Chemical Communications, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 27, 2024
A covalent organic framework-based multifunctional nanomedicine, CuO2@COF-SNO, which can produce reactive oxygen and nitrogen species (ROS/RNS) to enhance chemodynamic therapy of tumors.
Language: Английский
Polymers, Journal Year: 2025, Volume and Issue: 17(8), P. 1010 - 1010
Published: April 9, 2025
Hypoxic tumors pose considerable obstacles to cancer treatment, as diminished oxygen levels can impair drug effectiveness and heighten therapeutic resistance. Oral cancer, a prevalent malignancy, encounters specific challenges owing its intricate anatomical structure the technical difficulties in achieving complete resection, thereby often restricting treatment efficacy. The impact of hypoxia is particularly critical influencing both response prognosis oral cancers. This article summarizes examines potential polymer nanomedicines address these challenges. By engineering that specifically react hypoxic tumor microenvironment, pharmaceuticals markedly enhance targeting precision effectiveness. Polymer efficacy while reducing side effects by hypoxia-targeted accumulation. emphasizes overcome resistance frequently observed improving delivery bioavailability anticancer agents. Furthermore, this review elucidates design application for treating tumors, highlighting their transformative therapy. Finally, gives an outlook on stimuli-responsive polymeric cancer.
Language: Английский
Citations
0
IGI Global eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 503 - 530
Published: April 25, 2025
Despite the widespread use of traditional cancer therapies such as surgery, chemotherapy, and radiation, these approaches often suffer from significant drawbacks. Nanomaterials (NMs) are a promising alternative due to their distinct nanoscale properties which enable more precise drug delivery reduced off-target effects. Recently, cuproptosis ferroptosis have emerged novel forms programmed cell death regulated by metal ions, offering pathways for therapy. Cuproptosis, caused copper ion accumulation, leads mitochondrial dysfunction, while ferroptosis, driven iron-mediated lipid peroxidation, disrupts cellular integrity through oxidative stress. Here, we propose explore how NMs can be harnessed induce metalloptosis, advanced treatment strategies. Variations in NM size, morphology, synergistic effects composite complicate identification individual mechanisms. Use therapy, requires focusing on design regulation metalloptosis pathways.
Language: Английский
Citations
0
Nano Today, Journal Year: 2025, Volume and Issue: 63, P. 102771 - 102771
Published: April 23, 2025
Language: Английский
Citations
0
European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 117754 - 117754
Published: May 1, 2025
Language: Английский
Citations
0
Cancers, Journal Year: 2024, Volume and Issue: 16(21), P. 3581 - 3581
Published: Oct. 24, 2024
The significant expansion of nanobiotechnology and nanomedicine has led to the development innovative effective techniques combat various pathogens, demonstrating promising results with fewer adverse effects. Metal peroxide nanoparticles stand out among crucial yet often overlooked types nanomaterials, including metals. These are key in producing oxygen (O
Language: Английский
Citations
2
International Journal of Biological Sciences, Journal Year: 2024, Volume and Issue: 20(12), P. 4872 - 4887
Published: Jan. 1, 2024
Breast cancer (BC) persists as a highly prevalent malignancy in females, characterized by diverse molecular signatures and necessitating personalized therapeutic approaches. The equilibrium of copper within the organism is meticulously maintained through regulated absorption, distribution, elimination, underpinning not only cellular but also various essential biological functions. process cuproptosis initiated copper's interaction with lipoylases tricarboxylic acid (TCA) cycle, which triggers conglomeration lipoylated proteins diminishes integrity Fe-S clusters, culminating cell demise proteotoxic stress. In BC, aberrations are prominent represent crucial incident that contributes to disease progression. It influences BC metabolism affects critical traits such proliferation, invasiveness, resistance chemotherapy. Therapeutic strategies target have shown promising antitumor efficacy. Moreover, plethora cuproptosis-centric genes, including cuproptosis-related genes (CRGs), CRG-associated non-coding RNAs (ncRNAs), cuproptosis-associated regulators, been identified, offering potential for development risk assessment models or diagnostic signatures. this review, we provide comprehensive exposition fundamental principles cuproptosis, its influence on malignant phenotypes prognostic implications cuproptosis-based markers, substantial prospects exploiting therapy, thereby laying theoretical foundation targeted interventions domain.
Language: Английский
Citations
1
Materials Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 9(2), P. 189 - 203
Published: Nov. 26, 2024
This mini-review briefly but relatively comprehensively summarizes recent advances in exogenous/endogenous stimuli-responsive nanocatalysts that trigger situ chemical reactions for tumor catalytic therapy, and discusses the future challenges.
Language: Английский
Citations
1
Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 527, P. 216402 - 216402
Published: Dec. 25, 2024
Language: Английский
Citations
1
Published: Jan. 1, 2024
Language: Английский
Citations
0
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 139134 - 139134
Published: Dec. 1, 2024
Language: Английский
Citations
0