Polymer Grafting to Polydopamine Free Radicals for Universal Surface Functionalization

Journal of the American Chemical Society, Journal Year: 2022, Volume and Issue: 144(15), P. 6992 - 7000

Published: April 11, 2022

Modifying surfaces using free radical polymerization (FRP) offers a means to incorporate the diverse physicochemical properties of vinyl polymers onto new materials. Here, we harness universal surface attachment polydopamine (PDA) "prime" range different for polymer attachment, including glass, cotton, paper, sponge, and stainless steel. We show that intrinsic species present in PDA can serve as an anchor point subsequent propagating macroradicals through radical–radical coupling. Leveraging straightforward, twofold soak-wash protocol, FRP over PDA-functionalized results covalent on both porous nonporous substrates, imparting functionalized materials, enhanced hydrophobicity, fluorescence, or temperature responsiveness. Our strategy is then extended covalently nanoparticles into organo-/hydrogels via cross-linking, yielding tunable PDA–polymer composite networks. The propensity radicals quench studied situ 1H nuclear magnetic resonance electron paramagnetic spectroscopy, revealing area-dependent macroradical scavenging mechanism underpins conjugation. By combining arbitrary with broad polymers, our provides straightforward route unlimited functionality practically any surface.

Language: Английский

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Melanin-like polydopamine nanoparticles mediating anti-inflammatory and rescuing synaptic loss for inflammatory depression therapy

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: Feb. 10, 2023

Inflammatory depression is closely related to neuroinflammation. However, current anti-inflammatory drugs have low permeability cross blood-brain barrier with difficulties reaching the central nervous system provide therapeutic effectiveness. To overcome this limitation, nano-based drug delivery technology was used synthesize melanin-like polydopamine nanoparticles (PDA NPs) (~ 250 nm) which can barrier. Importantly, PDA NPs abundant phenolic hydroxyl groups function as excellent free radical scavengers attenuate cell damage caused by reactive oxygen species or acute inflammation. In vitro experiments revealed that exhibited antioxidative properties. Next, we aimed investigate effect of on inflammatory through intraperitoneal injection lipopolysaccharide-induced model in mice. significantly reversed depression-like behavior. also found reduce peripheral and inflammation induced LPS, showing alleviated splenomegaly, reduced serum cytokines, inhibited microglial activation restored synaptic loss. Various showed had good biocompatibility both vivo vitro. Our work suggested may be biocompatible nano-drugs treating but their clinical application requires further study.

Language: Английский

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Chitosan-based antibacterial microspheres loaded multifunctional Janus composite membranes with unidirectional biofluid transport, antioxidant and pH-responsive monitoring

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 472, P. 144820 - 144820

Published: July 17, 2023

Language: Английский

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Nanomodulators Capable of Timely Scavenging ROS for Inflammation and Prognosis Control Following Photothermal Tumor Therapy

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(21)

Published: March 14, 2023

Abstract Despite the accuracy advantages of photothermal therapy (PTT), heat stress‐initiated free radicals and damage‐activated immune cells form a malignant positive feedback cycle following light irradiation. Herein, 2D allomelanin nanomodulator with perpendicularly oriented oligomer planes is prepared by guidance DNA to achieve timely scavenging reactive oxygen species (ROS) for inflammation prognosis control PTT. A large exposure degree phenol groups effective transfer delocalized electrons result in ultra‐fast redox reactions that can be boosted self‐amplifying process through structure disintegration. Compared conventional agents, nanodisks reduce accumulation ROS during PTT 25‐fold, downregulate proinflammatory factors, adjust levels baseline. Thereby, successful modulation M2‐type macrophages paratumor tissues significantly prevents burn wound progression accelerates tissue repair, while well‐controlled neutrophil extracellular traps largely recruited CD4 + /CD8 T (1.6–3.2‐fold) ablation site suppress relapse distant tumors. The study provides useful inspiration on rationally modulating active nanostructures address issues

Language: Английский

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An antibacterial membrane based on Janus bacterial cellulose with nano-sized copper oxide through polydopamine conjugation for infectious wound healing

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 332, P. 121923 - 121923

Published: Feb. 6, 2024

Language: Английский

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