Pathophysiology of IBD as a Key Strategy for Polymeric Nanoparticle Development

Advanced Therapeutics, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 19, 2025

Abstract Inflammatory bowel disease (IBD) is a complex chronic inflammatory disorder of the gastrointestinal (GI) tract with an uncertain etiology. Currently, IBD therapy relies on induction clinical remission followed by maintenance using anti‐inflammatory drugs and immunosuppressants; however, definite cure still out scope. Established approaches are characterized adverse drug‐related side effects that can even be potentially life‐threatening. In contrast, increased interest remarkable scientific progress in targeted drug delivery systems offer promising approach to reduce systemic events, delivering therapeutic substances only inflamed tissue. All alteration barrier integrity, especially disturbed epithelial barrier, unique pattern receptors cell surface and/or oxidative stress milieu areas used as effective for controlled delivery. Hence, this review focuses pathophysiology GI potential strategy polymeric nanoparticles treatment. Interdisciplinary efforts between chemistry gastroenterology/immunology promise create novel synergies improve development nanoparticle significant impact. regard, current challenges translation nanomedicine also discussed.

Language: Английский

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Unraveling the catalase dynamics: Biophysical and computational insights into co-solutes driven stabilization under extreme pH conditions

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140467 - 140467

Published: Jan. 1, 2025

Language: Английский

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Responsive nanomaterials in biomedicine, patent path and prospect analysis

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 4, 2025

In recent years, responsive nanomaterials have demonstrated tremendous potential in biomedical applications due to their unique advantages precise drug delivery and controlled release. For complex diseases such as cancer, chronic inflammation, genetic disorders, traditional treatment methods are often limited by insufficient targeting significant side effects. Responsive nanotechnology, sensing specific internal or external stimuli, has significantly enhanced the precision efficiency of treatments. This study systematically summarizes technological trajectory emerging research directions through global patent literature data, employing main path analysis, derivative keyword co-occurrence analysis. The results reveal evolution this field, from optimization early single-stimulus-responsive nano systems rise theranostics integration, followed advancements multi-stimuli-responsive synergistic therapies, finally, innovation biomimetic material design. Each developmental phase increasingly focused on adapting biological environments, achieving superior performance, enhancing therapeutic efficacy. Keyword analysis highlights key hotspots, including design, multimodal response mechanisms. future, expected play a pivotal role personalized medicine, multifunctional carrier disease management, providing novel insights support for medicine.

Language: Английский

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Nanotechnology-based drug delivery system for targeted therapy of Ulcerative colitis from traditional chinese medicine: A review

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: 673, P. 125375 - 125375

Published: Feb. 16, 2025

Language: Английский

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Development of Colon-Targeted Naringin-Loaded Microbeads in Acetic Acid-Induced Colitis Model in Rats for the Management of Inflammatory Bowel Disease

Journal of Pharmaceutical Innovation, Journal Year: 2025, Volume and Issue: 20(2)

Published: March 4, 2025

Language: Английский

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Intelligent Nanomaterials Design for Osteoarthritis Managements

Small Methods, Journal Year: 2025, Volume and Issue: unknown

Published: March 30, 2025

Osteoarthritis (OA) is the most prevalent degenerative joint disorder, characterized by progressive degradation, pain, and diminished mobility, all of which collectively impair patients' quality life escalate healthcare expenditures. Current treatment options are often inadequate due to limited efficacy, adverse side effects, temporary symptom relief, underscoring urgent need for more effective therapeutic strategies. Recent advancements in nanomaterials nanomedicines offer promising solutions improving drug bioavailability, reducing effects providing targeted benefits. This review critically examines pathogenesis OA, highlights limitations existing treatments, explores latest innovations intelligent design OA therapy, with an emphasis on their engineered properties, mechanisms, translational potential clinical application. By compiling recent findings, this work aims inspire further exploration innovation nanomedicine, ultimately advancing development personalized therapies.

Language: Английский

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Regulation of signaling pathways by metal and metal-doped nanozymes in inflammatory bowel disease: A therapeutic perspective

Nano Today, Journal Year: 2025, Volume and Issue: 63, P. 102747 - 102747

Published: April 7, 2025

Language: Английский

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Targeted cancer therapy potential of quercetin-conjugated with folic acid-modified nanocrystalline cellulose nanoparticles: a study on AGS and A2780 cell lines

BMC Biotechnology, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 16, 2025

Language: Английский

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Gellan gum-based microbeads for Colon-targeted drug delivery: A promising polysaccharide for controlled and site-specific release

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 143276 - 143276

Published: April 1, 2025

Language: Английский

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Controlled Stimulus-Responsive Delivery Systems for Osteoarthritis Treatment

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(21), P. 11799 - 11799

Published: Nov. 2, 2024

Osteoarthritis (OA), a common and disabling degenerative joint disease, affects millions of people worldwide imposes considerable burden on patients society due to its high prevalence economic costs. The pathogenesis OA is closely related the progressive degradation articular cartilage accompany inflammation; however, itself cannot heal modulate inflammation lack nerves, blood vessels, lymph-vessels. Therefore, reliable effective methods treat remain highly desired. Local administration drugs or bioactive materials by intra-articular injection delivery system represents promising approach OA, especially considering prolonged retention, chondrocytes targeting, stimuli-responsive release achieve precision therapy. This article summarizes discusses advances in currently used systems (nanoparticle, hydrogel, liposome, microsphere) then focuses their applications treatment from perspective endogenous stimulus (redox reactions, pH, enzymes, temperature) exogenous (near-infrared, magnetic, ultrasound)-responsive release. Finally, challenges potential future directions for development nano-delivery are summarized.

Language: Английский

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