Journal of Materials Chemistry B,
Journal Year:
2022,
Volume and Issue:
11(5), P. 1090 - 1099
Published: Dec. 12, 2022
Different
from
common
anti-tumor
drugs,
organoplatinum(II)
metallacycles
can
integrate
imaging
and
other
therapeutic
capabilities
by
incorporating
corresponding
functional
donor
ligands
to
enable
potential
applications
in
biomedicine.
However,
most
of
the
emerging
agents
not
only
show
poor
solubility
selectivity
but
also
have
serious
side
effects
unsatisfactory
efficacy
encounter
tendency
develop
drug
resistance
due
their
single
treatment
model.
Herein,
an
metallacycle
(PtM)
was
designed
synthesized
using
coordination-driven
self-assembly
via
combination
a
metallic
chemotherapy
precursor
reactive
oxygen
species
generating
organic
precursor.
The
hydrophobic
PtM
molecules
were
encapsulated
cavity
human
heavy
chain
ferritin
(HFn)
during
reassembly
HFn
prepare
active
targeting
nanoagent
HFn-PtM
for
use
chemo-photodynamic
therapy.
nanoagents
exhibited
excellent
stability
buffer
(pH
5
7.2),
alleviating
concern
leakage
circulation.
A
cellular
uptake
assay
indicated
that
could
efficiently
enter
specific
cells
overexpress
transferrin
receptor
1.
In
vitro
vivo
investigations
revealed
efficiency
with
negligible
systemic
toxicity.
This
work
provides
strategy
easy
construction
multifunctional
organoplatinum-based
tumor-targeted
drugs.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(35), P. 23827 - 23841
Published: Aug. 20, 2024
Carrier-free
nanodrugs
with
extraordinary
active
pharmaceutical
ingredient
(API)
loading
(even
100%),
avoidable
carrier-induced
toxicity,
and
simple
synthetic
procedures
are
considered
as
one
of
the
most
promising
candidates
for
disease
theranostics.
Substantial
studies
commercial
success
"carrier-free"
nanocrystals
have
demonstrated
their
strong
clinical
potential.
However,
practical
translations
remain
challenging
impeded
by
unpredictable
assembly
processes,
insufficient
delivery
efficiency,
an
unclear
in
vivo
fate.
In
this
Perspective,
we
systematically
outline
contemporary
emerging
carrier-free
based
on
diverse
APIs,
well
highlight
opportunities
challenges
translation.
Looking
ahead,
further
improvements
design
preparation,
drug
delivery,
efficacy,
safety
nanomedicines
essential
to
facilitate
translation
from
bench
bedside.
Materials Today Bio,
Journal Year:
2023,
Volume and Issue:
18, P. 100542 - 100542
Published: Jan. 4, 2023
Chemo-photodynamic
therapy
shows
great
potential
for
cancer
treatment.
However,
the
rational
integration
of
chemotherapeutic
agents
and
photosensitizers
to
construct
an
intelligent
nanoplatform
with
synergistic
therapeutic
effect
is
still
a
challenge.
In
this
work,
curcumin-loaded
reduction-responsive
prodrug
nanoparticles
new
indocyanine
green
([email
protected])
were
developed
chemo-photodynamic
therapy.
[email
protected]
exhibit
high
drug
loading
content
special
worm-like
morphology,
contributing
their
efficient
cellular
uptake.
Due
presence
disulfide
bond
between
IR820
PEG,
display
reduction
responsive
release
behaviors.
The
uptake
triggered
lead
enhanced
in
vitro
cytotoxicity
against
4T1cells
as
compared
mixture
curcumin
(IR820/Cur)
under
laser
irradiation.
Besides,
prolonged
blood
half-life
time,
better
tumor
accumulation
retention,
hypoxia-inducible
factor-1α
(HIF-1α)
vascular
endothelial
cell
growth
factor
(VEGF)
suppression
IR820/Cur.
vivo
antitumor
activity
study,
effectively
inhibit
angiogenesis,
which
potentiates
PDT
efficacy
leads
best
This
work
provides
novel
relatively
simple
strategy
Molecules,
Journal Year:
2023,
Volume and Issue:
28(20), P. 7065 - 7065
Published: Oct. 13, 2023
Nanocarriers
have
been
widely
studied
and
applied
in
the
field
of
cancer
treatment.
