Glutathione-Responsive Nanoplatforms Based on Coordination between Fe3+ and Apigenin for Synergistic Chemo/Chemodynamic Therapy DOI

Zhi-Hang He,

Hanxiao Tang,

Yanna Pan

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 10, 2024

The oxygen consumption during chemodynamic therapy (CDT) can lead to severe cellular hypoxia, resulting in an increase the hypoxia inducible factor-1α (HIF-1α) level, which hinders effectiveness of CDT and induces tumor metastasis. Here, we propose a strategy synergistic between HIF-1α inhibitor avoid limitations reduce risk Herein, based on coordination Fe3+ apigenin (API, inhibitor), constructed hyaluronic acid (HA)-modified API-Fe nanoparticles (AF@HA NPs) for synergetic chemotherapy glutathione (GSH)-activated self-enhancing CDT. AF@HA NPs have high drug loading capacity, stability, biocompatibility. Furthermore, overexpressed GSH cancer cells Fe2+, weakened API Fe, promoted release chemotherapy. Fe2+ could react with endogenous H2O2 generate hydroxyl groups In addition, released inhibit expression sensitivity reactive species (ROS), thereby achieving effect results vitro vivo experiments indicated that effectively growth suppress lung metastasis cells.

Language: Английский

Research progress on quercetin in improving the survival rate of random skin flap DOI

Siping Xu,

Wenhua Zhang, Xuanfen Zhang

et al.

Archives of Dermatological Research, Journal Year: 2025, Volume and Issue: 317(1)

Published: Jan. 16, 2025

Language: Английский

Citations

0
Metal–organic framework microneedles for precision transdermal drug delivery: design strategy and therapeutic potential DOI

Yutong Jing,

Xueting Liu,

Yajing Zhu

et al.

Nanoscale, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

This review explores the synergistic potential of MOF-based MNs and details strategies for integrating MOFs various guest molecules within into to enhance transdermal therapeutic applications.

Language: Английский

Citations

0
Multifunctional Hydrogel Integrated Hemangioma Stem Cell‐Derived Nanovesicle‐Loaded Metal‐Polyphenol Network Promotes Diabetic Flap Survival DOI Open Access
Rui Chang, Pei Wang, Hongrui Chen

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

Abstract Diabetes‐associated skin defects represent a significant global health challenge. While flap grafts have been preferred treatment for soft‐tissue injuries in diabetic patients, their survival is often compromised by impaired vascularization, infection, and the adverse pathological microenvironment. To address these limitations, hybrid photo‐crosslinkable hydrogel (HPC) integrated hemangioma stem cell‐derived nanovesicle (HemV)‐loaded dual‐metal‐polyphenol network (dMPN) (HemV@dMPN/HPC) developed. HemVs, derived from highly vascularized infantile tissues, play key role promoting cell proliferation angiogenesis. The dMPN facilitates gradual release of copper (Cu 2+ ) magnesium ions (Mg ), stimulating angiogenesis mitigating inflammation. HPC further sustains ion while preserving therapeutic efficacy HemVs. Moreover, both Cu act to confer antibacterial properties, accelerating wound healing. This multifunctional HemV@dMPN/HPC platform offers promising strategy treating large can potentially improve graft survival.

Language: Английский

Citations

0
Investigating the Functionality of a Cobalt Metal‒Organic Framework for Dye Adsorption, Antimicrobial and Cytotoxicity Activity DOI

Chandandeep Kaur Behl,

Archana Thakur

Journal of Inorganic and Organometallic Polymers and Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 3, 2025

Language: Английский

Citations

0
Microneedle-aided nanotherapeutics delivery and nanosensor intervention in advanced tissue regeneration DOI Creative Commons

Churong Xu,

Fei Wu,

Zhouyi Duan

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: May 3, 2025

Language: Английский

Citations

0
Glutathione-Responsive Nanoplatforms Based on Coordination between Fe3+ and Apigenin for Synergistic Chemo/Chemodynamic Therapy DOI

Zhi-Hang He,

Hanxiao Tang,

Yanna Pan

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 10, 2024

The oxygen consumption during chemodynamic therapy (CDT) can lead to severe cellular hypoxia, resulting in an increase the hypoxia inducible factor-1α (HIF-1α) level, which hinders effectiveness of CDT and induces tumor metastasis. Here, we propose a strategy synergistic between HIF-1α inhibitor avoid limitations reduce risk Herein, based on coordination Fe3+ apigenin (API, inhibitor), constructed hyaluronic acid (HA)-modified API-Fe nanoparticles (AF@HA NPs) for synergetic chemotherapy glutathione (GSH)-activated self-enhancing CDT. AF@HA NPs have high drug loading capacity, stability, biocompatibility. Furthermore, overexpressed GSH cancer cells Fe2+, weakened API Fe, promoted release chemotherapy. Fe2+ could react with endogenous H2O2 generate hydroxyl groups In addition, released inhibit expression sensitivity reactive species (ROS), thereby achieving effect results vitro vivo experiments indicated that effectively growth suppress lung metastasis cells.

Language: Английский

Citations

0