Hydration Effects Driving Network Remodeling in Hydrogels during Cyclic Loading DOI Creative Commons

Baptiste Le Roi,

Joshua M. Grolman

ACS Macro Letters, Journal Year: 2025, Volume and Issue: unknown, P. 176 - 181

Published: Jan. 27, 2025

In complex networks and fluids such as the extracellular matrix, mechanical properties are substantially affected by movement of polymers both part entrapped in network. As many cells sensitive to remodeling their surroundings, it is important appreciate how may inhibit or facilitate Here, we explore a molecular-level understanding network hydrogel environment through successive compressive loading role that noninteracting play dynamic We find this highly localized time-dependent effect, with one major driving factors matrix interaction water within calcium-cross-linked alginate. Our results suggest more general mechanistic remodeling, implications for tissue transformations disease, biomaterials, food science formulation.

Language: Английский

Inflammation Targeting‐Triggered Healing Hydrogel for In Situ Reconstruction of Colonic Mucosa DOI Creative Commons
Gaoxian Chen, Xinyi Li, Wei Xu

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

Inflammatory bowel disease (IBD) is characterized by intestinal mucosal damage that exacerbates inflammation and promotes recurrence. Although hydrogel-based therapies have shown potential for repair, challenges remain due to inadequate targeting low hydrogel density, leading ongoing infiltration of harmful substances delayed healing. In this study, an inflammation-targeting-triggered healing (ITTH hydrogel) developed, composed polyvinyl alcohol-alginate microgels (PALMs) a cyclodextrin polymer crosslinker (CPC). This specifically targets inflamed colonic sites crosslinks in situ form dense network. The results demonstrate the ITTH adheres effectively tissue both IBD mouse models human samples. crosslinked network acts like barrier, preventing penetration detrimental such as bacteria small molecules, thereby protecting underlying tissue. Furthermore, significantly improved therapeutic outcomes mice with dextran sulfate sodium (DSS)-induced colitis. These findings suggest promising candidate reconstruction mucosa treatment IBD.

Language: Английский

Citations

0
Hydration Effects Driving Network Remodeling in Hydrogels during Cyclic Loading DOI Creative Commons

Baptiste Le Roi,

Joshua M. Grolman

ACS Macro Letters, Journal Year: 2025, Volume and Issue: unknown, P. 176 - 181

Published: Jan. 27, 2025

In complex networks and fluids such as the extracellular matrix, mechanical properties are substantially affected by movement of polymers both part entrapped in network. As many cells sensitive to remodeling their surroundings, it is important appreciate how may inhibit or facilitate Here, we explore a molecular-level understanding network hydrogel environment through successive compressive loading role that noninteracting play dynamic We find this highly localized time-dependent effect, with one major driving factors matrix interaction water within calcium-cross-linked alginate. Our results suggest more general mechanistic remodeling, implications for tissue transformations disease, biomaterials, food science formulation.

Language: Английский

Citations

0