Dual-Targeted Metal Ion Network Hydrogel Scaffold for Promoting the Integrated Repair of Tendon–Bone Interfaces

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(5), P. 5582 - 5597

Published: Jan. 23, 2024

The tendon-bone interface has a complex gradient structure vital for stress transmission and pressure buffering during movement. However, injury to the tissue, especially tendon cartilage components, often hinders complete restoration of original structure. Here, metal ion network hydrogel scaffold, with capability targeting multitissue, was constructed through photopolymerization LHERHLNNN peptide-modified zeolitic imidazolate framework-8 (LZIF-8) WYRGRL magnesium metal-organic framework (WMg-MOF) within which could facilitate directional migration ions form dynamic gradient, thereby achieving integrated regeneration tissues. LZIF-8 selectively migrated tendon, releasing zinc enhance collagen secretion promoting repair. Simultaneously, WMg-MOF cartilage, induce cell differentiation facilitating regeneration. Infrared spectroscopy confirmed successful peptide modification nano ZIF-8 Mg-MOF. Fluorescence imaging validated that LZIF-8/WMg-MOF had longer retention, indirectly confirming their interface. In summary, this dual-targeted scaffold potential synchronized multitissue at compromised interface, offering favorable prospects its application in reconstruction characterized by

Language: Английский

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Wet environment-induced adhesion and softening of coenzyme-based polymer elastic patch for treating periodontitis

Bioactive Materials, Journal Year: 2024, Volume and Issue: 35, P. 259 - 273

Published: Feb. 7, 2024

Periodontitis, a common chronic inflammatory disease caused by pathogenic bacteria, can be treated with diverse biomaterials loading drugs, cytokines or proteins. However, these often show unsatisfactory therapeutic efficiency due to their poor adhesion, short residence time in the wet and dynamic oral cavity emerging drug resistance. Here we report wet-responsive methacrylated gelatin (GelMA)-stabilized co-enzyme polymer poly(α-lipoic acid) (PolyLA)-based elastic patch water-induced adhesion softening features. In PolyLA-GelMA, multiple covalent hydrogen-bonding crosslinking between PolyLA GelMA prevent depolymerization slow down dissociation of water, allowing durable periodontal tissue continuous release LA-based bioactive small molecule periodontitis wound without resorting external drugs. Compared undifferentiated behavior traditional adhesives, this demonstrates favorable pocket insertion ability its non-adhesion rigidity dry environment. vitro studies reveal that PolyLA-GelMA exhibits satisfactory antibacterial, blood compatibility ROS scavenging abilities. model rat periodontitis, inhibits alveolar bone resorption accelerates healing regulating microenvironment. This biomacromolecule-stabilized coenzyme provides new option promote treatment.

Language: Английский

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Multifunctionalized and Dual‐Crosslinked Hydrogel Promotes Inflammation Resolution and Bone Regeneration via NLRP3 Inhibition in Periodontitis

Small Structures, Journal Year: 2024, Volume and Issue: 5(3)

Published: Feb. 5, 2024

Alveolar bone resorption caused by bacteria‐induced periodontitis remains challenging due to sustained inflammation. Periodontal pathogens like Porphyromonas gingivalis launch the primed signal of NOD‐like receptor family pyrin domain‐containing 3 (NLRP3) inflammasome in macrophages; consequent overproduction proinflammatory cytokines and reactive oxygen species (ROS) leads tissue destruction. This provides potential targets for a new therapeutic strategy. Herein, multifunctionalized dual‐crosslinked hydrogel pGM/cPL@NI with NLRP3 inhibitor MCC950 loaded is prepared. Driven strategic functionalization gelatin methacryloyl ε ‐poly‐lysine phenylboronic acid catechol, respectively, containing dynamic photo‐crosslinking networks demonstrates superior mechanical strength stimuli‐responsive behavior, as well overwhelmed performance bacteria killing ROS scavenging. Crucially, restores compromised osteogenesis specifically suppressing cytokine cascade triggered activation promoting anti‐inflammatory polarization macrophages. Collectively, presents robust an effective “cocktail therapy” combining antibacterial, antioxidant, inflammation resolution, regenerative functions. The present study reveals underlying mechanism bacterial‐immune‐regeneration extended approach periodontal engineering.

Language: Английский

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Injectable Nanocomposite Hydrogels with Strong Antibacterial, Osteoinductive, and ROS-Scavenging Capabilities for Periodontitis Treatment

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(12), P. 14421 - 14433

Published: March 18, 2024

Injectable antibacterial and osteoinductive hydrogels have received considerable attention for promoting bone regeneration owing to their versatile functionalities. However, a current hydrogel with antibacterial, osteoinductive, antioxidant properties by facile method periodontitis treatment is still missing. To overcome this issue, we designed an injectable system (GPM) composed of gelatin, Ti3C2Tx MXene nanosheets, poly-l-lysine using simple enzymatic cross-linking technique. Physicochemical characterization demonstrated that the GPM matrix exhibited excellent stability, moderate tissue adhesion ability, good mechanical behavior. The significantly inhibited growth Porphyromonas gingivalis, scavenged reactive oxygen species, attenuated inflammatory responses, enhanced regeneration. Intriguingly, arrangement junctional epithelium, alveolar volume, height in GPM-treated periodontal disease group recovered healthy group. Therefore, our functions may serve as scaffold periodontitis.

Language: Английский

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Supra-alveolar bone regeneration: Progress, challenges, and future perspectives

Composites Part B Engineering, Journal Year: 2024, Volume and Issue: 283, P. 111673 - 111673

Published: July 3, 2024

Language: Английский

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