Configuration‐Mediated Efficient Non‐Radiative Transition for R848‐Assisted Photothermal Immunotherapy to Inhibit Tumor Growth and Metastasis by An In Situ Tumor Vaccine Strategy DOI
Jianan Dai, Laiping Fang, Xuan Wang

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 3, 2024

Cancer metastasis remains a critical factor contributing to the current limitations in cancer treatment. Photothermal immunotherapy has emerged as safe and potent therapeutic approach, demonstrating capability suppress tumor growth metastasis. While researchers have extensively investigated various structural modifications enhance photothermal conversion performance, influence of molecular configuration received comparatively limited attention. In this study, we synthesized two isomers, CZTBT LVTBT, which possessed distinct configurations. characterized by flatter configuration, exhibited an extended absorption wavelength higher molar extinction coefficient. Its excited state facilitated stronger rotation for non-radiative transitions, leading high efficiency (PCE) 36.3 %. When combined with R848, LVTBT@R848 nanoparticles (NPs)-mediated functioned situ vaccine, promoting maturation dendritic cells (DCs), T cell infiltration, differentiation natural killer (NK) memory cells, thereby activating strong immune response. Consequently, it significantly inhibited both primary distant tumors, while also limiting lung summary, study proposed configuration-mediated transition strategy efficient immunotherapy, advancing frontiers organic agents (OPTAs) design synthesis.

Language: Английский

Exploring the principles and applications of non-metal photothermal catalysts: Insights from mechanistic differences with metal counterparts DOI
Yaocheng Deng, Huiling Liu,

Zhanpeng Zhou

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 534, P. 216579 - 216579

Published: March 6, 2025

Language: Английский

Citations

0
Organoplatinum Complex Exhibiting Aggregation-Enhanced Emission (AEE) and Dual-Channel Ion-Sensing Properties by Terminating the Molecular Configuration Transformation (MCT) and Excited-State Intramolecular Proton Transfer (ESIPT) DOI

Chencheng Li,

Jiang Zhao

Inorganic Chemistry, Journal Year: 2024, Volume and Issue: 63(25), P. 11757 - 11767

Published: June 12, 2024

Emitters produce weak emissions when they undergo structural changes such as molecular configuration transformation (MCT) or excited-state intramolecular proton transfer (ESIPT) but give out strong after terminating these distortions. Herein, an organoplatinum complex, Pt-ppy-ABP, carrying a salicylaldehyde-based Schiff base unit is synthesized. It exhibits emission in dilute solutions shows bright at the aggregated state interacting with F– and Zn2+. This suggests that it has aggregation-enhanced (AEE) property holds potential ion detection. Supported by theoretical calculations femtosecond transient absorption results, this complex suffers including MCT from square-planar to tetrahedral one, well rotation of monodentate ligand ESIPT, showing its solutions. At state, releases yellow because restraints rotation. Upon Zn2+, emits bright-red -green emissions, achieving detection limits 10–7 M. The sensing mechanism concluded deprotonation- coordination-induced ESIPT terminations, respectively. Given AEE ion-responsive application information encryption also explored. Finally, findings should provide valuable clues for developments chemosensors dual-channel recognition abilities.

Language: Английский

Citations

2
Isomer engineering for deep understanding of aggregation-induced photothermal enhancement in conjugated systems DOI Creative Commons
Peiyang Gu, Tengfei He,

Zuoyu Wang

et al.

Chemical Science, Journal Year: 2024, Volume and Issue: 15(33), P. 13351 - 13358

Published: Jan. 1, 2024

Two isomeric molecules are synthesized with varied sulfur atom positions. TBP–MPA exhibits aggregation-induced photothermal enhancement due to S⋯N non-covalent interactions, providing extra non-radiative transition channels in the aggregated state.

Language: Английский

Citations

2
Metallo‐supramolecular nanofibers based on type‐I photosensitizer for synergistic antibacterial therapy DOI

S. C. Lyu,

Lukun Li,

Jingdong Gao

et al.

Smart Molecules, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Abstract Photodynamic therapy (PDT) has shown great merits in treating microbial infections due to its absence of bacterial resistance. However, the pronounced hypoxic microenvironment limits therapeutic efficiency traditional type‐II PDT, which is highly dependent on oxygen. Here type‐I photosensitizer BTZ n ‐Py ( = 8, 20) coordinates with chemical antibacterial agent Ag + fabricate metallo‐supramolecular nanofibers. Under light irradiation, formed nanofibers could not only generate reactive oxygen species (ROS), 1 O 2 , but also produce ROS •− addressed issues within infected tissues. Moreover, acid‐ and photo‐active release from endowed controlled characteristic, showed good biocompatibility normal Owing photoinduced ROS, vitro vivo experiments confirmed significantly synergistic performance fibers against both Gram‐positive Gram‐negative bacteria.

