Emerging strategies for nitric oxide production and their topical application as nanodressings to promote diabetic wound healing

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 29, 2025

The challenges associated with prolonged healing or non-healing of chronic diabetic wounds contribute significantly to the increased incidence lower limb amputation. A pivotal factor in impediment is reduced production endogenous nitric oxide (NO) due hyperglycemic microenvironment typical diabetes. While both and exogenous NO have been shown promote process wounds, direct application wound management limited its gaseous nature risk explosive release. This review summarizes recent advances nanodressings incorporating donors treatment detailing specific conditions under which these facilitate release, a focus on beneficial effects NO, strategies for supplementation, encountered clinical translation as clinically viable nanomedicine context improving healing.

Language: Английский

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Engineered hydrogel platform for diabetic wound healing

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160379 - 160379

Published: Feb. 1, 2025

Language: Английский

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Advances in the study of polysaccharide-based hydrogel wound dressings

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142134 - 142134

Published: March 1, 2025

Language: Английский

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Advances in the development of medical dressings for the treatment of diabetic foot wounds

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 498, P. 155575 - 155575

Published: Sept. 7, 2024

Language: Английский

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Polysaccharide-based chondroitin sulfate macromolecule loaded hydrogel/scaffolds in wound healing- A comprehensive review on possibilities, research gap, and safety assessment

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 279, P. 135410 - 135410

Published: Sept. 6, 2024

Language: Английский

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Bioinspired programmed antibiofilm strategies for accelerated wound healing via spatiotemporally controlled enzyme nanoreactors

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113582 - 113582

Published: March 1, 2025

Language: Английский

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Prodigiosin Loaded SN‐PB@PG NPs‐Based Multimodal Therapy for the Healing of Bacterial Infected Chronic Wounds

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 23, 2025

Abstract Healing of infected chronic wounds faces dual challenges: persistent inflammation and impaired angiogenesis. To address these, SN‐PB@PG nanocomplexes were prepared by hybridisation nitroprusside (SNP) with Prussian blue (SN‐PB NPs) loaded prodigiosin (PG). Under near‐infrared (NIR) irradiation, SN‐PB NPs generated mild hyperthermia, facilitating the release nitric oxide (NO) PG to combat bacterial biofilms multidrug‐resistant pathogens. The in vivo assay using diabetic demonstrated that NIR reduced wound area 10.6% 11th day, which is superior control group (29.6%). In flap transplantation experiments, data showed only have a necrobiosis 3.8% flaps on 8th 31.3% group. Additionally, NO promoted vascular regeneration up‐regulating endothelial growth factor (VEGF) platelet cell adhesion molecule‐1 (CD31), regenerated sarcomeric tissue down‐regulating MMP‐9. results indicated combination gas photothermal therapy exerted combined antibacterial healing effect. Compared traditional clinical methods such as surgical debridement hyperbaric oxygen therapy, this new strategy efficiently addresses issues infection healing, convenient for application.

Language: Английский

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Cascade Nanozyme-Loaded Sprayable Hydrogels for Fibroblast Rejuvenation and Diabetic Wound Regeneration

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: March 29, 2025

Multifunctional composite wound dressings hold significant promise for diabetic healing. However, the detrimental role of advanced glycation end-products (AGEs)-reactive oxygen species (ROS) cycle in impeding repair remains underexplored. To disrupt this pathological cycle, zeolitic imidazolate framework-8 (ZIF-8) encapsulated cerium dioxide (CeO2) and adsorbed glucose oxidase (GOx) nanozyme particles ((ZIF-8@CeO2)@GOx, zcg) were loaded into a methacrylic anhydride-modified gelatin (GelMA) hydrogel to form sprayable dressing, zcg/GelMA (zcgG). Physicochemical characterization revealed that GOx catalyzes oxidation, triggering ZIF-8 acid-mediated decomposition release zinc ions CeO2 nanoparticles, thereby enabling cascade depletion, antioxidant, antiglycation functions. In vitro antimicrobial cytotoxicity experiments optimized zcg concentration GelMA. Under oxidative hyperglycemic culture conditions, we validated mechanism blocking AGEs-ROS restoring fibroblast mitochondrial membrane potential, subsequently suppressing cellular senescence. bacterial-infected rat skin model, zcgG group demonstrated substantially reduced inflammatory levels, 68% decrease AGEs, 1.9-fold increase collagen deposition compared blank controls. Within 2 weeks, achieved complete closure, while control retained 28% initial area. This work provides preliminary evidence feasibility using nanozymes break promote

Language: Английский

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Application of Drug Delivery System Based on Nanozyme Cascade Technology in Chronic Wound

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(32)

Published: Oct. 14, 2024

Abstract Chronic wounds are characterized by long‐term inflammation, including diabetic ulcers, traumatic etc., which provide an optimal environment for bacterial proliferation. At present, antibiotics the main clinical treatment method chronic wound infections. However, overuse of may accelerate emergence drug‐resistant bacteria, poses a significant threat to human health. Therefore, there is urgent need develop new therapeutic strategies Nanozyme‐based antimicrobial therapy (NABT) emerging strategy with broad‐spectrum activity and low drug resistance compared traditional antibiotics. NABT has shown great potential as catalyzing generation reactive oxygen species (ROS) its enzyme‐like catalytic properties, producing powerful bactericidal effect without developing resistance. cascade technology offers approach infection control, effectively improving efficacy activating cascades against cell membranes intracellular DNA while minimizing side effects. it worth noting that this still in early stages research. This article comprehensively reviews classification, current methods infection, different types nanozymes, application nanozyme reaction therapy, future challenges prospects.

Language: Английский

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Carboxymethyl chitosan nanoparticle-modulated cationic hydrogels doped with copper ions for combating bacteria and facilitating wound healing

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: Sept. 20, 2024

The simultaneous administration of antibacterial treatment and acceleration tissue regeneration are crucial for the effective healing infected wounds. In this work, we developed a facile hydrogel (PCC hydrogel) through coordination hydrogen interactions by polymerizing acrylamide monomers in presence carboxymethyl chitosan nanoparticles copper ions. prepared PCC demonstrated bacterial capture from wound exudation exhibited potent bactericidal activity against methicillin-resistant Staphylococcus aureus (MRSA) Pseudomonas aeruginosa . Furthermore, slow release ions facilitated promoting cell migration, collagen deposition angiogenesis. Additionally, possessed excellent biocompatibility hemostatic properties. practical effectiveness addressing infections facilitating was verified using mouse model MRSA-induced infections. Overall, work presents simple yet efficient multifunctional platform that integrates activity, promotion healing, hemostasis managing bacteria-associated

Language: Английский

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