However,
conventional
nanocarriers
still
suffer
from
complicated
preparation
processes,
low
drug
loading,
potential
toxicity
carriers
themselves.
To
tackle
hindrance,
carrier-free
nanodrugs
with
biological
activity
received
increasing
attention
therapy.
Extensive
efforts
made
to
exploit
new
self-assembly
methods
mechanisms
expand
scope
enhanced
therapeutic
performance.
In
this
review,
we
summarize
advanced
progress
applications
based
on
different
types
assembly
strategies,
which
involved
noncovalent
interactions,
a
combination
covalent
bonds
metal
ions-coordinated
self-assembly.
These
are
introduced
detail
according
their
antitumor
applications.
Finally,
prospects
existing
challenges
future
development
clinical
application
discussed.
We
hope
that
comprehensive
review
will
provide
insights
into
rational
design
more
effective
nanodrug
systems
advancing
other
diseases
(e.g.,
bacterial
infections)
infection
Research Square (Research Square),
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 28, 2025
Abstract
Although
immune
checkpoint
blockade
(ICB)
therapies
have
shown
clinical
benefit,
ICB
remains
limited
effect
on
most
“immune-cold”
solid
tumors,
i.e.,
tumors
with
low
infiltration.
Near-infrared
photoimmunotherapy
(NIR-PIT)
converts
“cold”
into
“hot”
thereby
enhancing
responses
and
improving
efficacy.
Hence,
developing
a
strategy
that
can
integrate
NIR-PIT
treatment
is
desirable.
In
this
study,
we
designed
unique
carrier-free
PSP@IR-CF3
nanofiber
(NF),
self-assembled
from
the
PD-L1
targeting
immune-peptide
NTGYFYGDQ
(PSP)
agents
(IR-CF3).
The
NFs
enable
precise
tumor
inhibition
by
specifically
binding
to
cell
surface,
also
providing
an
NIR-mediated
photothermal
effect.
Applying
NIR
induced
mild
NIR-PIT,
which
effectively
activated
microenvironment
treat
lower
immunotoxicity.
Moreover,
identified
HSP70/AKT/mTOR
signaling
pathway,
regulates
resistance
recurrence,
was
after
PIT.
By
incorporating
mTOR
inhibitors
like
rapamycin,
combination
reduce
decrease
significantly
therapeutic
outcomes.
This
innovative
therapy
has
potential
revolutionize
offering
more
interventions
markedly
enhance
immunotherapeutic
efficacy,
toxicity,
improve
patient
ACS Applied Nano Materials,
Journal Year:
2024,
Volume and Issue:
7(5), P. 5628 - 5636
Published: Feb. 22, 2024
The
theophylline
derivative
d17
is
a
candidate
drug
for
nonsmall
cell
lung
cancer
(NSCLC)
treatment
previously
developed
by
our
group.
However,
it
has
the
limitations
of
inadequate
bioavailability,
poor
targeting,
and
insignificant
therapeutic
effect.
Chemo-photodynamic
synergistic
therapy
promising
method
antitumor
therapy.
Herein,
photosensitizer
chlorin
e6
(Ce6)
were
loaded
into
nanoparticles
(NPs)
via
supramolecular
self-assembly,
which
are
self-assembled
through
π–π
stacking
hydrogen
bond
interactions
to
form
nanospheres
with
size
about
85
nm
surface
charge
−33
mV.
Compared
free
Ce6,
d17–Ce6
NPs
have
good
hydrophilicity
stability
can
effectively
accumulate
in
NSCLC
tumor
tissues
due
enhancement
retention
More
significantly,
synergistically
inhibit
growth
compared
other
groups
no
obvious
toxicity.
Taken
together,
may
be
an
effective
carrier-free
nanodrug
chemo-photodynamic
NSCLC.
