Immunotherapy strategy for treating inflammatory bowel disease based on a nanozyme/total glucosides of paeony hybrid materials

Advanced Composites and Hybrid Materials, Journal Year: 2025, Volume and Issue: 8(1)

Published: Feb. 1, 2025

Inflammatory bowel disease (IBD) is a chronic gastrointestinal inflammatory condition that has long plagued patients. Herein, an innovative oral treatment strategy for IBD proposed, which utilizes calcium alginate hydrogel as carrier to deliver Co3O4 nanocages loaded with total glucosides of paeony (TGP) into the body. This design ingeniously exploits protective properties outer layer ensure enzyme not prematurely degraded when passing through acidic gastric juice. However, upon reaching inflamed intestinal site, overexpressed H2O2 there mixes specific solution, causing degrade and release Co3O4@TGP. These negatively charged nanozymes can precisely recognize accumulate in colonic tissue, achieving targeted therapy their unique charge characteristics. More importantly, itself possesses excellent catalytic activity, effectively consuming excess at site inflammation degrading 10 nm small particles process, while simultaneously releasing TGP. Together, they exert dual effects scavenging reactive oxygen species (ROS) anti-inflammation. Its therapeutic mechanism involves fine regulation expression key proteins such TLR7, MYD88, GAPDH, well effective inhibition NF-κB signaling pathway. series actions only reduces various pro-inflammatory cytokines (such TNF-α, IL-18, IL-1β, IL-6, HMGB1) but also promotes production anti-inflammatory cytokine IL-10, thereby maintaining integrity barrier. research achievement opens up novel path colitis.

Language: Английский

Viewpoints about the Application of Nanoprobe Technology in Orthopedic Diseases Based on Its Functions in Disease Diagnosis and Treatment

Nano Biomedicine and Engineering, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Language: Английский