MnNi@PVP Nanoenzyme Based on Regulating Inflammation and Immune Homeostasis for the Therapy of Inflammatory Bowel Disease DOI
Yingying Ren, Qiushu Chen, Zhiwei Lu

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(47), P. 64463 - 64475

Published: Nov. 13, 2024

Nanozymes exhibiting remarkable antioxidant capabilities represent an effective therapeutic approach for ulcerative colitis (UC). This study synthesized the MnNi@PVP nanoenzyme through high-temperature pyrolysis and NaCl template method, which exhibited multienzyme activity comprising glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT). investigated effect of on caused by sodium dextran sulfate (DSS). The findings indicated that notably decreased disease index (DAI) score, encompasses weight loss, colon shortening, histopathological changes. showed effectiveness in addressing oxidative damage suppressing levels proinflammatory markers, such as tumor necrosis factor (TNF-α), inducible nitric oxide synthase (iNOS), interleukin (IL)-6, inactivating TLR4 pathway macrophages. In addition, demonstrated ability to repair tight junction proteins (occludin ZO-1) restore intestinal barrier. transcriptome sequencing could regulate inflammatory expression pathways immune processes. Additionally, negatively charged can selectively bind inflamed colonic tissues electrostatic interactions, endowing it with targeted reparative at location inflammation. MnNi@PVP, possesses reactive oxygen nitrogen species (RONS) clearance capability examined this section, is expected provide basis function.

Language: Английский

Precision microbial regulation: Strategies for modulating GIT microbiota for host health DOI Creative Commons

Zhong Pei,

Qin Li, Yanmei Zhang

et al.

iMetaOmics., Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Abstract Recent advancements in analytical techniques have unveiled the spatiotemporal diversity of gastrointestinal tract (GIT) microbiota and their associations with host well‐being. Despite these insights, precise regulation GIT remains a significant challenge. Currently, microbial regulatory strategies, including fecal transplantation (FMT), synthetic communities (SynComs), genetically engineered microorganisms (GEMs), phages, nanomaterials, are increasingly utilized for influence on microbiota. This review emphasizes necessity developing targeted strategies provides comprehensive summary comparison approaches to explore potential. We discuss recent focusing mechanisms, efficacy, safety considerations, clinical trials, optimization at application level. Finally, we highlight support methods optimizing modulation timing regulation, selection targets, importance monitoring environment guide effective interventions.

Language: Английский

Citations

0
Revolutionizing Nanovaccines: A New Era of Immunization DOI Creative Commons
Mohammed A. Saleh,

Ahmed El-Moghazy,

Adel Helmy Elgohary

et al.

Vaccines, Journal Year: 2025, Volume and Issue: 13(2), P. 126 - 126

Published: Jan. 27, 2025

Infectious diseases continue to pose a significant global health threat. To combat these challenges, innovative vaccine technologies are urgently needed. Nanoparticles (NPs) have unique properties and emerged as promising platform for developing next-generation vaccines. revolutionizing the field of development, offering new era immunization. They allow creation more effective, stable, easily deliverable Various types NPs, including lipid, polymeric, metal, virus-like particles, can be employed encapsulate deliver components, such mRNA or protein antigens. These NPs protect antigens from degradation, target them specific immune cells, enhance antigen presentation, leading robust durable responses. Additionally, simultaneously multiple antigens, adjuvants, in single formulation, simplifying production administration. Nanovaccines offer approach food- water-borne bacterial diseases, surpassing traditional formulations. Further research is needed address burden infections. This review highlights potential revolutionize platforms. We explore their mechanisms action, current applications, emerging trends. The discusses limitations nanovaccines, solutions role artificial intelligence effective accessible nanovaccines infectious diseases.

Language: Английский

Citations

0
Incorporating zinc coordination driven nanozyme into chitosan and hyaluronic acid based nanoplatform for scavenging H2S/ROS in managing inflammatory bowel disease DOI
Jiafeng Zou, Wenxing Ding, You Chen

et al.

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: unknown, P. 123501 - 123501

Published: March 1, 2025

Language: Английский

Citations

0
An anti-miR-301a and zinc coordination driven nanozyme loaded in nanoparticle for oral therapy of inflammatory bowel disease based on colitis microenvironment regulation DOI
Jiafeng Zou, Chuanhe Xia, Min Yao

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161997 - 161997

Published: March 1, 2025

Language: Английский

Citations

0
“Three-birds, one-stone” biomimetic nanozyme system based on oxygen vacancy structure-regulated cascade reaction for inflammatory bowel disease DOI
Tianliang Li, Zhaoming Wang, Zhijie Wang

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162172 - 162172

Published: April 1, 2025

Language: Английский

Citations

0
Near-Infrared Light-Controlled Nitric Oxide Delivery Combined with In Situ Activated Chemotherapy for Enhanced Multimodal Therapy DOI

Bing Ren,

Jing Liu, Yi Wang

et al.

