Investigative Ophthalmology & Visual Science,
Journal Year:
2024,
Volume and Issue:
65(14), P. 32 - 32
Published: Dec. 18, 2024
Intraocular
pressure
(IOP)
elevation
is
the
primary
risk
factor
and
currently
main
treatable
for
progression
of
glaucomatous
optic
neuropathy.
In
addition
to
direct
clinical
living
animal
in
vivo
studies,
ex
perfusion
anterior
segments
whole
eyes
a
key
technique
studying
conventional
outflow
function
as
it
responsible
IOP
regulation.
We
present
well-tested
experimental
details,
protocols,
considerations,
advantages,
limitations
several
model
systems
These
include:
(1)
perfused
globes,
(2)
stationary
segment
organ
culture,
(3)
human
(4)
(5)
corneal
rims,
(6)
wedges.
methods,
with
due
consideration
paid
their
strengths
limitations,
comprise
set
very
strong
tools
extending
our
understanding
Journal of Clinical Medicine,
Journal Year:
2023,
Volume and Issue:
12(20), P. 6599 - 6599
Published: Oct. 18, 2023
Herein,
we
provide
evidence
that
human
regulation
of
aqueous
outflow
is
by
a
pump-conduit
system
similar
to
the
lymphatics.
Direct
observation
documents
pulsatile
flow
into
Schlemm’s
canal
and
from
collector
channels,
intrascleral
veins,
episcleral
veins.
Pulsatile
in
vessels
requires
driving
force,
chamber
with
mobile
walls
valves.
We
demonstrate
trabecular
meshwork
acts
as
deformable,
wall
chamber:
canal.
A
tight
linkage
between
force
intraocular
pressure
deformation
causes
tissue
responses
milliseconds.
The
link
provides
sensory-motor
baroreceptor-like
function,
providing
maintenance
homeostatic
setpoint.
ocular
pulse
motion
oscillations
around
document
valves
entering
exiting
using
real-time
direct
microscope
multiple
additional
modalities.
Our
laboratory-based
high-resolution
SD-OCT
platform
quantifies
valve
lumen
opening
closing
within
milliseconds
synchronously
motion;
stiffens,
movement
slows
glaucoma
tissue.
novel
PhS-OCT
measures
nanometer-level
synchronous
subjects.
Movement
decreases
patients.
model
robust
because
it
anchors
laboratory
studies
physical
reality
humans
glaucoma.
Investigative Ophthalmology & Visual Science,
Journal Year:
2024,
Volume and Issue:
65(14), P. 32 - 32
Published: Dec. 18, 2024
Intraocular
pressure
(IOP)
elevation
is
the
primary
risk
factor
and
currently
main
treatable
for
progression
of
glaucomatous
optic
neuropathy.
In
addition
to
direct
clinical
living
animal
in
vivo
studies,
ex
perfusion
anterior
segments
whole
eyes
a
key
technique
studying
conventional
outflow
function
as
it
responsible
IOP
regulation.
We
present
well-tested
experimental
details,
protocols,
considerations,
advantages,
limitations
several
model
systems
These
include:
(1)
perfused
globes,
(2)
stationary
segment
organ
culture,
(3)
human
(4)
(5)
corneal
rims,
(6)
wedges.
methods,
with
due
consideration
paid
their
strengths
limitations,
comprise
set
very
strong
tools
extending
our
understanding
