Traditional Chinese Medicine-Based Nanoformulations for Enhanced Photothermal Therapy of Cancer

ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Photothermal therapy (PTT) has shown promise in the ablation of small, unresectable tumors by boosting tumor's temperature above 50 °C. However, high local temperature-induced cancer cell necrosis could create severe inflammation, which may deteriorate normal tissues and increase tumor spreading. Although mild photothermal (MPTT) at 42-45 °C avoid undesired side effect to some extent with minimal nonspecific heat diffusion, self-protective behavior during MPTT results an unsatisfactory therapeutic effect. Inspired widespread applications traditional Chinese medicine (TCM) various ailments, we also extensively explored use TCM PTT MPTT. In this Review, summarize application function MPTT, including following: (1) improves performance elevating conversion ability agents (PTAs) overcoming tumors, (2) enhances TCM-based chemotherapy improving sensitivity cellular uptake (3) natural metal-chelated nanoparticles directly act as PTAs for carrier-free combination therapy. We expect Review will further illuminate TCM's utility applicability treatment new strategies theragnostic use.

Language: Английский

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Luteolin-Manganese Nanozyme Induces Apoptosis and Ferroptosis for Enhanced Cancer Therapy

Inorganic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Cancer presents a significant global public health challenge that impacts millions of individuals worldwide. The incorporation natural products into cancer treatment has the potential to mitigate many side effects commonly associated with chemotherapy. This study builds on advantages enhancing anticancer activity flavonoids through metal chelation by synthesizing antioxidant flavonoid complex, termed Lu-Mn nanozyme, which involves luteolin manganese ions. In vitro experiments demonstrated exhibits strong affinity for hydrogen peroxide (H2O2) and effectively catalyzes generation hydroxyl radicals (•OH) from H2O2 within tumor microenvironment. administration nanozyme not only induced apoptosis in cells upregulating expression cleaved caspase3 caspase9 but also activated ferroptosis downregulation NRF2-GPX4 signaling pathway. Furthermore, animal studies have shown possesses antitumor efficacy favorable safety profile. Collectively, these findings suggest luteolin, its ions, considerable application treatment.

Language: Английский

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Herb‐Metal Ion Coordination Compounds with Photo/Electromagnetic Wave Response for Developing Various Anti‐Infection Strategies

Small, Journal Year: 2025, Volume and Issue: unknown

Published: March 23, 2025

Abstract The global rise in infectious diseases and antibiotic overuse exacerbate bacterial drug resistance, particularly multidrug‐resistant pathogens like methicillin‐resistant Staphylococcus aureus (MRSA). While plant‐derived flavones exhibit multi‐target antibacterial mechanisms that overcome their therapeutic application remains constrained by poor aqueous dispersibility stability. Herein, a luteolin‐iron complex (Lut‐Fe 3 ⁺) is engineered through facile coordination approach, where Fe ⁺ facilitates d ‐orbital splitting generation of high‐spin electrons. This octahedral demonstrates exceptional water exhibits broad‐spectrum absorption across ultraviolet to microwave (MW) frequencies. Lut‐Fe dual antimicrobial modalities: long‐term antisepsis the dark rapid sterilization under light/MW irradiation. multi‐functional further combined with various methods develop strategies for infections at different depths. Notably, into an MW‐responsive nebulization system, achieving effective eradication MRSA‐induced deep‐tissue pneumonia mice.

Language: Английский

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Dual-modality immune nano-activator harnessing Mn2⁺ and quercetin to potentiate the cGAS-STING pathway for advanced cancer metalloimmunotherapy

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 25, 2025

Manganese ions (Mn2+) have emerged as promising activators of the cyclic GMP-AMP synthase-stimulator interferon genes (cGAS-STING) pathway. However, their clinical application was hindered by low bioavailability and limited immune activation pathways, which impaired ability to trigger robust responses achieve significant antitumor effects. To address these challenges, we developed a dual-modality nano-activator coordinating manganese with quercetin. This strategy designed enhance cGAS-STING pathway elicit immunogenic cell death, thereby strengthening response. The engineered demonstrated superior tumor-targeting efficient cellular internalization. Upon exposure near-infrared irradiation, system harnessed photothermal effects induce apoptosis in tumor cells while simultaneously accelerating release released facilitated generation reactive oxygen species, conjunction quercetin-induced apoptosis, amplified photothermal-induced DNA damage. damage further promoted cytosolic DNA, turn activated pathway, intensifying activation. Notably, also triggered synergized promote dendritic maturation activate antigen-specific T-cell, significantly enhancing response against tumor. Both vitro vivo studies confirmed that this effectively inhibited growth, particularly pronounced when combined anti-CTLA-4 antibodies.

Language: Английский

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Multidimensional profiling of functionalized photothermal nanoplatforms for synergistic cancer immunotherapy: Design, strategy, and challenge

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 499, P. 215488 - 215488

Published: Oct. 26, 2023

Language: Английский

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