Liposome‐Enabled Nanomaterials for Muscle Regeneration

Small Methods, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Abstract Muscle regeneration is a vital biological process that crucial for maintaining muscle function and integrity, particularly the treatment of diseases such as sarcopenia muscular dystrophy. Generally, tissues can self‐repair regenerate under various conditions, including acute or chronic injuries, aging, genetic mutation. However, becomes challenging beyond certain threshold, in severe injuries progressive diseases. In recent years, liposome‐based nanotechnologies have shown potential promising therapeutic strategies regeneration. Liposomes offer an adaptable platform targeted drug delivery due to their cell membrane‐like structure excellent biocompatibility. They enhance solubility, stability, while minimizing systemic side effects by different mechanisms. This review summarizes advancements, discusses current applications mechanisms, highlights challenges future directions possible clinical translation nanomaterials It hoped this offers new insights into development liposome‐enabled nanomedicine address limitations.

Language: Английский

3D-printed bioceramic scaffolds for bone defect repair: bone aging and immune regulation

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: March 28, 2025

The management of bone defects, particularly in aging populations, remains a major clinical challenge. immune microenvironment plays an important role the repair defects and favorable environment can effectively promote defects. However, is closely associated with chronic low-grade systemic inflammation, which adversely affects healing. Persistent inflammation critically regulates through all stages. This review explores potential 3D-printed bioceramic scaffolds defect repair, focusing on their capacity to modulate counteract effects aging. not only provide structural support for regeneration but also serve as effective carriers anti-osteoporosis drugs, offering novel therapeutic strategy treating osteoporotic By regulating improving response, may significantly enhance context age-related degeneration. approach underscores advanced biomaterials addressing dual challenges dysregulation, promising avenues development treatments elderly. We hope concepts discussed this could offer strategies suggest future optimization scaffolds.

Language: Английский

MBG/BSA Bone Grafts Immunomodulate Bone Regeneration by Releasing Bioactive Ions in Inflammatory Bone Defects

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 3, 2024

Abstract Since the diseases that cause bone defects are mostly inflammatory diseases, current grafts unable to effectively regulate osteoimmune activity, leading impaired osteogenesis and unfavorable regeneration. In this study, inspired by composition, biomimetic mesoporous bioactive glass nanoparticle (MBG)/bovine serum albumin (BSA) designed for defects. Systematically, MBG/BSA evaluated characterization, bioactivity, anti‐inflammatory, antioxidant osteogenic activity. proved be biocompatible can release ions including calcium silicon in a sustained manner. Furthermore, reprograms macrophage phenotype toward anti‐inflammation is beneficial The antioxidative activity also validated under inflammation mechanism may via interleukin‐4 (IL‐4)/Signal transducer activator of transcription 6 (STAT6) pathway. differentiation mineralization facilitated due improved immunoregulation MBG/BSA. Overall, work suggests with immunomodulatory properties an ideal material regeneration application.

Language: Английский