Language: Английский

Citations

2
Controllable Self‐Assembly of V═O Metalloradical Complex with Intramolecular Charge Transfer for Enhanced NIR‐II Fluorescence Imaging‐Guided Photothermal Therapy DOI Open Access

Jianshuai Bao,

Zengyin Li,

Deliang Wang

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 14(4)

Published: Dec. 18, 2024

Near-infrared second region (NIR-II) fluorescence imaging provides enhanced tissue penetration, achieving efficient NIR-II and photoacoustic (PA)-guided photothermal therapy (PTT) all in one material remains a challenging yet promising approach cancer treatment. Herein, open-shell V═O metalloradical complex (VONc) is self-assembled into VONc nanospheres (VONc NPs). NPs exhibit light absorption from 300 to 1400 nm, spectra ranging 900 distinct signal even at 1550 nm. Moreover, outstanding photostability higher conversion efficiency of 46.6% than that closed-shell zinc naphthalocyanine nanorods (ZnNc NRs). centered serves as transient electron-withdrawing groups facilitate charge transfer (CT), introducing additional nonradiative energy dissipation pathways enhancing heat generation. In vitro experiments indicate highly effective action causes harm both mitochondria lysosomes, resulting the death tumor cells, ZnNc almost no cell killing contrast. vivo anti-tumor results demonstrate excellent imaging-guided PTT against tumors with favorable biosafety profile. "Centered boosting CT" toward metal complexes significant insight for developing single-material integrated nanosystems diagnostic therapeutic applications.

Language: Английский

Citations

1
Functional Group Effects for Photothermal Mass-energy Transfer in CO2 Capture and Conversion DOI

Bingyuan Zeng,

Tingting Xia, Yanli Sun

et al.

Chemical Research in Chinese Universities, Journal Year: 2024, Volume and Issue: 40(3), P. 451 - 461

Published: May 11, 2024

Language: Английский

Citations

0
Configuration‐Mediated Efficient Non‐Radiative Transition for R848‐Assisted Photothermal Immunotherapy to Inhibit Tumor Growth and Metastasis by An In Situ Tumor Vaccine Strategy DOI
Jianan Dai, Laiping Fang, Xuan Wang

et al.

Angewandte Chemie, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 3, 2024

Abstract Cancer metastasis remains a critical factor contributing to the current limitations in cancer treatment. Photothermal immunotherapy has emerged as safe and potent therapeutic approach, demonstrating capability suppress tumor growth metastasis. While researchers have extensively investigated various structural modifications enhance photothermal conversion performance, influence of molecular configuration received comparatively limited attention. In this study, we synthesized two isomers, CZTBT LVTBT, which possessed distinct configurations. characterized by flatter configuration, exhibited an extended absorption wavelength higher molar extinction coefficient. Its excited state facilitated stronger rotation for non‐radiative transitions, leading high efficiency (PCE) 36.3 %. When combined with R848, LVTBT@R848 nanoparticles (NPs)‐mediated functioned situ vaccine, promoting maturation dendritic cells (DCs), T cell infiltration, differentiation natural killer (NK) memory cells, thereby activating strong immune response. Consequently, it significantly inhibited both primary distant tumors, while also limiting lung summary, study proposed configuration‐mediated transition strategy efficient immunotherapy, advancing frontiers organic agents (OPTAs) design synthesis.

Language: Английский

Citations

0
Configuration‐Mediated Efficient Non‐Radiative Transition for R848‐Assisted Photothermal Immunotherapy to Inhibit Tumor Growth and Metastasis by An In Situ Tumor Vaccine Strategy DOI
Jianan Dai, Laiping Fang, Xuan Wang

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 3, 2024

Cancer metastasis remains a critical factor contributing to the current limitations in cancer treatment. Photothermal immunotherapy has emerged as safe and potent therapeutic approach, demonstrating capability suppress tumor growth metastasis. While researchers have extensively investigated various structural modifications enhance photothermal conversion performance, influence of molecular configuration received comparatively limited attention. In this study, we synthesized two isomers, CZTBT LVTBT, which possessed distinct configurations. characterized by flatter configuration, exhibited an extended absorption wavelength higher molar extinction coefficient. Its excited state facilitated stronger rotation for non-radiative transitions, leading high efficiency (PCE) 36.3 %. When combined with R848, LVTBT@R848 nanoparticles (NPs)-mediated functioned situ vaccine, promoting maturation dendritic cells (DCs), T cell infiltration, differentiation natural killer (NK) memory cells, thereby activating strong immune response. Consequently, it significantly inhibited both primary distant tumors, while also limiting lung summary, study proposed configuration-mediated transition strategy efficient immunotherapy, advancing frontiers organic agents (OPTAs) design synthesis.

Language: Английский

Citations

0