Applications and Developments of Gene Therapy Drug Delivery Systems for Neurological Disorders DOI
Ngoc Hong Nguyen,

Phuong‐Trang Nguyen‐Thi,

Thuy Trang Nguyen

et al.

Advanced Therapeutics, Journal Year: 2024, Volume and Issue: 7(12)

Published: Nov. 2, 2024

Abstract Neurological diseases (NDs) such as Alzheimer's disease, Parkinson's ischemic strokes, spinal cord injuries, and other similar conditions that continue to pose a substantial health economic burden on global scale. It is crucial tackle the difficulties provided by current medications due adverse effects its immunological reactions develop improved treatments for neurodegenerative illnesses. Gene therapy currently being extensively used in preclinical clinical studies various because of ability enhance delivery effectiveness treatments. Various gene techniques, including messenger RNA, small interfering antisense oligonucleotides, microRNA, CRISPR/Cas9 system, plasmid DNA, have been created address these difficulties. The goal this study provide clear overview pathophysiological underpinnings NDs illnesses while also illuminating recent developments vector technologies. goes over main classifications vectors, their individual benefits drawbacks, specific applications therapy.

Language: Английский

Brain Targeting Nanomedicines: Pitfalls and Promise DOI Creative Commons
Aleksandr Käkinen,

Yuhao Jiang,

Thomas P. Davis

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 4857 - 4875

Published: May 1, 2024

Abstract: Brain diseases are the most devastating problem among world's increasingly aging population, and number of patients with neurological is expected to increase in future. Although methods for delivering drugs brain have advanced significantly, none these approaches provide satisfactory results treatment diseases. This remains a challenge due unique anatomy physiology brain, including tight regulation limited access substances across blood-brain barrier. Nanoparticles considered an ideal drug delivery system hard-to-reach organs such as brain. The development new nanomaterial-based treatments has opened various opportunities scientists develop brain-specific systems that could improve outcomes disorders Alzheimer's disease, Parkinson's stroke tumors. In this review, we discuss noteworthy literature examines recent developments brain-targeted nanomedicines used Keywords: delivery, barrier, targeted nanoparticle, neurodegenerative diseases, stroke, cancer

Language: Английский

Citations

5
Unlocking the future: Precision oligonucleotide therapy for targeted treatment of neurodegenerative disorders DOI Creative Commons
Naitik Jain, Amrita Arup Roy,

Geethu Madhusoodanan

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 143515 - 143515

Published: April 1, 2025

Language: Английский

Citations

0
Targeting specific brain districts for advanced nanotherapies: A review from the perspective of precision nanomedicine DOI Creative Commons
Giulia Sierri,

Michela Patrucco,

Davide L. Ferrario

et al.

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2024, Volume and Issue: 16(5)

Published: Sept. 1, 2024

Abstract Numerous studies are focused on nanoparticle penetration into the brain functionalizing them with ligands useful to cross blood–brain barrier. However, cell targeting is also crucial, given that cerebral pathologies frequently affect specific cells or areas. Functionalize nanoparticles most appropriate elements, tailor their physical parameters, and consider brain's complex anatomy essential aspects for precise therapy diagnosis. In this review, we addressed state of art targeted drug delivery in diseased regions, outlining progress, limitations, ongoing challenges. We provide a summary overview general design principles can be applied nanotherapies, considering areas types affected by common disorders. then emphasize lingering uncertainties hinder translational possibilities nanotherapies clinical use. Finally, offer suggestions continuing preclinical investigations enhance overall effectiveness precision nanomedicine addressing neurological conditions. This article categorized under: Therapeutic Approaches Drug Discovery > Nanomedicine Neurological Disease Emerging Technologies

Language: Английский

Citations

2
Applications and Developments of Gene Therapy Drug Delivery Systems for Neurological Disorders DOI
Ngoc Hong Nguyen,

Phuong‐Trang Nguyen‐Thi,

Thuy Trang Nguyen

et al.

Advanced Therapeutics, Journal Year: 2024, Volume and Issue: 7(12)

Published: Nov. 2, 2024

Abstract Neurological diseases (NDs) such as Alzheimer's disease, Parkinson's ischemic strokes, spinal cord injuries, and other similar conditions that continue to pose a substantial health economic burden on global scale. It is crucial tackle the difficulties provided by current medications due adverse effects its immunological reactions develop improved treatments for neurodegenerative illnesses. Gene therapy currently being extensively used in preclinical clinical studies various because of ability enhance delivery effectiveness treatments. Various gene techniques, including messenger RNA, small interfering antisense oligonucleotides, microRNA, CRISPR/Cas9 system, plasmid DNA, have been created address these difficulties. The goal this study provide clear overview pathophysiological underpinnings NDs illnesses while also illuminating recent developments vector technologies. goes over main classifications vectors, their individual benefits drawbacks, specific applications therapy.

Language: Английский

Citations

1