed treatments included dry (control), water plants, PNS-CDs, combination both. results demarcate exemplary performance when given combined application (200 ppm) (50 terms its growth yield. Further, an increased activity catalase (12%), peroxidase superoxide dismutase (22%), glutathione reductase (60%), ascorbate (55%), H2O2 scavenging (32%) proline (35%) noticed over seeds, which confirmed antioxidant defense mechanism offered by PNS-CDs. In addition, percentage increase photosynthetic parameters like total chlorophyll (44%), soluble protein (54%), rate (89%), stomatal conductance (40%), internal CO2 concentration (74%) stability index (51%) role photosynthesis enhancer stress, resulted enhanced tolerance, plant Thus, it found followed 30 could serve sustainable alternative chemical inputs, ensuring better productivity tolerance water-limited environments. future research explore molecular mechanisms underlying different crops, biotic will also pave way broader agricultural sustainability eco-friendly approach.

Language: Английский

Citations

0
Green Carbon Dots: Synthesis, Properties, and Theranostic Applications DOI
Sonia Fathi‐karkan, Sina Nasiri,

Maliheh Hasannia

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106861 - 106861

Published: March 1, 2025

Language: Английский

Citations

0
Effect of Cyclodextrins Formulated in Liposomes and Gold and Selenium Nanoparticles on siRNA Stability in Cell Culture Medium DOI Creative Commons

Betzaida Castillo Cruz,

Sandra Chinapen Barletta,

B. Muñoz

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(10), P. 1344 - 1344

Published: Oct. 8, 2024

Encapsulation of siRNA fragments inside liposome vesicles has emerged as an effective method for delivering siRNAs in vitro and vivo. However, the liposome's fluid-phospholipid bilayer liposomes allows to diffuse out liposome, decreasing dose concentration therefore effectiveness carrier. We have previously reported that β-cyclodextrins formulated help increase stability cell culture medium. Here, we continued study include α, γ, methyl-β-cyclodextrins β-cyclodextrin-modified gold selenium nanoparticles.

Language: Английский

Citations

0
Bioinspired β-Cyclodextrin-Derived Carbon Dots with Emissive and Photothermal Properties as Nanocarriers for Bioactive Agents DOI

Grazia M. L. Consoli,

Ludovica Maugeri, Giuseppe Forte

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 19, 2024

Carbon-based nanostructures are attracting significant interest due to their excellent optical properties, low toxicity, and intriguing applications. Currently, the development of multifunctional carbon-based that integrate supramolecular systems is a challenging topic in advancement biomedical Here, we report an unprecedented example carbon nanodots (Cdots) prepared via one-pot thermal method by heating 2-hydroxypropyl-β-cyclodextrin (HP-βCD) at mild temperature 190 °C. The nanostructured Cdots-HPβCD exhibited green luminescence (ϕPL= 0.02), good photothermal conversion efficiency (η = 33%), strong bioactive agent loading capability. were characterized using spectroscopic techniques atomic force microscopy. formation Cdots-HPβCD/Iodine adducts, iodine release, antimicrobial effect against Staphylococcus aureus Klebsiella pneumoniae strains demonstrated. geometries energy interactions inclusion complex investigated through molecular modeling simulations. versatility as drug nanocontainer was tested entrapping other molecules such curcumin, ciprofloxacin, carvacrol. Finally, cytotoxicity nanocarrier confirmed MTT analysis on Caco2 cell line, interaction with cancer HeLa surface demonstrated evaluation cellular Z potential. binding nanoconstruct albumin steady-state fluorescence. biofriendly combining properties dot core capability cyclodextrin shell appears be promising candidate for multimodal therapy.

Language: Английский

Citations

0