Recent Progress in Microenvironment‐Responsive Nanodrug Delivery Systems for the Targeted Treatment of Rheumatoid Arthritis DOI
Shuhang Liu, Ming Yang, Han Liu

et al.

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2024, Volume and Issue: 16(6)

Published: Nov. 1, 2024

ABSTRACT Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that often causes joint pain, swelling, and functional impairments. Drug therapy the main strategy used to alleviate symptoms of RA; however, drug may have several adverse effects, such as nausea, vomiting, abdominal diarrhea, gastric ulcers, intestinal bleeding, hypertension, hyperglycemia, infection, fatigue, indigestion. Moreover, long‐term excessive use drugs cause liver kidney dysfunction, well thrombocytopenia. Nanodrug delivery systems (NDDSs) can deliver therapeutics diseased sites with controlled release payload in an abnormal microenvironment, which helps reduce side effects therapeutics. Abnormalities decreased pH, increased expression matrix metalloproteinases (MMPs), concentrations reactive oxygen species (ROS), are associated progression RA but also provide opportunity achieve microenvironment‐responsive therapeutic at site. Microenvironment‐responsive NDDSs overcome abovementioned disadvantages therapy. Herein, we comprehensively review recent progress development for treatment, including pH‐, ROS‐, MMP‐, multiresponsive NDDSs. Furthermore, pathological microenvironment highlighted detail.

Language: Английский

Innovative Rheumatoid Arthritis Management Using Injection Replacement Approach Via Dual Therapeutic Effects of Hyalurosomes-Encapsulated Luteolin and Dexamethasone DOI
Mariam Zewail, Passent M.E. Gaafar,

Haidy Abbas

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 249, P. 114497 - 114497

Published: Jan. 9, 2025

Language: Английский

Citations

1
Advances in the use of nanotechnology for treating gout DOI
Yizhen Wang, Zixuan Wang, Hui Jiang

et al.

Nanomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 15

Published: Jan. 28, 2025

Gout is a commonly occurring form of inflammatory arthritis caused by persistently elevated levels uric acid. Its incidence rate rises with the increases living standards and poor dietary habits, which has considerable impact on quality life patients. Although there wide assortment drugs available for management gout, effectiveness security these are limited their chemical stability insufficient targeting. Therefore, development effective nanomedicine systems to overcome problems treat gout becomes high priority. This review provides detailed introduction research progress developing advanced nanomedicines using polymers, hydrogel, nanocapsules, lipids, bionic vesicles, inorganic artificial organelles electronically controlled conveyor carriers improve therapy.

Language: Английский

Citations

1
Prodrug-inspired therapeutics: albuminized ceria nanozymes for osteoarthritis treatment DOI
Li Zhou,

Weikun Meng,

Yilin Wang

et al.

Composites Part B Engineering, Journal Year: 2024, Volume and Issue: 281, P. 111521 - 111521

Published: May 3, 2024

Language: Английский

Citations

6
Effectively alleviate rheumatoid arthritis via maintaining redox balance, inducing macrophage repolarization and restoring homeostasis of fibroblast-like synoviocytes by metformin-derived carbon dots DOI Creative Commons
Rui Zhang, Xingyu Lin, Rongjie Lin

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 29, 2025

Overproduction of reactive oxygen species (ROS), elevated synovial inflammation, hyperplasia and fibrosis are the main characteristic microenvironment in rheumatoid arthritis (RA). Macrophages fibroblast-like synoviocytes (FLSs) play crucial roles progression RA. Hence, synergistic combination ROS scavenging, macrophage polarization from pro-inflammatory M1 phenotype towards M2 anti-inflammatory phenotype, restoring homeostasis FLSs will provide a promising therapeutic strategy for In this study, we successfully synthesized metformin-derived carbon dots (MCDs), investigated antirheumatic effect vivo vitro. Designed MCDs could target inflamed cells accumulate at inflammatory joints collagen-induced (CIA) rats. investigation suggested that reduced inflammation hyperplasia, ultimately prevented cartilage destruction, bone erosion, CIA addition, eliminated cellular macrophages RA through enzyme-like catalytic activity as well inhibiting NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome signaling pathway, effectively polarizing them into to realize effect. Furthermore, inhibit proliferation, migration, FLSs. Mechanistically, restored while reducing level by blocking IL-6/gp130 pathway. Combined with preferable biocompatibility, offer prospective treatment approach

