Introduction to the RSC Advances themed collection on nano and microscale modifications of biomaterials

RSC Advances, Journal Year: 2024, Volume and Issue: 14(17), P. 11614 - 11615

Published: Jan. 1, 2024

Andrzej Zieliński and Beata Majkowska-Marzec introduce the

In vitro biocompatibility evaluation of functional electrically stimulating microelectrodes on primary glia

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: Jan. 19, 2024

Neural interfacing devices interact with the central nervous system to alleviate functional deficits arising from disease or injury. This often entails use of invasive microelectrode implants that elicit inflammatory responses glial cells and leads loss device function. Previous work focused on improving implant biocompatibility by modifying electrode composition; here, we investigated direct effects electrical stimulation at interface. A high-throughput in vitro assesses primary cell response biphasic waveforms 0 mA, 0.15 1.5 mA was developed optimized. Primary mixed cultures were generated heterozygous CX3CR-1 +/EGFP mice, electrically stimulated for 4 h/day over 3 days using 75 μm platinum-iridium microelectrodes, biomarker immunofluorescence measured. Electrodes then imaged a scanning electron microscope assess sustained damage. Fluorescence microscopy analyses suggest varying degrees localized each assayed (Hoescht, EGFP, GFAP, IL-1β), result expands comparable vivo models. allows comparison breadth parameters, opens another avenue through which neural developers can improve longevity electrodes tissue.

Language: Английский

Surface Wave Phenomenon and Microstructure Evolution Mechanism of Electromagnetically Levitated Ternary Ti-Al-Fe Alloy

Journal of Alloys and Compounds, Journal Year: 2024, Volume and Issue: 1006, P. 176316 - 176316

Published: Sept. 3, 2024

Language: Английский