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Development of nanoplatforms with in situ activation for chemotherapy represents a promising modality biomedical application. Herein, multifunctional nanoplatform, CMS@DTC@PDA@RuNO@FA (abbreviated as CDPNF NPs), was developed highly efficient antitumor therapy, which diethyldithiocarbamate (DTC)-loaded mesoporous Cu2MoS4 (CMS) nanoparticles were covered by polydopamine (PDA) layers and further covalently modified NO donor (RuNO) folic acid (FA)-directing moiety. Under the mild acidic tumor microenvironment (TME), NPs co-liberated DTC Cu2+ site, where formation cytotoxic Cu(DTC)2 complex effectively killed cells. Furthermore, under near-infrared (NIR) light irradiation, could deliver nitric oxide (NO) produce superoxide anions (O2•-), followed more toxic peroxynitrite (ONOO-), led to promoted cell apoptosis. 1064 nm NIR vivo experiments demonstrated an impressively high inhibition rate (∼97%) while good biocompatibility. This work activated approach precision medicine that might imply its potential clinical applications.

Language: Английский

Citations

0
Tannic acid-etched PAN/PVP nanofibers loaded with Cu-MOFs enhance antibacterial efficacy and accelerate wound healing DOI
Zhenyu Wang, Jianxiang Li, Sihan Li

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 253, P. 114719 - 114719

Published: April 18, 2025

Language: Английский

Citations

0
An Oral H2S Responsive Cu5.4O Nanozyme Platform with Strong ROS/H2S Scavenging Capacity for the Treatment of Colitis DOI
Ma Ying, Yixing Tu, Yang Chen

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 17(1), P. 617 - 631

Published: Dec. 25, 2024

Inflammatory bowel disease involves excess reactive oxygen species (ROS) and hydrogen sulfide (H2S) at inflammatory sites. Nanozyme-mediated ROS H2S scavenging therapy is promising for colitis treatment. Here, we synthesized a multiple Cu5.4O nanoparticle first explored its capacity. Chitosan oligosaccharide modified with alpha-lipoic acid was coated on the nanoparticles to further enhance Furthermore, calcium alginate surface develop an oral nanoplatform (Cu5.4O@SAG) possessing dual-pH/H2S-responsive release characteristics. Importantly, Cu5.4O@SAG exhibited enrichment colonic inflammation site relieved index, containing recovery of colon length, spleen liver body weight, as well cell infiltration. In vivo in vitro experiments revealed dual capacities nanoplatform. Additionally, regulated tight junctions, mucus layers, gut microbiota, which accompanied by downregulation cytokines. Notably, also had excellent biocompatibility. conclusion, this multiple-scavenging nanozyme platform provides new safe paradigm development nanozymes

Language: Английский

Citations

1
MnNi@PVP Nanoenzyme Based on Regulating Inflammation and Immune Homeostasis for the Therapy of Inflammatory Bowel Disease DOI
Yingying Ren, Qiushu Chen, Zhiwei Lu

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(47), P. 64463 - 64475

Published: Nov. 13, 2024

Nanozymes exhibiting remarkable antioxidant capabilities represent an effective therapeutic approach for ulcerative colitis (UC). This study synthesized the MnNi@PVP nanoenzyme through high-temperature pyrolysis and NaCl template method, which exhibited multienzyme activity comprising glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT). investigated effect of on caused by sodium dextran sulfate (DSS). The findings indicated that notably decreased disease index (DAI) score, encompasses weight loss, colon shortening, histopathological changes. showed effectiveness in addressing oxidative damage suppressing levels proinflammatory markers, such as tumor necrosis factor (TNF-α), inducible nitric oxide synthase (iNOS), interleukin (IL)-6, inactivating TLR4 pathway macrophages. In addition, demonstrated ability to repair tight junction proteins (occludin ZO-1) restore intestinal barrier. transcriptome sequencing could regulate inflammatory expression pathways immune processes. Additionally, negatively charged can selectively bind inflamed colonic tissues electrostatic interactions, endowing it with targeted reparative at location inflammation. MnNi@PVP, possesses reactive oxygen nitrogen species (RONS) clearance capability examined this section, is expected provide basis function.

Language: Английский

Citations

0