Language: Английский

Citations

0
Locally administered liposomal drug depot enhances rheumatoid arthritis treatment by inhibiting inflammation and promoting cartilage repair DOI Creative Commons
Zongquan Zhang, Guan Wang, Zhuo Zhang

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 31, 2025

Rheumatoid arthritis (RA) is a chronic autoimmune condition characterized by synovial hyperplasia, where inflammatory macrophages within the joint synovium produce multiple cytokines, leading to cartilage damage. The development of therapeutic strategies that combine anti-inflammatory effects and repair mechanisms holds great promise for effective RA treatment. To address limitations associated with off-target intravenous administration risk cavity infection repeated local injections, we have innovatively developed liposomal drug depot through hyaluronic acid (HA)-modified liposomes encapsulating dexamethasone sodium phosphate (DSP)-loaded nanogels, termed HA-Lipo@G/D. nanogels were prepared ionic cross-linking chondroitin sulfate gelatin, both which notable properties. In vitro studies demonstrated this formulation exhibited sustained release, enhanced uptake macrophages, reduced secretion factors (TNF-α, IL-1β), significantly decreased chondrocyte apoptosis induced factors. Moreover, in vivo assessments rat model collagen-induced revealed accumulation at inflamed site, resulting macrophage repolarization tissue repair. Our findings provide synergistic strategy inhibiting inflammation mitigating damage injection, thereby enhancing efficacy RA.

Language: Английский

Citations

0
Targeted nanoliposomes for precision rheumatoid arthritis therapy: a review on mechanisms and in vivo potential DOI Creative Commons

Rukaiyya T. Girase,

Nayan A. Gujarathi,

Amey Sukhia

et al.

Drug Delivery, Journal Year: 2025, Volume and Issue: 32(1)

Published: Feb. 1, 2025

Rheumatoid arthritis (RA) is an inflammatory immune-triggered disease that causes synovitis, cartilage degradation, and joint injury. In nanotechnology, conventional liposomes were extensively investigated for RA. However, they frequently undergo rapid clearance, reducing circulation time therapeutic efficacy. Additionally, their stability in the bloodstream often compromised, resulting premature drug release. The current review explores potential of targeted liposomal-based nanosystems treatment It highlights pathophysiology RA, selective targeting sites, elucidates diverse mechanisms novel liposomal types applications. Furthermore, strategies pH-sensitive, flexible, surface-modified, PEGylated, acoustic, ROS-mediated, biofunctionalized are addressed. Targeted nanoliposomes showed precisely delivering drugs to CD44, SR-A, FR-β, FLS, toll-like receptors through high affinity ligands. vitro studies interpreted stable release profiles improved stability. Ex vivo on skin demonstrated ultradeformable glycerol-conjugated enhanced penetrability. experiments rat model depicted remarkable efficacy swelling, pro-inflammatory cytokines, synovial hyperplasia. conclusion, these represented a significant leap forward delivery, offering effective options future, integrating advanced with artificial intelligence, immunotherapy, precision medicine holds great promise.

Language: Английский

Citations

0
Treatment of rheumatoid arthritis using dual-targeted and dual-response intelligent micelles: a “three birds with one stone” strategy DOI Creative Commons

Rui-bo Guo,

Lu Zhang, Yang Liu

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 1, 2025

Rheumatoid arthritis (RA) is an autoimmune disease whose pathophysiology closely related to inflammation-associated cells and the microenvironment of inflamed joints. This study aimed develop dual-targeted, reactive oxygen species (ROS)/pH dual-responsive, size-shrinkable intelligent micelles targeting M1 macrophages fibroblast-like synoviocytes (FLSs) enhance drug efficacy safety. These were surface-modified with PEG5000 prolong their circulation time in bloodstream hide molecules. The optimized particle size allowed reside joints through extravasation leaky vasculature subsequent inflammatory cell-mediated sequestration (ELVIS) effect. high concentration ROS joint caused detachment hydration layer PEG5000, which was then specifically recognized internalized by FLSs via CD44 receptor-mediated endocytosis, ultimately allowing release into acidic environment cells. vivo vitro evaluation showed that precisely targeted site, thus inhibiting expression pro-inflammatory cytokines, reversing polarization macrophages, invasion migration proliferative FLSs, and, at same time, regulating seeds soils RA. "three birds one stone" approach multiple aspects RA, opening new horizons for comprehensive treatment

Language: Английский

Citations

0
New Dawn in the Treatment of Rheumatoid Arthritis: Advanced Insight into Polymer Hydrogel Research DOI Creative Commons
Shuai Wang, Jinyang Li,

Fazhan Ren

et al.

