Reaching the World Health Organization elimination targets for schistosomiasis: the importance of a One Health perspective

Philosophical Transactions of the Royal Society B Biological Sciences, Journal Year: 2023, Volume and Issue: 378(1887)

Published: Aug. 20, 2023

The past three years has seen the launch of a new World Health Organization (WHO) neglected tropical diseases (NTDs) roadmap, together with revised control and elimination guidelines. Across all, there is now clear emphasis on need to incorporate One approach, recognizing critical links between human animal health environment. Schistosomiasis, caused by Schistosoma spp. trematodes, NTD global medical veterinary importance, over 220 million people untold millions livestock currently infected. Its burden remains extremely high in certain regions, particularly within sub-Saharan Africa, despite two decades mass preventive chemotherapy (mass drug administration), predominantly school-aged children. In contrast Asia, any zoonotic component schistosomiasis transmission its implications for disease has, until recently, been largely ignored. Here, we review recent epidemiological, clinical, molecular, modelling work across both Asia Africa. We outline evolutionary history dynamics species, emphasize emerging risk raised wildlife reservoirs viable hybridization schistosomes. To achieve 2030 WHO roadmap targets, truly multi-disciplinary perspective must be implemented. This article part theme issue ‘Challenges opportunities fight against diseases: decade from London Declaration NTDs’.

Language: Английский

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One Health monitoring reveals invasive freshwater snail species, new records, and undescribed parasite diversity in Zimbabwe

Parasites & Vectors, Journal Year: 2024, Volume and Issue: 17(1)

Published: May 22, 2024

Abstract Background Snail-borne trematodes afflict humans, livestock, and wildlife. Recognizing their zoonotic potential possible hybridization, a One Health approach is essential for effective control. Given the dearth of knowledge on African trematodes, this study aimed to map snail trematode diversity, focusing (i) characterizing gastropod species parasites, (ii) determining infection rates as intermediate hosts medically, veterinary, ecologically significant (iii) comparing diversity across endemic regions. Methods A cross-sectional conducted in 2021 Chiredzi Wedza districts Zimbabwe, known high human schistosomiasis prevalence, involved malacological surveys at 56 sites. Trematode infections snails were detected through shedding experiments multiplex rapid diagnostic polymerase chain reactions (RD-PCRs). Morphological molecular analyses employed identify species. Results Among 3209 collected specimens, 11 identified, including schistosome fasciolid competent We report first time invasive exotic Tarebia granifera which was highly abundant, mainly Chiredzi, occurring 29 out 35 Shedding 1303 revealed 2.24% rate, with 15 identified genotyping. Five exclusive Chiredzi: Bolbophorus sp., Schistosoma mansoni , mattheei, Calicophoron Uvulifer sp. Eight Wedza, Trichobilharzia Stephanoprora amurensis Spirorchid Echinostoma well an unidentified Plagiorchioidea superfamily. species, Tylodelphys mashonensis common both The RD-PCR screening 976 non-shedding indicated 35.7% presence schistosomes (1.1%) Fasciola nyanzae (0.6%). In Radix natalensis had highest prevalence (33.3%), while R. (55.4%) Bulinus tropicus (53.2%) prevalence. Conclusions Our xenomonitoring unveiled nine new records Zimbabwe. persists region despite six mass deworming rounds. parasite that can impact biomedically important underscores need increased monitoring. Graphical

Language: Английский

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Prevention and control of schistosomiasis in the Philippines from a health education perspective

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13

Published: April 9, 2025

Schistosomiasis, second only to malaria, poses a significant threat many regions worldwide, particularly tropical and subtropical areas. The Philippines, located in region, has long suffered from the serious public health hazards of schistosomiasis. We recognize that, besides direct snail control mass drug administration, education plays crucial role, either directly or indirectly, prevention Therefore, this paper delves into current status schistosomiasis evolving strategies for control, significance these efforts, with particular focus on analyzing impact, achievements, challenges educational interventions control. This detailed analysis aims provide comprehensive perspective overall progress Philippines.

Language: Английский

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Vitamin K2 - Vital for Health and Wellbeing

InTech eBooks, Journal Year: 2017, Volume and Issue: unknown

Published: March 22, 2017

This book serves as a comprehensive survey of the impact vitamin K2 on cellular functions and organ systems, indicating that plays an important role in differentiation/preservation various cell phenotypes stimulator and/or mediator interorgan cross talk. Vitamin binds to transcription factor SXR/PXR, thus acting like hormone (very much same manner A D). Therefore, affects multitude it is reckoned be one positive bringing about "longevity" human body, e.g., supporting functions/health different well correcting functioning or even "curing" ailments striking several organs our body.
- Vital for Health Wellbeing has been produced distributed through support from Kappa Bioscience, Norway.

Language: Английский

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Vertebral Plasma Cell Tumors in 8 Dogs

Journal of Veterinary Internal Medicine, Journal Year: 1999, Volume and Issue: 13(2), P. 126 - 126

Published: Jan. 1, 1999

The case histories of 8 dogs with spinal pain and neurologic deficits associated vertebral plasma cell tumor are reviewed. Four had solitary plasmacytoma, 3 multiple myeloma, 1 dog 2 lesions no evidence disseminated disease. were treated: myeloma received chemotherapy only survived 17 26 months, respectively. Two plasmacytomas the spine radiotherapy: 1st 4 months was euthanized after developing radiation myelopathy; 2nd 65 before myeloma. diagnosis plasmacytoma versus is discussed.

