Journal of Applied Polymer Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 23, 2025
ABSTRACT
Self‐healing
hydrogels
have
become
a
hot
research
topic
in
the
field
of
wound
care
due
to
their
ability
prevent
secondary
damage
dressing
and
reduce
risk
infection.
The
aim
this
study
was
develop
hydrogel
network
system
with
excellent
self‐healing
antimicrobial
properties,
which
is
particularly
suitable
for
applications.
stability
enhanced
by
forming
long
chains
through
lipoic
acid
(LA)
disulfide
bonding
inhibiting
chain
depolymerization
via
polygallic
(PGA)‐mediated
SAr
bonding.
In
addition,
poly(lysine)
(PL)
doped
into
electrostatic
interactions
further
enhance
structural
strength
properties
hydrogels.
This
noncovalent
gel
endowed
softness
fluidity,
enabling
them
adapt
various
shapes.
Through
experimental
results,
it
shown
that
not
only
possessed
mechanical
remarkable
ability,
but
also
exhibited
good
cytocompatibility.
Antimicrobial
tests
more
than
99.9%
effective
against
Escherichia
coli
Staphylococcus
aureus
.
Thus,
PLA/PGA/PL
self‐healing,
antimicrobial,
biocompatibility
shows
great
potential
application
as
dressings
becomes
strong
candidate
dressings.
Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(2), P. 229 - 229
Published: Feb. 10, 2025
Skin
disorders
are
the
fourth
most
common
cause
of
all
diseases,
which
affect
nearly
one-third
world’s
population.
Topical
drug
delivery
can
be
effective
in
treating
a
range
skin
disorders,
including
microbial
infections,
cancer,
dermatitis,
burn
injury,
wounds,
and
psoriasis.
Bioadhesive
nanoparticles
(BNPs)
serve
as
an
efficient
topical
system
they
dual
purposes
bioadhesives
nanocarriers,
mediate
targeted
delivery,
prolong
retention
time,
deepen
penetration
through
layers.
There
is
increasing
demand
for
BNP-based
applications
medicine
because
their
various
advantages,
biodegradability,
flexibility,
biocompatibility,
enhanced
adhesive
strength.
A
number
BNPs
have
already
been
developed
evaluated
potential
systems.
In
addition,
studies
carried
out
to
evaluate
treatment
atopic
irritant
contact
psoriasis,
severe
injuries.
This
review
article
timely
unique,
it
provides
extensive
unique
summary
recent
advances
wide-ranging
disorders.
Moreover,
this
also
useful
discussion
on
bioadhesion
mechanism
biopolymers
that
used
prepare
BNPs.
Biomacromolecules,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 17, 2025
The
skin
is
fragile,
making
it
very
vulnerable
to
damage
and
injury.
Untreated
wounds
can
pose
a
serious
threat
human
health.
Three-dimensional
polymer
network
hydrogels
have
broad
application
prospects
in
wound
dressings
due
their
unique
properties
structure.
therapeutic
effect
of
traditional
limited,
while
multifunctional
composite
show
greater
potential.
Multifunctional
regulate
moisture
through
formula
adjustment.
Moreover,
be
combined
with
bioactive
ingredients
improve
performance
healing
applications.
Stimulus-responsive
respond
specifically
the
environment
meet
needs
different
stages.
This
review
summarizes
material
types,
structure,
properties,
design
considerations,
formulation
strategies
for
hydrogel
used
healing.
We
discuss
various
types
recently
developed
dressings,
highlights
importance
tailoring
physicochemical
addresses
potential
challenges
preparing
dressings.
ChemistrySelect,
Journal Year:
2025,
Volume and Issue:
10(8)
Published: Feb. 1, 2025
Abstract
Chronic
wounds,
as
a
kind
of
long‐term
disease
that
is
difficult
to
cure,
are
challenged
in
healthcare,
placing
substantial
physical,
emotional,
and
economic
burdens
on
patients
society.
Effective
treatment
chronic
wounds
essential
for
improving
patient
quality
life,
reducing
healthcare
costs,
alleviating
the
strain
medical
resources.
Hydrogel
materials
have
emerged
promising
candidates
wound
due
their
exceptional
adaptability
environments
ability
deliver
various
therapeutic
agents,
effectively
promoting
healing
wounds.
However,
wide
array
available
with
diverse
functionalities
presents
challenge
selecting
most
appropriate
components
synthesizing
hydrogel
dressings.
This
review
summarizes
common
materials,
including
properties,
cross‐linking
methods,
applications.
Additionally,
it
systematically
categorizes
different
elucidating
action
mechanisms
effects.
Furthermore,
this
work
offers
guidance
material
selection
dressing
design
based
characteristics
Finally,
challenges
future
perspectives
composite
hydrogels
field
dressings
discussed.
provides
readers
comprehensive
understanding
reliable
basis
synthesize
ideal
Journal of Applied Polymer Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 23, 2025
ABSTRACT
Self‐healing
hydrogels
have
become
a
hot
research
topic
in
the
field
of
wound
care
due
to
their
ability
prevent
secondary
damage
dressing
and
reduce
risk
infection.
The
aim
this
study
was
develop
hydrogel
network
system
with
excellent
self‐healing
antimicrobial
properties,
which
is
particularly
suitable
for
applications.
stability
enhanced
by
forming
long
chains
through
lipoic
acid
(LA)
disulfide
bonding
inhibiting
chain
depolymerization
via
polygallic
(PGA)‐mediated
SAr
bonding.
In
addition,
poly(lysine)
(PL)
doped
into
electrostatic
interactions
further
enhance
structural
strength
properties
hydrogels.
This
noncovalent
gel
endowed
softness
fluidity,
enabling
them
adapt
various
shapes.
Through
experimental
results,
it
shown
that
not
only
possessed
mechanical
remarkable
ability,
but
also
exhibited
good
cytocompatibility.
Antimicrobial
tests
more
than
99.9%
effective
against
Escherichia
coli
Staphylococcus
aureus
.
Thus,
PLA/PGA/PL
self‐healing,
antimicrobial,
biocompatibility
shows
great
potential
application
as
dressings
becomes
strong
candidate
dressings.