Gels, Journal Year: 2025, Volume and Issue: 11(2), P. 136 - 136

Published: Feb. 15, 2025

As a chronic systemic autoimmune disease, rheumatoid arthritis (RA) not only damages joints and other organs or systems throughout the body but also torments patients' physical mental health for long time, seriously affecting their quality of life. According to incomplete statistics at present, global prevalence RA is approximately 0.5-1%, number patients increasing year by year. Currently, drug therapies are usually adopted treatment RA, such as non-steroidal anti-inflammatory drugs (NSAIDs), disease-modifying antirheumatic (DMARDs), glucocorticoids/steroids, so on. However, traditional therapy has problems half-lives, cycles requiring frequent administration, lack specificity, possible adverse reactions (such gastrointestinal side effects, skin stratum corneum barrier damage, toxicity), which greatly restrict RA. In order improve limitations drug, physical, surgical treatments large related studies on have been carried out. Among them, hydrogels widely used in research due excellent biocompatibility, mechanical properties, general adaptability. For example, can be injected into synovial cavity fluid reduce wear between joints, lubricate avoid surface degradation. This article reviews applications under different functions situation carriers through delivery routes confirms outstanding potential great significance.

Language: Английский

Citations

0
Biomimetic Nanoparticles Inhibit the HIF-1α/iNOS/NLRP3 Pathway to Alleviate Rheumatoid Arthritis DOI

Mo Chen,

Zhenhua Wang,

Haolong Chen

et al.

Nano Letters, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Rheumatoid arthritis (RA) is a chronic autoimmune disease distinguished by inflammatory synovitis. Chrysin can alleviate the response and inhibit progression of RA. However, unfavorable physicochemical properties nonselective biodistribution chrysin make it difficult to achieve good therapeutic efficacy. To address these challenges, we developed biomimetic nanocarrier enhance targeted delivery synoviocytes, key cellular component in RA pathology. Our nanodrug, FMPlipo@C, was engineered integrating fibroblast-like synoviocyte (FLS) membrane proteins into chrysin-loaded liposomes. This innovative approach harnesses homologous targeting mediated FLS direct liposomes inflamed joints, facilitating cargo release within synoviocytes. We showed that FMPlipo@C reduces inflammation collagen-induced rheumatoid (CIA) model mice inhibiting HIF-1α/iNOS/NLRP3 pathway, protecting cartilage, preventing bone erosion, thus reducing swelling stiffness. study offers valuable insights development novel strategies for treatment

Language: Английский

Citations

0
NaHS@Cy5@MS@SP nanoparticles improve rheumatoid arthritis by inactivating the Hedgehog signaling pathway through sustained and targeted release of H2S into the synovium DOI Creative Commons
Xuexue Zhu,

An‐Jing Xu,

Weiwei Cai

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 8, 2025

Aberrant proliferation and inflammation of fibroblast-like synoviocytes (FLSs) significantly contribute to the pathogenesis rheumatoid arthritis (RA). Deficiency hydrogen sulfide (H2S) is a driving force for development RA, short half-life H2S-releasing donor sodium hydrosulfide (NaHS) limits its clinical application in RA therapy. Designing targeted delivery system with slow-release properties FLSs could offer novel strategies treating RA. Herein, we designed strategy achieve slow release H2S synovium, which was accomplished by synthesizing NaHS-CY5@mesoporous silic@LNP peptide Dil (NaHS@Cy5@MS@SP) nanoparticles. Our results demonstrated that NaHS@Cy5@MS@SP effectively targets FLSs, upregulates its-producing enzyme cystathionine-γ-lyase (CSE) joints arthritic mice. Overexpression CSE inhibited proliferation, migration, upon lipopolysaccharide (LPS) exposure, effects were mimicked NaHS@Cy5@MS@SP. In vivo studies showed achieved threefold higher AUCinf than free NaHS, improving bioavailability NaHS. Further, synovial hyperplasia reduced bone cartilage erosion DBA/1J mouse model collagen-induced (CIA), superior RNA sequencing molecular validated inactivated Hedgehog signaling pathway as evidenced reductions protein expression SHH, SMO, GLI1 phosphorylated p38/MAPK. This study highlights promising controlled synoviocytes, offering potential management.

Language: Английский

Citations

0