Language: Английский

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Chylomicron remnants and oxidised low density lipoprotein have differential effects on the expression of mRNA for genes involved in human macrophage foam cell formation

Journal of Molecular Medicine, Journal Year: 2004, Volume and Issue: 82(7)

Published: May 19, 2004

Language: Английский

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Necrotising fasciitis with sub-periosteal Streptococcus canis infection in two puppies

Veterinary and Comparative Orthopaedics and Traumatology, Journal Year: 2008, Volume and Issue: 21(05), P. 474 - 477

Published: Jan. 1, 2008

Summary Necrotising fasciitis is an uncommon and potentially devastating disease which has been infrequently reported in animals. This brief communication describes unusual presentation of necrotising two immature Bull Terriers. Both animals were admitted with a history minimal trauma yet rapidly progressive, localising, disproportionate pain. Streptococcus canis was cultured from sub-periosteal fluid-filled pockets surrounding the femur both cases.

Language: Английский

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Population genetics and molecular xenomonitoring of Biomphalaria freshwater snails along the southern shoreline of Lake Malawi, Malawi

Parasites & Vectors, Journal Year: 2024, Volume and Issue: 17(1)

Published: Dec. 18, 2024

Abstract Background Intestinal schistosomiasis was confirmed endemic in Mangochi District, Malawi, May of 2018 following an unexpected encounter with discreet populations Biomphalaria spp. freshwater snails during routine malacological surveillance activities. Since then, only limited has been carried out, and so the distribution this area is currently unclear. Additionally, sites active Schistosoma mansoni transmission are also unknown. In present study, through extensive surveillance, we aimed to formally document District. We identify intestinal subjecting all collected a recently developed S. mansoni- specific molecular xenomonitoring PCR. Methods Three surveys were out along southern shoreline Lake November 2021, July 2022 October/November 2022. All subjected cercarial shedding analysis infections. Shed cercariae then genotyped species level using standard multi-locus PCR Sanger sequencing protocol. Following this, subset from each collection site infected, but non-shedding, Biomphalaria. Results A total 589 across three surveys. One single (0.17%) specimen found be actively cercariae, which molecularly as . ( n = 42) identified B. pfeifferi further 19 specimens, four different sites, infected xenomonitoring. therefore at foci Conclusions Our study highlights importance approaches investigate monitor -associated areas. As such, continued development use such approaches, particular assays that can resource-poor schistosomiasis-endemic settings, encouraged. The revision ongoing control programmes line WHO recommendations, Graphical abstract

Language: Английский

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Requirement for ERK1/2 Activation in the Regulation of Progesterone Production in Human Granulosa-Lutein Cells Is Stimulus Specific

Endocrinology, Journal Year: 2002, Volume and Issue: 143(3), P. 877 - 888

Published: March 1, 2002

The past three years has seen the launch of a new World Health Organization (WHO) neglected tropical diseases (NTDs) roadmap, together with revised control and elimination guidelines.Across all, there is now clear emphasis on need to incorporate One approach, recognizing critical links between human animal health environment.Schistosomiasis, caused by Schistosoma spp.trematodes, NTD global medical veterinary importance, over 220 million people untold millions livestock currently infected.Its burden remains extremely high in certain regions, particularly within sub-Saharan Africa, despite two decades mass preventive chemotherapy (mass drug administration), predominantly school-aged children.In contrast Asia, any zoonotic component schistosomiasis transmission its implications for disease has, until recently, been largely ignored.Here, we review recent epidemiological, clinical, molecular, modelling work across both Asia Africa.We outline evolutionary history dynamics species, emphasize emerging risk raised wildlife reservoirs viable hybridization schistosomes.To achieve 2030 WHO roadmap targets, truly multi-disciplinary perspective must be implemented.This article part theme issue 'Challenges opportunities fight against diseases: decade from London Declaration NTDs'.

Language: Английский

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Trend of Human Schistosomiasis Japonica Prevalence in China from 1990 to 2019

Tropical Medicine and Infectious Disease, Journal Year: 2023, Volume and Issue: 8(7), P. 344 - 344

Published: June 29, 2023

Schistosomiasis (Schistosomiasis japonica) remains an important public health problem in China, and the Chinese government has set ambitious goal of eliminating schistosomiasis by 2030. Based on observational study Global Burden Disease Study database 2019 (GBD2019) World Bank database, this aimed to analyze prevalence trend China from 1990 using joinpoint regression model, relationship between economic social development prevalence. The data age-standardized infection rates (ASRs) Health Data Exchange were collected, Gross national product per capita (GDP) people safely managed sanitation services ((PPMS) % population) extracted database. Trends ASR analyzed analysis, association with GDP, PPMS Pearson correlation analysis. results reveal that, 2019, overall showed a decrease for both sexes, decreases men relatively smaller compared women. A larger been observed age groups 15 49 years other groups. had significant negative GDP PPMS. This identified decreasing rate since 1990. Continuous investment, optimization control strategy, will help achieve elimination.

Language: Английский

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