Radiopaque, Self-Immolative Poly(benzyl ether) as a Functional X-ray Contrast Agent: Synthesis, Prolonged Visibility, and Controlled Degradation

Biomacromolecules, Journal Year: 2024, Volume and Issue: 25(5), P. 2740 - 2748

Published: April 2, 2024

A self-immolative radiocontrast polymer agent has been newly designed for this study. The is composed of a degradable poly(benzyl ether)-based backbone that enables complete and spontaneous depolymerization upon exposure to specific stimulus, with iodophenyl pendant groups confer radiodensity comparable commercial agents. In particular, when incorporated into biodegradable polycaprolactone matrix, the not only reinforces matrix provides prolonged radiopacity without leaching but also governs overall degradation kinetics composite under basic aqueous conditions, allowing X-ray tracking exhibiting predictable until end its lifespan. Our design would be advanced various other components produce synergistic functions extended applications in implantable devices theragnostic systems.

Language: Английский

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Contrast media for hysterosalpingography: systematic search and review providing new guidelines by the Contrast Media Safety Committee of the European Society of Urogenital Radiology

European Radiology, Journal Year: 2024, Volume and Issue: 34(10), P. 6435 - 6443

Published: April 4, 2024

Hysterosalpingography (HSG) is widely used for evaluating the fallopian tubes; however, controversies regarding use of water- or oil-based iodine-based contrast media (CM) remain. The aim this work was (1) to discuss reported pregnancy rates related CM type used, (2) validate in published literature, (3) possible complications and side effects HSG, (4) develop guidelines on HSG.

Language: Английский

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Computed tomography technologies to measure key structural features of polymeric biomedical implants from bench to bedside

Journal of Biomedical Materials Research Part A, Journal Year: 2024, Volume and Issue: 112(11), P. 1893 - 1901

Published: May 10, 2024

Abstract Implanted polymeric devices, designed to encourage tissue regeneration, require porosity. However, characterizing porosity, which affects many functional device properties, is non‐trivial. Computed tomography (CT) a quick, versatile, and non‐destructive way gain 3D structural information, yet various CT technologies, such as benchtop, preclinical clinical systems, all have different capabilities. As system capabilities determine the information that can be obtained, seamless monitoring of key features through stages translation must engineered intentionally. Therefore, in this study we tested feasibility obtaining pre‐clinical systems high‐resolution micro‐CT (μCT) under physiological conditions. To overcome low contrast polymers hydrated environments, radiopaque nanoparticle agent was incorporated into porous devices. The size resolved structures highly dependent on resolution (voxel size) scan. voxel scan increased (lower resolution) from 5 50 μm, measured pore overestimated, percentage porosity underestimated by nearly 50%. With homogeneous introduction nanoparticles, changes structure could quantified state, including at high‐resolution. Biopolymers had significant post‐hydration, mean increase 130% wall thickness potentially impact biological response. By incorporating imaging facile monitor devices initial design translation.

Language: Английский

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Diagnosis and treatment status of inoperable locally advanced breast cancer and the application value of inorganic nanomaterials

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: June 25, 2024

Abstract Locally advanced breast cancer (LABC) is a heterogeneous group of that accounts for 10–30% cases. Despite the ongoing development current treatment methods, LABC remains severe and complex public health concern around world, thus prompting urgent requirement innovative diagnosis strategies. The primary challenges are inoperable clinical status ineffective local control methods. With rapid advancement nanotechnology, inorganic nanoparticles (INPs) exhibit potential application prospect in diagnosing treating cancer. Due to unique inherent characteristics INPs, different functions can be performed via appropriate modifications constructions, making them suitable imaging technology strategies schemes. INPs improve efficacy conventional radiotherapy treatment. In face LABC, have proposed new therapeutic methods fostered evolution novel such as photothermal photodynamic therapy, magnetothermal sonodynamic multifunctional nanoplatform. This article reviews advances accurate offers insights overcome existing difficulties management. Graphical

Language: Английский

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Polymer-based delivery systems with metal complexes as contrast agents for medical imaging

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 518, P. 216071 - 216071

Published: July 10, 2024

Language: Английский

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