Interactive Journal of Medical Research,
Journal Year:
2025,
Volume and Issue:
14, P. e66286 - e66286
Published: Feb. 26, 2025
Background
Ferroptosis,
as
a
novel
modality
of
cell
death,
holds
significant
potential
in
elucidating
the
pathogenesis
and
advancing
therapeutic
strategies
for
breast
cancer.
Objective
This
study
aims
to
comprehensively
analyze
current
ferroptosis
research
future
trends,
guiding
cancer
advancements
innovative
treatment
strategies.
Methods
used
R
package
Bibliometrix
(Department
Economic
Statistical
Sciences
at
University
Naples
Federico
II),
VOSviewer
(Centre
Science
Technology
Studies
Leiden
University),
CiteSpace
(Drexel
University’s
College
Information
Technology),
conduct
bibliometric
analysis
387
papers
on
from
Web
Core
Collection.
The
covers
authors,
institutions,
journals,
countries
or
regions,
publication
volumes,
citations,
keywords.
Results
number
publications
related
this
field
has
surged
annually,
with
China
United
States
collaborating
closely
leading
output.
Sun
Yat-sen
stands
out
among
while
journal
Frontiers
Oncology
author
Efferth
T
contribute
significantly
field.
Highly
cited
within
domain
primarily
focus
induction
ferroptosis,
protein
regulation,
comparisons
other
modes
providing
foundation
treatment.
Keyword
highlights
maturity
glutathione
peroxidase
4-related
research,
subtypes
emerging
motor
themes
tumor
microenvironment,
immunotherapy,
prognostic
models
identified
basic
themes.
Furthermore,
application
nanoparticles
serves
an
additional
complement
Conclusions
status
focuses
exploration
relevant
theoretical
mechanisms,
whereas
trends
mechanisms
emphasize
investigation
strategies,
particularly
clinical
immunotherapy
microenvironment.
Nanotherapy
demonstrated
domain.
Future
directions
should
deepen
accelerate
translation
findings
provide
new
insights
innovation
development
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
15
Published: Jan. 10, 2025
Breast
cancer
is
the
most
commonly
diagnosed
worldwide.
Metal
metabolism
pivotal
for
regulating
cell
fate
and
drug
sensitivity
in
breast
cancer.
Iron
copper
are
essential
metal
ions
critical
maintaining
cellular
function.
The
accumulation
of
iron
triggers
distinct
death
pathways,
known
as
ferroptosis
cuproptosis,
respectively.
Ferroptosis
characterized
by
iron-dependent
lipid
peroxidation,
while
cuproptosis
involves
copper-induced
oxidative
stress.
They
increasingly
recognized
promising
targets
development
anticancer
drugs.
Recently,
compelling
evidence
demonstrated
that
interplay
between
plays
a
crucial
role
progression.
This
review
elucidates
converging
pathways
Moreover,
we
examined
value
genes
associated
with
clinical
diagnosis
treatment
cancer,
mainly
outlining
potential
co-targeting
approach.
Lastly,
delve
into
current
challenges
limitations
this
strategy.
In
general,
offers
an
overview
interaction
offering
valuable
perspectives
further
research
treatment.
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
15
Published: Jan. 15, 2025
Triple-negative
breast
cancer
(TNBC)
is
a
type
of
with
lack
the
expression
estrogen
receptor
(ER),
progesterone
(PR),
and
human
epidermal
growth
factor
2
(HER2).
It
most
aggressive
difficult
to
treat
due
its
poor
response
treatments
extremely
invasive
characteristics.
The
typical
treatment
for
TNBC
frequently
results
in
relapse
because
particular
choices.
urgent
focus
on
identifying
workable
effective
target
TNBC.
Cancer
metastasis
significantly
influenced
by
epithelial-mesenchymal
transition
(EMT).
Ferroptosis
an
iron-dependent
cell
death
form,
changes
key
affect
proliferation
Several
reports
have
established
associations
between
EMT
ferroptosis
metastasis.
Furthermore,
non-coding
RNA
(ncRNA),
which
has
been
previously
described,
can
also
control
Thus,
this
review,
we
summarize
correlation
pathways
among
ferroptosis,
EMT,
ncRNAs
Also,
aim
find
out
novel
strategy
through
ncRNA-ferroptosis-EMT
axis.
Interactive Journal of Medical Research,
Journal Year:
2025,
Volume and Issue:
14, P. e66286 - e66286
Published: Feb. 26, 2025
Background
Ferroptosis,
as
a
novel
modality
of
cell
death,
holds
significant
potential
in
elucidating
the
pathogenesis
and
advancing
therapeutic
strategies
for
breast
cancer.
Objective
This
study
aims
to
comprehensively
analyze
current
ferroptosis
research
future
trends,
guiding
cancer
advancements
innovative
treatment
strategies.
Methods
used
R
package
Bibliometrix
(Department
Economic
Statistical
Sciences
at
University
Naples
Federico
II),
VOSviewer
(Centre
Science
Technology
Studies
Leiden
University),
CiteSpace
(Drexel
University’s
College
Information
Technology),
conduct
bibliometric
analysis
387
papers
on
from
Web
Core
Collection.
The
covers
authors,
institutions,
journals,
countries
or
regions,
publication
volumes,
citations,
keywords.
Results
number
publications
related
this
field
has
surged
annually,
with
China
United
States
collaborating
closely
leading
output.
Sun
Yat-sen
stands
out
among
while
journal
Frontiers
Oncology
author
Efferth
T
contribute
significantly
field.
Highly
cited
within
domain
primarily
focus
induction
ferroptosis,
protein
regulation,
comparisons
other
modes
providing
foundation
treatment.
Keyword
highlights
maturity
glutathione
peroxidase
4-related
research,
subtypes
emerging
motor
themes
tumor
microenvironment,
immunotherapy,
prognostic
models
identified
basic
themes.
Furthermore,
application
nanoparticles
serves
an
additional
complement
Conclusions
status
focuses
exploration
relevant
theoretical
mechanisms,
whereas
trends
mechanisms
emphasize
investigation
strategies,
particularly
clinical
immunotherapy
microenvironment.
Nanotherapy
demonstrated
domain.
Future
directions
should
deepen
accelerate
translation
findings
provide
new
insights
innovation
development
